@charset "utf-8";


/* section */

section {
    padding: 60px 0;
    padding: 3.75rem 0;
    padding-bottom: 2.5rem;
    overflow: hidden;
}

section .section-title h2 {
    font-family: 'Quicksand', 'Noto Sans JP', sans-serif;
    font-weight: 700;
    color: #000;
    font-size: 42px;
    font-size: 2.625rem;
    font-size: 2.125rem;
    margin-bottom: 46px;
    margin-bottom: 2.875rem;
    margin-bottom: 2.25rem;
    margin-bottom: 2rem;
}


/* main-banner jumbotron */

section#main-banner.jumbotron {
    margin-bottom: 0;
    padding-left: 0;
    padding-right: 0;
    padding: 3rem 0;
    background-image: url(images/main_banner_back.png);
    background-repeat: no-repeat;
    background-size: cover;
    border-radius: 0;
}

section#main-banner h1.main-title {
    font-size: 120px;
    font-size: 7.5rem;
    font-family: 'Quicksand', sans-serif;
    font-weight: 700 !important;
    letter-spacing: -0.15rem;
    color: #000;
    margin-bottom: 0.5rem;
    line-height: 7.5rem;
}

section#main-banner p.main-subtitle {
    font-size: 17px;
    font-size: 1.0625rem;
    font-weight: 500 !important;
    margin-bottom: 3rem;
    /*letter-spacing: -0.15rem;*/
    color: #818181;
}

section#main-banner div .btn {
    border-radius: 23px;
    font-size: 1.1875rem;
    color: #fff;
    font-weight: 500;
    height: 46px;
    line-height: 46px;
    padding: 0;
    transition: all 0.3s ease;
}

section#main-banner div.main-search input {
    border-radius: 23px;
    font-size: 1.1875rem;
    font-weight: 500;
    height: 46px;
    line-height: 46px;
    padding: 0;
    padding-left: 1.375rem;
}

section#main-banner div.main-search input {
    border-top-right-radius: 0;
    border-bottom-right-radius: 0;
}

section#main-banner div.main-search input::placeholder {
    font-family: 'Quicksand', 'Noto Sans JP', sans-serif;
    color: #757575 !important;
    color: #a2a2a2 !important;
    color: transparent;
    font-size: 1.0625rem;
    font-weight: 400 !important;
}

html:lang(ja) section#main-banner div.main-search input::placeholder {
    font-weight: 300 !important;
}

section#main-banner div.main-search input:focus::placeholder {
    color: transparent;
}


section#main-banner div.main-search .btn {
    border-top-left-radius: 0;
    border-bottom-left-radius: 0;
}

section#main-banner div.main-search .input-group {
    max-width: 500px;
}

section#main-banner div.main-search .btn-search {
    width: 80px;
}

section#main-banner div .btn span {
    font-size: 16px;
    font-size: 1rem;
    font-weight: 400;
}

section#main-banner div .btn-disease {
    background-color: #0067b6;
    border-color: #0067b6;
    width: 240px;
    margin: 0 0.5rem;
}

section#main-banner div .btn-disease:hover {
    background-color: #0055a6;
    border-color: #0055a6;
    background-color: #00489c;
    border-color: #00489c;
    transform: translateY(-3px);
    box-shadow: 0px 6px 14px 0px rgb(0 0 0 / 15%);
}

section#main-banner div .btn-drug {
    background-color: #ffa526;
    border-color: #ffa526;
    width: 240px;
    margin: 0 0.5rem;
}

section#main-banner div .btn-drug:hover {
    background-color: #ff931c;
    border-color: #ff931c;
    background-color: #ff8816;
    border-color: #ff8816;
    transform: translateY(-3px);
    box-shadow: 0px 6px 14px 0px rgb(0 0 0 / 15%);
}

section#main-banner div .btn-dna {
    background-color: #19ae9e;
    border-color: #19ae9e;
    width: 368px;
}

section#main-banner div .btn-dna:hover {
    background-color: #129d8c;
    border-color: #129d8c;
    background-color: #0d9280;
    border-color: #0d9280;
    transform: translateY(-3px);
    box-shadow: 0px 6px 14px 0px rgb(0 0 0 / 15%);
}

section#main-banner div .btn:hover {
    /*background-color: #d70a30;
    border-color: #d70a30;*/
    /*transform: translateY(-3px);
    box-shadow: 0px 6px 14px 0px rgb(0 0 0 / 15%);*/
}

section#main-banner div .btn:active {
    /*color: #fff;
    background-color: #ffa526;
    border-color: #ffa526;*/
    /*box-shadow: none;
    border: none;
    outline: none;*/
}

section#main-banner div.main-banner-image img,
section#about div.main-banner-image img {
    transition: all 0.6s ease;
}

section#main-banner div.main-banner-image img:hover,
section#about div.main-banner-image img:hover {
    transform: translateY(-4px);
    /*cursor: pointer;*/
    /*box-shadow: 0px 6px 14px 0px rgb(0 0 0 / 15%);*/
}


