16. Crow-Fukase syndrome Clinical trials / Disease details


Clinical trials : 13 Drugs : 14 - (DrugBank : 7) / Drug target genes : 4 - Drug target pathways : 75

  
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1ChiCTR2200056637
2022-02-082022-02-09A multicenter, open and exploratory clinical study of pomadomide combined with dexamethasone in the treatment of newly diagnosed POEMS syndromeA multicenter, open and exploratory clinical study of pomadomide combined with dexamethasone in the treatment of newly diagnosed POEMS syndrome Multiple myelomaPd:Pomadomide combined with dexamethasone in the treatment of patients with newly diagnosed POEMS syndrome ;Qingdao Municipal HospitalNULLRecruiting18100BothPd:30;Phase 4China
2NCT05263817
(ClinicalTrials.gov)
October 8, 20211/12/2021A Clinical Study of CD19/BCMA CAR-T Cells in the Treatment of Refractory POEMS Syndrome, Amyloidosis, Autoimmune Hemolytic Anemia, and VasculitisA Clinical Study on the Safety and Effectiveness of CD19/BCMA Chimeric Antigen Receptor T Cells in the Treatment of Refractory POEMS Syndrome, Amyloidosis, Autoimmune Hemolytic Anemia, and VasculitisPOEMS Syndrome;Amyloidosis;Autoimmune Hemolytic Anemia;VasculitisBiological: CD19/BCMA CAR T-cellsZhejiang UniversityYake Biotechnology Ltd.RecruitingN/AN/AAll75Early Phase 1China
3NCT02921893
(ClinicalTrials.gov)
October 31, 201626/9/2016Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS SyndromeIxazomib, Lenalidomide, and Dexamethasone for Patients With POEMS SyndromePlasmacytoma;POEMS SyndromeDrug: Dexamethasone;Drug: Ixazomib Citrate;Drug: Lenalidomide;Other: Questionnaire AdministrationMayo ClinicNational Cancer Institute (NCI)Active, not recruiting18 YearsN/AAll21Early Phase 1United States
4JPRN-jRCTs031180421
15/08/201625/03/2019LDCY-POEMS studyPhase II study of efficiency of peripheral blood stem cell harvest using low-dose cyclophosphamide plus G-CSF for POEMS syndrome POEMS syndrome
POEMS syndrome
Treatment by cyclophosphamide, mesna, graniserton, and lenograstim. Autologous peripheral blood stem cell harvest (auto-PBSCH)Sakaida EmikoNULLRecruiting>= 20age old<= 70age oldBoth14Phase 2Japan
5JPRN-UMIN000018660
2015/08/1717/08/2015Japanese POEMS syndrome with thalidmaide trial for compassionate useJapanese POEMS syndrome with thalidmaide trial for compassionate use - Japanese POEMS syndrome with thalidmaide trial for compassionate use (JPOST15) Crow-Fukase(POEMS) syndromeFPF300 (thalidomide)100-300mg/day,at bedtime +Dexamethasone 20mg/day (day1-4)

