215. Tetralogy of Fallot Clinical trials / Disease details


Clinical trials : 18 Drugs : 26 - (DrugBank : 14) / Drug target genes : 13 - Drug target pathways : 45

  
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT05579964
(ClinicalTrials.gov)
October 10, 202211/10/2022The Role of Dexmedetomidine as Myocardial Protector in Pediatric Cardiac Surgery Total Correction of Tetralogy of FallotThe Role of Dexmedetomidine as Myocardial Protector in Pediatric Cardiac Surgery Total Correction of Tetralogy of FallotCongenital Heart Disease in Children;Cardiopulmonary Bypass;Tetralogy of FallotDrug: Dexmedetomidine Hcl 100 Mcg/mL Inj;Drug: PlaceboNational Cardiovascular Center Harapan Kita Hospital IndonesiaNULLRecruiting1 Month18 YearsAll66Phase 2/Phase 3Indonesia
2NCT05186415
(ClinicalTrials.gov)
August 23, 202220/12/2021Contrast Enhanced Three Dimensional Echocardiographic Quantification of Right Ventricular Volumes in Repaired Congenital Heart DiseaseContrast Enhanced Three Dimensional Echocardiographic Quantification of Right Ventricular Volumes in Repaired Congenital Heart DiseaseTetralogy of Fallot;Pulmonary InsufficiencyDrug: Sulfur Hexafluoride Lipid Type A Microspheres 25 MG Injection Powder for Suspension [LUMASON]Nemours Children's Health SystemThomas Jefferson UniversityRecruiting11 YearsN/AAll60Phase 1/Phase 2United States
3NCT05176782
(ClinicalTrials.gov)
December 15, 202115/12/2021Comparison Between Histidine-tryptophan-ketoglutarate Cardioplegia and Cold Blood Cardioplegia for Myocardial Protection for Fallot Tetralogy Patients Undergoing Total RepairRandomized Clinical Trial: Comparison Between Histidine-tryptophan-ketoglutarate Cardioplegia and Cold Blood Cardioplegia for Myocardial Protection for Fallot Tetralogy Patients Undergoing Total RepairAnesthesiaDrug: HTK cardioplegia;Drug: Cold CadioplegiaAin Shams UniversityNULLRecruiting6 Months5 YearsAll52Early Phase 1Egypt
4ChiCTR2000033234
2020-06-052020-05-25Comprehensive study for surgical effect and prognosis of Tetralogy of FallotA single-center ambispective cohort study for surgical effect and prognostic factors of Tetralogy of Fallot after surgical repair Tetralogy of FallotTOF AS:annlus-sparing repair;TOF TAPE:transannular patch enlargement;Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeNULLPendingBothTOF AS:247;TOF TAPE:247;N/AChina
5NCT04017975
(ClinicalTrials.gov)
December 20, 201910/7/2019Optical Tissue Identification for Myocardial ArchitectureOptical Tissue Identification for Myocardial Architecture (OPTIMA Study)Ventricular Septal Defect;Complete Atrioventricular Canal;Tetralogy of Fallot With Pulmonary StenosisDrug: Fluorescite;Device: Cellvizio 100 Series System with Confocal MiniprobesAditya KazaNational Heart, Lung, and Blood Institute (NHLBI)Active, not recruiting30 Days18 YearsAll70Phase 2United States
6ChiCTR1900025513
2019-09-012019-08-31The safety and efficacy of preoperative oral supplementation of coenzyme Q10 in improving postoperative cardiac function in children with tetralogy of fallot (pulmonary atresia): a preliminary studyThe safety and efficacy of preoperative oral supplementation of coenzyme Q10 in improving postoperative cardiac function in children with tetralogy of fallot (pulmonary atresia): a preliminary study tetralogy of fallot (pulmonary atresia)01:N/A ;02:Oral coenzyme Q10, 2.5mg, t.i.d.;03:Oral coenzyme Q10, 5mg, t.i.d.;04:Oral coenzyme Q10, 10mg, t.i.d.;05:Oral coenzyme Q10, 20mg, t.i.d.;Fuwai Central China Cardiovascualr HospitalNULLPending02Both01:8;02:8;03:8;04:8;05:8;China
7ChiCTR1800019578