/* nav */

nav .nav-back {
    display: none;
}


/* about */

section#about {
    background-color: #fff;
}

section#about p.about-text {
    font-size: 22px;
    font-size: 1.375rem;
    font-weight: 400;
}

section#about p strong {
    font-weight: 600;
}

section#about p.acronym {
    font-size: 1.1875rem;
}


/* news */

section#news {
    background-color: #f7f8f9;
}

div.news-table-frame {
    height: 128px;
    background-color: #fff;
    border: 1px solid #ced4da;
    overflow: auto;
    line-height: 1.6;
    padding-top: 1rem;
    margin-bottom: 1rem;
    margin-top: 0.5rem;
}

table.news-table {
    font-size: 16px;
    font-size: 1rem;
    margin: 0;
}

table.news-table th {
    white-space: nowrap;
    text-align: right;
    padding-right: 1.25rem;
    padding-left: 1.25rem;
}


/* features */

section#features {
    background-color: #fff;
}

.features-title h3 {
    font-size: 23px;
    font-size: 1.4375rem;
    font-weight: 600;
    color: #333;
}

.features-detail {
    font-size: 16px;
    font-size: 1rem;
    font-weight: 400;
    color: #8b8b8b;
}


/* statistics */

section#statistics {
    background-color: #f0f9fe;
}

.statistics-name h3 {
    font-size: 23px;
    font-size: 1.4375rem;
    font-weight: 600;
    color: #333;
    white-space: nowrap;
}

.statistics-number {
    font-size: 48px;
    font-size: 3rem;
    font-size: 2.25rem;
    font-weight: 400;
    font-weight: 500;
}


/* data-source */

section#data-source {
    background-color: #fff;
}

#data-source ul {
    list-style-type: none;
}

#data-source ul li {
    font-size: 16px;
    font-size: 1rem;
    font-weight: 600;
    color: #333;
}

#data-source ul li a {
    font-size: 20px;
    font-size: 1.25rem;
    font-weight: 600;
}

#data-source ul.data-source-list1 li small {
    font-size: 1rem;
    font-weight: 500;
}

#data-source ul.data-source-list2 li small {
    font-size: 1.125rem;
    font-weight: 600;
}


/* disclaimer */

section#disclaimer {
    background-color: #fff8e7;
}


/* icon image */

.features-image,
.statistics-image,
.data-source-image {
    /*margin-bottom: 30px;
    margin-bottom: 30px;*/
    width: 145px;
    height: 145px;
    margin: 0 auto;
    border-radius: 50%;
    border: 10px solid #e2e2e2;
    margin-bottom: 16px;
    transition: all 0.2s ease-in-out;
    background-position: center;
    background-repeat: no-repeat;
    background-size: 145px;
}

.col-anim {
    transition: all 0.2s ease-in-out;
}

.col-anim:hover

/*,
.features-image:hover,
.statistics-image:hover,
.data-source-image:hover*/
    {
    /*transform: translateY(-3px);*/
    /*box-shadow: 0px 6px 14px 0px rgb(0 0 0 / 15%);*/
    /*cursor: pointer;*/
}

.features-image:hover,
.statistics-image:hover,
.data-source-image:hover {
    /*transform: translateY(-3px);
    box-shadow: 0px 6px 14px 0px rgb(0 0 0 / 15%);
    transform: scale(1.05);*/
    /*cursor: pointer;*/
}

.features-image-01 {
    background-image: url(images/icon_features_01.png);
    border-color: #e2e2e2;
}

.features-image-02 {
    background-image: url(images/icon_features_02.png);
    border-color: #e2e2e2;
}

.features-image-03 {
    background-image: url(images/icon_features_03.png);
    border-color: #e2e2e2;

}

.statistics-image-01 {
    background-image: url(images/icon_statistics_01.png);
    border-color: #90bfe1;
}

.statistics-image-02 {
    background-image: url(images/icon_statistics_02.png);
    border-color: #90bfe1;
}

.statistics-image-03 {
    background-image: url(images/icon_statistics_03.png);
    border-color: #f3dca2;
}

.statistics-image-04 {
    background-image: url(images/icon_statistics_04.png);
    border-color: #a4dfdc;
}

.statistics-image-05 {
    background-image: url(images/icon_statistics_05.png);
    border-color: #a4dfdc;
}

.data-source-image-01 {
    background-image: url(images/icon_data-source_01.png);
    border-color: #90bfe1;
}



/* amin */

/*.fadeIn_up {
    opacity: 0;
    transform: translate(0, 25%);
    transition: 1s;
}

.fadeIn_up.is-show {
    transform: translate(0, 0);
    opacity: 1;
}
*/

.fadeIn_up {
    opacity: 0;
    transform: translateY(100px);
    transition: 1s;
}

.fadeIn_up.is-show {
    transform: translateY(0);
    opacity: 1;
}


/*.fadeIn_up {
    animation-name: fadeUpAnime;
    animation-duration: 0.5s;
    animation-fill-mode: forwards;
    opacity: 0;
}

