Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	HDAC5	[3] Neutrophil extracellular trap formation, Viral carcinogenesis, MicroRNAs in cancer	D06320	Vorinostat	[2] 75, 96
2	CDK6	[8] p53 signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Viral carcinogenesis, Mic ...	D10688	Abemaciclib	[1] 34
3	DNMT1	[1] MicroRNAs in cancer	D03665	Decitabine	[3] 13, 60, 63
4	DNMT3A	[1] MicroRNAs in cancer	D03665	Decitabine	[3] 13, 60, 63
5	DNMT3B	[1] MicroRNAs in cancer	D03665	Decitabine	[3] 13, 60, 63
6	EGFR	[16] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D01977	Gefitinib	[1] 75
7	EGFR	[16] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D03455	Cetuximab	[2] 51, 86
8	EGFR	[16] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D07907	Erlotinib	[1] 94
9	EGFR	[16] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D08108	Lapatinib	[3] 34, 74, 75
10	EGFR	[16] Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt sign ...	D08950	Neratinib	[1] 34

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