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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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121 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] PML, RARA   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 2  Adherens junction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 3  Adipocytokine signaling pathway 
 2 genes, 3 drugs (DrugBank), 24 diseases shown 		  [1] PPARA   D01366   Bezafibrate   [5] 20, 93, 94, 160, 316 
 D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 4  African trypanosomiasis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 5  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 6  Allograft rejection 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 7  Alzheimer disease 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 8  Amoebiasis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 9  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank), 19 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 10  Amyotrophic lateral sclerosis (ALS) 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 11  Antifolate resistance 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TYMS   D01223   Capecitabine   [1] 94 
 12  Antigen processing and presentation 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 13  Apoptosis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 14  Asthma 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 15  Bile secretion 
 2 genes, 2 drugs (DrugBank), 28 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] NR1H4   D00734   Ursodeoxycholic acid   [12] 6, 8, 20, 67, 84, 93, 94, 95, 96, 97, 234, 299 
 16  Bladder cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 17  Breast cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 18  C-type lectin receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 19  Calcium signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 20  cAMP signaling pathway 
 1 gene, 2 drugs (DrugBank), 8 diseases shown 		  [1] PPARA   D01366   Bezafibrate   [5] 20, 93, 94, 160, 316 
 D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 21  Central carbon metabolism in cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 22  Chagas disease (American trypanosomiasis) 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 23  Chemokine signaling pathway 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] CCR2, CCR5   D09878   Cenicriviroc   [1] 94 
 24  Choline metabolism in cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 25  Colorectal cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 26  Cushing syndrome 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 27  Cytokine-cytokine receptor interaction 
 3 genes, 2 drugs (DrugBank), 18 diseases shown 		  [2] CCR2, CCR5   D09878   Cenicriviroc   [1] 94 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 28  Dilated cardiomyopathy (DCM) 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 29  Drug metabolism - other enzymes 
 4 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] HPRT1   D00161   Mercaptopurine   [5] 86, 94, 96, 97, 164 
 D04931 
 [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 [1] RRM1   D01370   Cladribine   [2] 13, 94 
 30  EGFR tyrosine kinase inhibitor resistance 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 31  Endocrine resistance 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 32  Endocytosis 
 3 genes, 3 drugs (DrugBank), 5 diseases shown 		  [1] CCR5   D09878   Cenicriviroc   [1] 94 
 [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [1] PML   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 33  Endometrial cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 34  Epithelial cell signaling in Helicobacter pylori infection 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 35  Epstein-Barr virus infection 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 36  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 37  Estrogen signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [1] RARA   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 38  Fc epsilon RI signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 39  Fluid shear stress and atherosclerosis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 40  Focal adhesion 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 41  FoxO signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 42  Gap junction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 43  Gastric cancer 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [1] RARB   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 44  Glioma 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 45  Glucagon signaling pathway 
 1 gene, 2 drugs (DrugBank), 8 diseases shown 		  [1] PPARA   D01366   Bezafibrate   [5] 20, 93, 94, 160, 316 
 D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 46  Glutathione metabolism 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] RRM1   D01370   Cladribine   [2] 13, 94 
 47  GnRH signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 48  Graft-versus-host disease 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 49  Hematopoietic cell lineage 
 2 genes, 2 drugs (DrugBank), 49 diseases shown 		  [1] MS4A1   D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 50  Hepatitis B 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 51  Hepatitis C 
 3 genes, 4 drugs (DrugBank), 24 diseases shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [1] PPARA   D01366   Bezafibrate   [5] 20, 93, 94, 160, 316 
 D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 52  Hepatocellular carcinoma 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 53  Herpes simplex virus 1 infection 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [1] PML   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 54  HIF-1 signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 55  Human cytomegalovirus infection 
 3 genes, 3 drugs (DrugBank), 18 diseases shown 		  [1] CCR5   D09878   Cenicriviroc   [1] 94 
 [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 56  Human immunodeficiency virus 1 infection 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] CCR5   D09878   Cenicriviroc   [1] 94 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 57  Human papillomavirus infection 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 58  Human T-cell leukemia virus 1 infection 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 59  Hypertrophic cardiomyopathy (HCM) 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 60  IL-17 signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 61  Inflammatory bowel disease (IBD) 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 62  Influenza A 
