Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	DHFR	[5] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
2	DHODH	[3] Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	D00749	Leflunomide	[12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
3	DHFR2	[5] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
4	FCER1A	[4] Sphingolipid signaling pathway, Phospholipase D signaling pathway, Fc epsilon RI signaling pathw ...	D05251	Omalizumab	[7] 46, 53, 65, 98, 162, 226, 299
5	FCGRT	-	D11876	Efgartigimod alfa	[1] 162
6	ABL1	[11] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signalin ...	D08066	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
7	NR3C1	[1] Neuroactive ligand-receptor interaction	D00292	Dexamethasone	[7] 162, 222, 235, 257, 283, 296, 299
8	NR3C1	[1] Neuroactive ligand-receptor interaction	D00385	Triamcinolone	[3] 162, 226, 298
9	NR3C1	[1] Neuroactive ligand-receptor interaction	D00407	Methylprednisolone	[11] 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296
10	NR3C1	[1] Neuroactive ligand-receptor interaction	D00472	Prednisolone	[7] 162, 222, 269, 271, 296, 299, 300

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