Duration:until the approval of thalidomide for POEMT syndrome
Chiba University Graduate School of MedicineNULLComplete: follow-up complete20years-oldNot applicableMale and Female20Not selectedJapan
6JPRN-UMIN000018385
2015/07/0122/07/2015Phase II study of efficiency of peripheral blood stem cell harvest in POEMS syndrome patients with low-dose cyclophosphamide plus G-CSFPhase II study of efficiency of peripheral blood stem cell harvest in POEMS syndrome patients with low-dose cyclophosphamide plus G-CSF - Phase II study of efficiency of peripheral blood stem cell harvest in POEMS syndrome patients with low-dose cyclophosphamide plus G-CSF POEMS syndromeThis study is composed of the following two steps of therapy.
1)PBSC mobilization using low dose cyclophosphamide and G-CSF
2)autologous peripheral stem cell transplantation after high dose chemotherapy
Chiba University HospitalDepartment of HematologyNULLPending20years-old70years-oldMale and Female14Phase 2Japan
7NCT02193698
(ClinicalTrials.gov)
July 201416/7/2014Efficacy and Safety of Lenalidomide as a Treatment for Recurrent or Refractory POEMS Syndrome TrialSingle Arm Open-label Trial to Investigate the Efficacy and Safety of Lenlidomide as a Treatment for Recurrent or Refractory Crow-Fukase (POEMS) SyndromePOEMS SyndromeDrug: Lenalidomide+DexamethasoneChiba UniversityNULLCompleted20 YearsN/ABoth5Phase 2Japan
8NCT01816620
(ClinicalTrials.gov)
March 201414/3/2013Study to Evaluate Lenalidomide Plus Dexamethasone in Patients With Newly Diagnosed POEMS SyndromeAn Open-label Phase II Study to Determine the Efficacy and Safety of Lenalidomide Plus Dexamethasone (LDex) in Patients With Newly Diagnosed POEMS SyndromePOEMS SyndromeDrug: Lenalidomide, DexamethasonePeking Union Medical College HospitalCelgene CorporationCompleted18 YearsN/AAll41Phase 2China
9NCT01639898
(ClinicalTrials.gov)
July 20125/7/2012POEMS Syndrome Treatment With LenalidomidePhase II Trial With Lenalidomide-Dexamethasone Combination in the Treatment of POEMS Syndrome.POEMS SyndromeDrug: Lenalidomide and dexamethasoneUniversity Hospital, LimogesMinistry of Health, France;Celgene CorporationCompleted18 YearsN/AAll51Phase 2France
10JPRN-JMA-IIA00084
22/03/201219/03/2012Japanese POEMS Syndrome with Thalidomide TrialJapanese POEMS Syndrome with Thalidomide Trial Crow-Fukase (POEMS) syndromeIntervention type:DRUG. Intervention1:FPF 300 (thalidomide), Dose form:CAPSULE, Route of administration:ORAL.J-POST Clinical Trial OfficeHokkaido University, Hokkaido Medical Center, Tohoku University, Chiba University, Saitama Medical University, Niigata University, Shinshu University, Nagoya University, Kinki University, Kobe City Medical Center General Hospital, Yamaguchi University, Kyushu University, Kagoshima UniversityCompleted>=20 YEARSNo LimitBOTH24Phase 3Japan
11JPRN-JMA-IIA00046
13/09/201006/09/2010Japanese POEMS Syndrome with Thalidomide TrialThalidomide Treatment for Crow-Fukase (POEMS) Syndrome: A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial with an Extension Phase to Evaluate the Long-term Safety Crow-Fukase (POEMS)syndromeIntervention type:DRUG. Intervention1:FPF 300 (thalidomide), Dose form:CAPSULE, Route of administration:ORAL. Control intervention1:FPF300 (placebo), Dose form:CAPSULE, Route of administration:ORAL.J-POST Clinical Trial OfficeHokkaido University, Hokkaido Medical Center, Tohoku University, Chiba University, Saitama Medical University, Niigata University, Shinshu University, Nagoya University, Kinki University, Kobe City Medical Center General Hospital, Yamaguchi University, Kyushu University, Kagoshima UniversityCompleted>=20 YEARSNo LimitBOTH24Phase 2-3Japan
12EUCTR2008-003202-33-IT
(EUCTR)
15/09/200917/11/2009Evaluation of efficacy and safety of Lenalidomide (Revlimid) in patients with POEMS Syndrome - ONC-2008-002Evaluation of efficacy and safety of Lenalidomide (Revlimid) in patients with POEMS Syndrome - ONC-2008-002 POEMS SYNDROME
MedDRA version: 9.1;Level: SOC;Classification code 10029205
Trade Name: REVLIMID*21CPS 25MG
INN or Proposed INN: Lenalidomide
ISTITUTO CLINICO HUMANITASNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Italy
13NCT00971685
(ClinicalTrials.gov)
July 20093/9/2009The Treatment of Lenalidomide in Patients With POEMS SyndromeEvaluation of Efficacy and Safety of Lenalidomide (Revlimid®) in Patients With POEMS SyndromePOEMS SyndromeDrug: Lenalidomide and dexamethasoneIstituto Clinico HumanitasNULLRecruiting18 YearsN/ABoth16Phase 2Italy