 2 genes, 2 drugs (DrugBank), 21 diseases shown 		  [1] PML   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 63  Insulin resistance 
 2 genes, 3 drugs (DrugBank), 24 diseases shown 		  [1] PPARA   D01366   Bezafibrate   [5] 20, 93, 94, 160, 316 
 D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 64  JAK-STAT signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 65  Kaposi sarcoma-associated herpesvirus infection 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CCR5   D09878   Cenicriviroc   [1] 94 
 66  Legionellosis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 67  Leishmaniasis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 68  Malaria 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 69  MAPK signaling pathway 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 70  Melanoma 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 71  Metabolic pathways 
 6 genes, 5 drugs (DrugBank), 25 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] HPRT1   D00161   Mercaptopurine   [5] 86, 94, 96, 97, 164 
 D04931 
 [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 [1] RRM1   D01370   Cladribine   [2] 13, 94 
 [1] TYMS   D01223   Capecitabine   [1] 94 
 72  MicroRNAs in cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 73  mTOR signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 74  Natural killer cell mediated cytotoxicity 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 75  Necroptosis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 76  Neuroactive ligand-receptor interaction 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] NR3C1   D00246   Budesonide   [10] 66, 85, 93, 94, 95, 96, 97, 98, 228, 299 
 77  NF-kappa B signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 78  NOD-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 79  Non-alcoholic fatty liver disease (NAFLD) 
 2 genes, 3 drugs (DrugBank), 24 diseases shown 		  [1] PPARA   D01366   Bezafibrate   [5] 20, 93, 94, 160, 316 
 D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 80  Non-small cell lung cancer 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [1] RARB   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 81  One carbon pool by folate 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] TYMS   D01223   Capecitabine   [1] 94 
 82  Osteoclast differentiation 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 83  Oxytocin signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 84  Pancreatic cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 85  Parathyroid hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 86  Pathogenic Escherichia coli infection 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 87  Pathways in cancer 
 4 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [3] PML, RARA, RARB   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 88  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 89  Pertussis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 90  Phospholipase D signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 91  PI3K-Akt signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 92  PPAR signaling pathway 
 1 gene, 2 drugs (DrugBank), 8 diseases shown 		  [1] PPARA   D01366   Bezafibrate   [5] 20, 93, 94, 160, 316 
 D00565   Fenofibrate   [5] 8, 79, 93, 94, 265 
 93  Prostate cancer 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 94  Proteoglycans in cancer 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 95  Purine metabolism 
 4 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] HPRT1   D00161   Mercaptopurine   [5] 86, 94, 96, 97, 164 
 D04931 
 [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 [1] RRM1   D01370   Cladribine   [2] 13, 94 
 96  Pyrimidine metabolism 
 2 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] RRM1   D01370   Cladribine   [2] 13, 94 
 [1] TYMS   D01223   Capecitabine   [1] 94 
 97  Rap1 signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 98  Ras signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 99  Regulation of actin cytoskeleton 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 100  Relaxin signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 101  Rheumatoid arthritis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 102  RIG-I-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 103  Shigellosis 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] EGFR   D04023   Erlotinib   [1] 94 
 D07907 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 104  Small cell lung cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] RARB   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 105  Sphingolipid signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 106  Systemic lupus erythematosus 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 107  T cell receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 108  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 19 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 109  TGF-beta signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 110  Th17 cell differentiation 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] RARA   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 111  TNF signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 112  Toll-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 113  Toxoplasmosis 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] CCR5   D09878   Cenicriviroc   [1] 94 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 114  Transcriptional misregulation in cancer 
 2 genes, 1 drug (DrugBank), 5 diseases shown 		  [2] PML, RARA   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 115  Tuberculosis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 116  Type I diabetes mellitus 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 117  Type II diabetes mellitus 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 118  Ubiquitin mediated proteolysis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PML   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 119  Viral carcinogenesis 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CCR5   D09878   Cenicriviroc   [1] 94 
 120  Viral protein interaction with cytokine and cytokine receptor 
 3 genes, 2 drugs (DrugBank), 18 diseases shown 		  [2] CCR2, CCR5   D09878   Cenicriviroc   [1] 94 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 121  Yersinia infection 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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