@keyframes fadeUpAnime {
    from {
        opacity: 0;
        transform: translateY(100px);
    }

    to {
        opacity: 1;
        transform: translateY(0);
    }
}*/



/* fix */
section#main-banner .col-6 {
    flex-basis: content;
}

section#main-banner h1.main-title {
    font-size: 120px;
    font-size: 6rem;
    margin-bottom: 0.5rem;
    line-height: 6rem;
}

section#main-banner p.main-subtitle {
    margin-bottom: 3rem;
    margin-bottom: 2.4rem;
}

section#main-banner p.main-subtitle {
    font-size: 1rem;
    letter-spacing: normal;
}

html:lang(en) section#main-banner p.main-subtitle {
    font-size: 0.9rem;
}

section#main-banner div .btn-disease,
section#main-banner div .btn-drug {
    width: 192px;
    width: 200px;
}

section#main-banner div .btn-dna {
    width: 294px;
    width: 320px;
}

section#main-banner div.main-search .input-group {
    max-width: 420px;
}

html:lang(en) section#main-banner div .btn {
    font-size: 1.0rem;

}

section#main-banner div .btn span {
    margin-left: 0.05rem;
    margin-right: 0.05rem;
}

html:lang(en) section#main-banner div .btn span {
    font-size: 0.9rem;
    margin-left: 0.25rem;
    margin-right: 0.25rem;
}


section#main-banner div.main-search input::placeholder {
    font-size: 1.0rem;
}

html:lang(en) section#main-banner div.main-search input::placeholder {
    font-size: 0.9rem;
}

section#main-banner div.main-search.mb-5 {
    margin-bottom: 2.4rem !important;
}

.main-banner-image img {
    height: 384px;
    width: 466px;
}

section#main-banner div.main-banner-image img:hover,
section#about div.main-banner-image img:hover {
    transform: none;
}


/* fix2 image*/
.main-banner-image img {
    display: none;
}

div.main-banner-image {
    position: relative;
    height: 384px;
    width: 466px;
}

div.main-banner-image div.main-banner-image-back {
    position: relative;
    height: 384px;
    width: 466px;
    background-image: url(images/image_ddrare_fig_back.png);
    background-repeat: no-repeat;
    background-size: contain;
}

div.main-banner-image div.main-banner-link a {
    display: block;
    height: 135px;
    width: 135px;
    /*border: 1px solid;*/
    transition: all 0.3s ease;
    background-repeat: no-repeat;
    background-size: contain;
}

div.main-banner-image div.main-banner-link a:hover {
    transform: translateY(-3px);
    transform: scale(1.05);
    /*box-shadow: 0px 6px 14px 0px rgb(0 0 0 / 15%);*/
}

div.main-banner-image div.main-banner-link a.main-banner-disease {
    position: absolute;
    top: 13px;
    left: 165px;
    /*border-color: #6fabd3;*/
    background-image: url(images/image_ddrare_fig_disease.png);
}

div.main-banner-image div.main-banner-link a.main-banner-drug {
    position: absolute;
    top: 206px;
    left: 45px;
    /*border-color: #f5d380;*/
    background-image: url(images/image_ddrare_fig_drug.png);
}

div.main-banner-image div.main-banner-link a.main-banner-dna {
    width: 145px;
    position: absolute;
    top: 206px;
    left: 286px;
    /*border-color: #85d3cc;*/
    background-image: url(images/image_ddrare_fig_dna.png);
}

/* Print */
@media print {
    .fadeIn_up {
        opacity: 1;
        transform: translateY(0);
    }

    section {
        padding-top: 2.5rem;
    }

}

/* footer */

footer div.container {
    max-width: 540px;
}


/* Small devices (landscape phones, 576px and up) */
@media (min-width: 576px) {
    section#main-banner div.main-search input::placeholder {
        color: transparent;
    }

    section {
        padding-top: 3.0rem;
    }

    section#main-banner div.d-xl-block {
        display: none;
    }

    footer div.container {
        max-width: 540px;
    }
}

/* Medium devices (tablets, 768px and up)*/
@media (min-width: 768px) {
    section#main-banner div.main-search input::placeholder {
        color: #8b8b8b;
    }

    section {
        padding-top: 3.0rem;
    }

    section#main-banner div.d-xl-block {
        display: none;
    }

    footer div.container {
        max-width: 720px;
    }
}

/* Large devices (desktops, 992px and up)*/
@media (min-width: 992px) {
    section#main-banner div.main-search input::placeholder {
        color: #8b8b8b;
    }

    section {
        padding-top: 3.0rem;
    }

    section#main-banner div.d-xl-block {
        display: none;
    }

    footer div.container {
        max-width: 960px;
    }

    .navbar-expand-lg {
        height: 56px;
    }
}

/* Extra large devices (large desktops, 1200px and up)*/
@media (min-width: 1200px) {

    .container,
    .container-lg,
    .container-md,
    .container-sm,
    .container-xl {
        max-width: 1200px;
    }

    section {
        padding-top: 3.5rem;
    }

    section#main-banner div.d-xl-block {
        display: block;
    }

    footer div.container {
        max-width: 1200px;
    }
}