167. Marfan syndrome Clinical trials / Disease details

Clinical trials : 21 / Drugs : 40 - (DrugBank : 11) / Drug target genes : 10 - Drug target pathways : 50

12 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00782327 (ClinicalTrials.gov)	November 1, 2009	29/10/2008	Randomized, Double-blind Study for the Evaluation of the Effect of LosartanVersus Placebo on Aortic ...	Randomized, Double-blind Study for the Evaluation of the Effect of LosartanVersus Placebo on Aortic ...	Marfan Syndrome	Drug: Losartan;Drug: Placebo	University Hospital, Ghent	Agentschap voor Innovatie door Wetenschap en Technologie	Completed	10 Years	N/A	All	22	Phase 3	Belgium
2	EUCTR2007-005862-10-BE (EUCTR)	29/05/2009	07/01/2009	Randomized, double-blind study for the evaluation of the effect of losartanversus placebo on aortic ...	Randomized, double-blind study for the evaluation of the effect of losartanversus placebo on aortic ...	Marfan syndrome MedDRA version: 9.1;Level: LLT;Classification code 10026829;Term: Marfan's syndrome	Trade Name: Cozaar Product Name: Losartan INN or Proposed INN: Losartan potassium Trade Name: Coozar Prod ...	University Hospital Ghent	NULL	Not Recruiting			Female: yes Male: yes			Belgium
3	EUCTR2008-001462-81-IT (EUCTR)	27/10/2008	17/03/2008	Effects of Losartanversus Nebivolol versus the association of both on the progression of aortic root ...	Effects of Losartanversus Nebivolol versus the association of both on the progression of aortic root ...	Marfan Syndrome MedDRA version: 9.1;Level: LLT;Classification code 10026829;Term: Marfan's syndrome	Trade Name: LORTAAN 28CPR RIV DIV 50MG INN or Proposed INN: Losartan Trade Name: LOBIVON 28CPR 5MG INN ...	OSPEDALE POLICLINICO S. MATTEO	NULL	Not Recruiting			Female: yes Male: yes		Phase 3	Italy
4	NCT01145612 (ClinicalTrials.gov)	October 2008	15/6/2010	Atenolol Versus Losartan in the Prevention of Progressive Dilation of the Aorta in Marfan Syndrome	A Clinical Trial to Assess the Efficacy and Safety of LosartanVersus Atenolol in the Prevention of P ...	Marfan Syndrome	Drug: Losartan;Drug: Atenolol	Forteza, Albert, M.D.	Ministry of Health, Spain	Active, not recruiting	5 Years	60 Years	Both	140	Phase 3	Spain
5	NCT00763893 (ClinicalTrials.gov)	September 2008	30/9/2008	Study of the Efficacy of Losartan on Aortic Dilatation in Patients With Marfan Syndrome	Multicenter, Randomised, Double Blind Study of the Efficacy of Losartanon Aortic Dilatation in Patie ...	Marfan Syndrome	Drug: placebo;Drug: Losartan	Assistance Publique - Hôpitaux de Paris	NULL	Terminated	10 Years	N/A	Both	303	Phase 3	France
6	NCT00683124 (ClinicalTrials.gov)	July 2008	21/5/2008	Nebivolol Versus LosartanVersus Nebivolol+LosartanAgainst Aortic Root Dilation in Genotyped Marfan P ...	Effects of Losartanvs. Nebivolol vs. the Association of Both on the Progression of Aortic Root Dilat ...	Marfan Syndrome	Drug: Losartan and nebivolol;Drug: Losartan;Drug: Nebivolol	IRCCS Policlinico S. Matteo	Merck Sharp & Dohme Corp.;Menarini Group	Recruiting	12 Months	55 Years	Both	291	Phase 3	Italy
7	EUCTR2007-001125-97-ES (EUCTR)	20/05/2008	03/12/2007	Eficacia y Seguridad de Losartán vs Atenolol en la prevención de la dilatación progresiva de la aort ...	Eficacia y Seguridad de Losartán vs Atenolol en la prevención de la dilatación progresiva de la aort ...	The aortic dilatation in Marfan syndrome with two different treatments: losartanvs atenolol MedDRA v ...	Trade Name: cozaar 50 INN or Proposed INN: LOSARTAN POTASSIUM Trade Name: blokium 50 INN or Proposed INN ...	alberto forteza	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Spain
8	NCT00593710 (ClinicalTrials.gov)	January 2008	3/1/2008	Losartan Versus Atenolol for the Treatment of Marfan Syndrome	A Randomized Double-blind Study Assessing the Effects of LosartanVersus Atenolol on Pulse Wave Veloc ...	Marfan Syndrome	Drug: Losartan;Drug: Atenolol	University of British Columbia	Heart and Stroke Foundation of Canada	Completed	12 Years	25 Years	Both	17	Phase 2	Canada
9	NCT00723801 (ClinicalTrials.gov)	October 2007	25/7/2008	Effects of LosartanVersus Atenolol on Aortic and Cardiac Muscle Stiffness in Adults With Marfan Synd ...	Effects of Losartanvs Atenolol on Aortic Stiffness and Diastolic Function in Adults With Marfan Synd ...	Marfan Syndrome	Drug: Atenolol;Drug: Losartan	Brigham and Women's Hospital	Boston Children’s Hospital	Completed	25 Years	N/A	All	40	Phase 3	United States
10	NCT00651235 (ClinicalTrials.gov)	February 2007	3/3/2008	A Randomized, Open-label, LOSARTANTherapy on the Progression of Aortic Root Dilation in Patients Wit ...	A Randomized, Open-label, Active Control Trial to Evaluate the Effect of LOSARTANTherapy on the Prog ...	Marfan Syndrome	Drug: Losartan and Atenolol or Propranolol;Drug: Atenolol or Propranolol	National Taiwan University Hospital	NULL	Recruiting	1 Year	N/A	Both	44	Phase 2	Taiwan

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