215. Tetralogy of Fallot Clinical trials / Disease details

Clinical trials : 18 / Drugs : 26 - (DrugBank : 14) / Drug target genes : 13 - Drug target pathways : 45

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05579964 (ClinicalTrials.gov)	October 10, 2022	11/10/2022	The Role of Dexmedetomidine as Myocardial Protector in Pediatric Cardiac Surgery Total Correction of ...	The Role of Dexmedetomidine as Myocardial Protector in Pediatric Cardiac Surgery Total Correction of ...	Congenital Heart Disease in Children;Cardiopulmonary Bypass;Tetralogy of Fallot	Drug: Dexmedetomidine Hcl 100 Mcg/mL Inj;Drug: Placebo	National Cardiovascular Center Harapan Kita Hospital Indonesia	NULL	Recruiting	1 Month	18 Years	All	66	Phase 2/Phase 3	Indonesia
2	NCT05186415 (ClinicalTrials.gov)	August 23, 2022	20/12/2021	Contrast Enhanced Three Dimensional Echocardiographic Quantification of Right Ventricular Volumes in ...	Contrast Enhanced Three Dimensional Echocardiographic Quantification of Right Ventricular Volumes in ...	Tetralogy of Fallot;Pulmonary Insufficiency	Drug: Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON]	Nemours Children's Health System	Thomas Jefferson University	Recruiting	11 Years	N/A	All	60	Phase 1/Phase 2	United States
3	NCT05176782 (ClinicalTrials.gov)	December 15, 2021	15/12/2021	Comparison Between Histidine-tryptophan-ketoglutarate Cardioplegia and Cold Blood Cardioplegia for M ...	Randomized Clinical Trial: Comparison Between Histidine-tryptophan-ketoglutarate Cardioplegia and Co ...	Anesthesia	Drug: HTK cardioplegia;Drug: Cold Cadioplegia	Ain Shams University	NULL	Recruiting	6 Months	5 Years	All	52	Early Phase 1	Egypt
4	ChiCTR2000033234	2020-06-05	2020-05-25	Comprehensive study for surgical effect and prognosis of Tetralogy of Fallot	A single-center ambispective cohort study for surgical effect and prognostic factors of Tetralogy of ...	Tetralogy of Fallot	TOF AS:annlus-sparing repair;TOF TAPE:transannular patch enlargement;	Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and ...	NULL	Pending			Both	TOF AS:247;TOF TAPE:247;	N/A	China
5	NCT04017975 (ClinicalTrials.gov)	December 20, 2019	10/7/2019	Optical Tissue Identification for Myocardial Architecture	Optical Tissue Identification for Myocardial Architecture (OPTIMA Study)	Ventricular Septal Defect;Complete Atrioventricular Canal;Tetralogy of FallotWith Pulmonary Stenosis ...	Drug: Fluorescite;Device: Cellvizio 100 Series System with Confocal Miniprobes	Aditya Kaza	National Heart, Lung, and Blood Institute (NHLBI)	Active, not recruiting	30 Days	18 Years	All	70	Phase 2	United States
6	ChiCTR1900025513	2019-09-01	2019-08-31	The safety and efficacy of preoperative oral supplementation of coenzyme Q10 in improving postoperat ...	The safety and efficacy of preoperative oral supplementation of coenzyme Q10 in improving postoperat ...	tetralogy of fallot (pulmonary atresia)	01:N/A ;02:Oral coenzyme Q10, 2.5mg, t.i.d.;03:Oral coenzyme Q10, 5mg, t.i.d.;04:Oral coenzyme Q10, ...	Fuwai Central China Cardiovascualr Hospital	NULL	Pending	0	2	Both	01:8;02:8;03:8;04:8;05:8;		China
7	ChiCTR1800019578	2018-12-01	2018-11-18	Effects of different tranexamic acid regimen in cyanotic pediatric cardiac surgery	Effects of different tranexamic acid regimen in cyanotic pediatric cardiac surgery	Tetralogy of Fallot	Conventional treatment group:Childen did not receive an antifibrinolytic agent during surgery;Low do ...	National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and ...	NULL	Pending			Both	Conventional treatment group:225;Low dose of tranexamic acid group:225;High dose of tranexamic acid group:225;		China
8	ChiCTR-IOR-16008571	2016-06-06	2016-05-31	Premedication for children with Tetralogy of Fallot	A comparative evalution of varies premedication regimes on children with Tetralogy of Fallot	Tetralogy of Fallot	oral dexmedetomidine:oral dexmedetomidine;oral ketamine:oral ketamine;oral dexmedetomidinemixed with ...	Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University	NULL	Recruiting			Both	oral dexmedetomidine:20;oral ketamine:20;oral dexmedetomidine mixed with ketamine:20;		China
9	EUCTR2013-002091-41-NL (EUCTR)	09/10/2014	05/11/2013	Research into the effect of the drug losartan in adult patients with a reduced function of the right ...	Right vEntricular Dysfunction in tEtralogy of Fallot: INhibition of the rEnin-angiotensin-aldosteron ...	To study the effect of losartan in adult patients with Tetralogy of Fallotand right ventricular dysf ...	Trade Name: Losartan Product Name: Losartan INN or Proposed INN: Losartan Potassium Other descriptive na ...	Academisch medisch centrum	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Netherlands
10	NCT01915277 (ClinicalTrials.gov)	April 2, 2014	30/7/2013	A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety a ...	A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety a ...	Transposition of the Great Arteries;Tetralogy of Fallot;Ventricular Septal Defect	Drug: Dexmedetomidine	HealthCore-NERI	National Heart, Lung, and Blood Institute (NHLBI)	Completed	N/A	180 Days	All	119	Phase 1	United States

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