Drug Description in Trials / DrugBank / KEGG DRUG /

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1ACETYLSALICYLIC ACID[1] Acetylsalicylic acid[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[4] 13, 46, 51, 210
2ACT-064992----[5] 51, 85, 86, 88, 210
3Administration of an ACE-inhibitor or not----[1] 210
4Aesculus Hippocastanum / Horse Chestnut[1] Horse chestnut[1] D12028 --[1] 210
5Ambrisentan[1] Ambrisentan[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 51, 84, 85, 86, 88, 210, 211
6Arginine[1] Arginine[1] D02982 --[11] 46, 58, 67, 78, 96, 97, 98, 113, 210, 251, 299
7Aspirin[1] Acetylsalicylic acid[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[12] 13, 22, 46, 49, 51, 58, 64, 86, 113, 158, 210, 231
8Autologous cardiac stem cells (JRM-001)----[2] 210, 211
9Autologous Tissue-Engineered Vascular Graft----[1] 210
10BAY 59-7939----[1] 210
11Bosentan[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
12Cardiac progenitor cell infusion----[2] 210, 211
13Carvedilol[1] Carvedilol[1] D00255 [5] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
ADRB2 💬		[13] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 57, 86, 113, 210
14Colchicine[1] Colchicine[1] D00570 [9] TUBB,
TUBB1,
TUBB2A,
TUBB2B,
TUBB3,
TUBB4A,
TUBB4B,
TUBB6,
TUBB8 💬		[10] Alzheimer disease, Amyotrophic lateral sclerosis, Gap junction, Huntington disease, Parkinson disease, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Phagosome, Prion disease, Salmonella infection 💬[7] 2, 42, 46, 56, 93, 210, 266
15Digoxin[1] Digoxin[1] D00298 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬		[18] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 8, 46, 210
16Enalapril[1] Enalapril[1] D07892 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[6] 19, 46, 66, 113, 210, 222
17Eplerenone[1] Eplerenone[1] D01115 [1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[4] 75, 113, 210, 215
18Horse chestnut[1] Horse chestnut[1] D12028 --[1] 210
19IPSC-CL----[1] 210
20JNJ-39039039----[1] 210
21Liothyronine[1] Liothyronine[1] D08128 [2] THRA,
THRB 💬		[2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬[3] 13, 210, 212
22Liothyronine I 131[2] Liothyronine,
Liothyronine I-131		[1] D08128 [2] THRA,
THRB 💬		[2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway 💬[2] 210, 212
23Macitentan[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 51, 85, 86, 88, 210
24MPC----[2] 210, 211
25Mysildecard----[1] 210
26MZ101----[1] 210
27NITRIC OXIDE[1] Nitric Oxide[1] D00074 --[7] 85, 86, 88, 210, 251, 294, 299
28Normal Saline----[18] 6, 13, 17, 22, 36, 46, 49, 60, 70, 94, 96, 210, 211, 226, 271, 276, 296, 299
29ODSH at 0.125 mg/kg/h----[1] 210
30ODSH at 0.250 mg/kg/h----[1] 210
31ODSH at 0.375 mg/kg/h----[1] 210
32Opsumit[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 86, 88, 210
33Opsumit®[1] Macitentan[1] D10135 [2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 86, 88, 210
34Rexlemestrocel-L----[2] 210, 211
35Rivaroxaban[1] Rivaroxaban[1] D07086 [1] F10 💬[1] Complement and coagulation cascades 💬[4] 46, 49, 91, 210
36SCRM001_TEVG----[1] 210
37Sildenafil[1] Sildenafil[1] D08514 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
38Sildenafil by injection[1] Sildenafil[1] D08514 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 210
39Spironolactone[1] Spironolactone[1] D00443 [1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[8] 46, 58, 67, 86, 113, 210, 218, 225
40Spironolactone (drug)[1] Spironolactone[1] D00443 [1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[1] 210
41Sugar pill----[8] 5, 6, 49, 67, 70, 86, 206, 210
42Tadalafil[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[7] 6, 51, 75, 84, 86, 113, 210
43Tadalafil Citrate[1] Tadalafil[1] D02008 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[1] 210
44Tracleer[1] Bosentan[2] D01227 ,
D07538 		[2] EDNRA,
EDNRB 💬		[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[8] 13, 51, 84, 85, 86, 88, 210, 211
45Treprostinil[1] Treprostinil[1] D06213 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 51, 84, 85, 86, 88, 210
46Udenafil[1] Udenafil[1] D10027 [1] PDE5A 💬[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬[2] 86, 210
47Vasopressin[1] Vasopressin[1] D00101 [3] AVPR1A,
AVPR1B,
AVPR2 💬		[5] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬[1] 210
48Vasopressin, Arginine[2] Arginine,
Vasopressin		[2] D00101 ,
D02982 		[3] AVPR1A,
AVPR1B,
AVPR2 💬		[5] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬[1] 210
49Vitamin C[1] Ascorbic acid[1] D00018 --[6] 10, 192, 206, 210, 211, 212
50Xarelto[1] Rivaroxaban[1] D07086 [1] F10 💬[1] Complement and coagulation cascades 💬[2] 49, 210