Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1100 mg ELX (VX-445) / 50 mg TEZ / 75 mg IVA FDC----[1] 299
2100 mg ELX /50 mg TEZ /75 mg IVA FDC----[1] 299
3100 mg ELX/50 mg TEZ /75 mg IVA FDC----[1] 299
4100 mg ELX/50 mg TEZ/75 mg IVA fixed dose combination----[1] 299
5100 mg TEZ/150 mg IVA FDC----[1] 299
6100 mg VX-445 /50 mg TEZ/75 mg IVA FDC----[1] 299
7100 mg VX-445/50 mg TEZ /75 mg IVA FDC----[1] 299
8100-mg ELX (VX-445) / 50-mg TEZ / 75-mg IVA FDC----[1] 299
9100-mg ELX (VX-455) / 50-mg TEZ / 75-mg IVA FDC----[1] 299
10100-mg ELX / 50-mg TEZ / 75 -mg IVA FDC----[1] 299
11100-mg VX-445 / 50-mg TEZ / 75- mg IVA FDC----[1] 299
12100-mg VX-445 / 50-mg TEZ / 75-mg IVA FDC----[1] 299
13100-mg VX-445/50-mg TEZ/75-mg IVA FDC----[1] 299
14100g ELX / 50mg TEZ / 75mg IVA----[1] 299
15100mg ELX/50mg TEZ /75mg IVA----[1] 299
16100mg VX-445/50mg TEZ /75mg IVA FDC----[1] 299
17150-mg IVACAFTOR[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
18150mg IVACAFTOR[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
1950 mg ELX/25 mg TEZ/37.5 mg IVA----[1] 299
2050 mg ELX/25 mg TEZ/37.5 mg IVA fixed dose combination----[1] 299
2175-mg IVACAFTOR[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
2280mg ELX / 40mg TEZ / 60mg IVA----[1] 299
23CF patients with a G551D mutation and treated with Ivacaftor[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
24D-IVA----[1] 299
25Deuterated Ivacaftor[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
26Elexacaftor / Ivacaftor / Tezacaftor[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] D09916 (Name: Ivacaftor),
D11041 ,
D11507 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
27Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] D09916 (Name: Ivacaftor),
D11041 ,
D11507 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
28Elexacaftor-tezacaftor-ivacaftor exposure[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] D09916 (Name: Ivacaftor),
D11041 ,
D11507 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
29Elexacaftor/tezacaftor/ivacaftor[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] D09916 (Name: Ivacaftor),
D11041 ,
D11507 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
30ELX (VX-445)/TEZ (VX-661)/IVA (VX-770)----[1] 299
31ELX/TEZ/IVA----[1] 299
32IVA----[1] 299
33IVA 336----[1] 19
34IVA337----[1] 51
35IVACAFTOR[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
36Ivacaftor (proposed INN)[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
37Ivacaftor 125mg tablet[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
38Ivacaftor 150 mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
39Ivacaftor 150 mg or 250 mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
40Ivacaftor 25 mg/75 mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
41IVACAFTOR 59,5mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
42IVACAFTOR 59.5mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
43Ivacaftor 75 mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
44Ivacaftor 75 mg/150 mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
45IVACAFTOR 75mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
46Ivacaftor Exposed[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
47Ivacaftor or elexacaftor/tezacaftor/ivacaftor[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] D09916 (Name: Ivacaftor),
D11041 ,
D11507 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
48Ivacaftor+lumacaftor[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
49Ivacaftor/Ataluren[2] Ataluren,
Ivacaftor		[2] D09323 ,
D09916 (Name: Ivacaftor)		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
50Ivacaftor/Kalydeco[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
51Ivacaftor/Trikafta[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
52LUM/IVA----[1] 299
53LUM/IVA fixed-dose combination----[1] 299
54Lumacaftor / ivacaftor[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
55Lumacaftor plus Ivacaftor[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
56Lumacaftor Plus Ivacaftor Combination[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
57Lumacaftor, Ivacaftor Drug Combination[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
58Lumacaftor-ivacaftor[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
59Lumacaftor-Ivacaftor treatment[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
60Lumacaftor/Ivacaftor[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
61Lumacaftor/ivacaftor 100mg/125mg tablets[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
62Lumacaftor/ivacaftor 200mg/125mg[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
63Lumacaftor/ivacaftor 200mg/125mg tablets[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
64Lumacaftor/ivacaftor 200mg/83mg tablet[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
65Orkambi: contains lumacaftor and ivacaftor[2] Ivacaftor,
Lumacaftor		[2] D09916 (Name: Ivacaftor),
D10134 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
66TEZ/IVA----[1] 299
67Tezacaftor/Ivacaftor[2] Ivacaftor,
Tezacaftor		[2] D09916 (Name: Ivacaftor),
D11041 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
68Tezacaftor/Ivacaftor + Ivacaftor[2] Ivacaftor,
Tezacaftor		[2] D09916 (Name: Ivacaftor),
D11041 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
69Tezacaftor/Ivacaftor 100mg/150mg[2] Ivacaftor,
Tezacaftor		[2] D09916 (Name: Ivacaftor),
D11041 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
70Tezacaftor/Ivacaftor/100mg/150mg[2] Ivacaftor,
Tezacaftor		[2] D09916 (Name: Ivacaftor),
D11041 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
71Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor[4] Elexacaftor,
Ivacaftor,
Lumacaftor,
Tezacaftor		[4] D09916 (Name: Ivacaftor),
D10134 ,
D11041 ,
D11507 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
72VX-121/TEZ/D-IVA----[1] 299
73VX-445 / TEZ / IVA----[1] 299
74VX-445 / TEZ / IVA FDC----[1] 299
75VX-445 /TEZ/IVA----[1] 299
76VX-445/TEZ/IVA----[1] 299
77VX-659/ TEZ/IVA[1] VX-659---[1] 299
78VX-659/TEZ/IVA[1] VX-659---[1] 299
79VX-659/Tezacaftor/Ivacaftor[3] Ivacaftor,
Tezacaftor,
VX-659		[2] D09916 (Name: Ivacaftor),
D11041 		[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
80VX-661 Plus Ivacaftor Combination[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
81VX-661/Ivacaftor[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
82VX-661/ivacaftor (VX-770) 100mg/150 mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
83VX-661/ivacaftor 100 mg/ 150 mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
84VX-661/ivacaftor 100mg/150 mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
85VX-661/ivacaftor 100mg/150mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
86VX-661/ivacaftor 50 mg/ 75 mg[1] Ivacaftor[1] D09916 (Name: Ivacaftor)[1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
87VX-661/VX-770 (TEZ/IVA)----[1] 299