2018-12-012018-11-18Effects of different tranexamic acid regimen in cyanotic pediatric cardiac surgeryEffects of different tranexamic acid regimen in cyanotic pediatric cardiac surgery Tetralogy of FallotConventional treatment group:Childen did not receive an antifibrinolytic agent during surgery;Low dose of tranexamic acid group:Loading dose: 10mg/kg (infant), 5mg/kg (children); Infusion: 2mg/kg.h; CPB prime dose: 20ug/mL of prime volume;High dose of tranexamic acid group:Loading dose: 30mg/kg (infant), 15mg/kg (children); Infusion: 6mg/kg.h; CPB prime dose: 60ug/mL of prime volume;National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeNULLPendingBothConventional treatment group:225;Low dose of tranexamic acid group:225;High dose of tranexamic acid group:225;China
8ChiCTR-IOR-16008571
2016-06-062016-05-31Premedication for children with Tetralogy of FallotA comparative evalution of varies premedication regimes on children with Tetralogy of Fallot Tetralogy of Fallotoral dexmedetomidine:oral dexmedetomidine;oral ketamine:oral ketamine;oral dexmedetomidine mixed with ketamine:oral dexmedetomidine mixed with ketamine;Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong UniversityNULLRecruitingBothoral dexmedetomidine:20;oral ketamine:20;oral dexmedetomidine mixed with ketamine:20;China
9EUCTR2013-002091-41-NL
(EUCTR)
09/10/201405/11/2013Research into the effect of the drug losartan in adult patients with a reduced function of the right cardiac chamber and a cardiac birth defectRight vEntricular Dysfunction in tEtralogy of Fallot: INhibition of the rEnin-angiotensin-aldosterone system - Redefine trial To study the effect of losartan in adult patients with Tetralogy of Fallot and right ventricular dysfunction, defined as right ventricular ejection fraction <50%. Without severe valvular lesions.;Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14]Trade Name: Losartan
Product Name: Losartan
INN or Proposed INN: Losartan Potassium
Other descriptive name: LOSARTAN POTASSIUM
Academisch medisch centrumNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Netherlands
10NCT01915277
(ClinicalTrials.gov)
April 2, 201430/7/2013A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsA Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsTransposition of the Great Arteries;Tetralogy of Fallot;Ventricular Septal DefectDrug: DexmedetomidineHealthCore-NERINational Heart, Lung, and Blood Institute (NHLBI)CompletedN/A180 DaysAll119Phase 1United States
11NCT02010905
(ClinicalTrials.gov)
December 20136/12/2013Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone SystemRight Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone SystemTetralogy of Fallot;Heart Defects, Congenital;Ventricular Dysfunction, RightDrug: Losartan;Drug: PlaceboAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)The Interuniversity Cardiology Institute of the NetherlandsRecruiting18 Years80 YearsBoth120Phase 2Netherlands
12NCT01941576
(ClinicalTrials.gov)
September 1, 20133/9/2013Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of FallotEffects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of FallotCongenital Heart Defects;Tetralogy Of FallotDrug: recombinant human brain natriuretic peptide (rhBNP);Drug: Placebo (0.9% sodium chloride)Shanghai Jiao Tong University School of MedicineNULLCompleted1 Month18 YearsAll120N/AChina
13NCT01971593
(ClinicalTrials.gov)
August 201323/10/2013The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart DiseaseEplerenone to Prevent Myocardial Fibrosis in Congenital Heart DiseaseTetralogy of Fallot;Transposition of the Great Vessels With an Arterial Switch;Single Ventricle With a Fontan PalliationDrug: EplerenoneWashington University School of MedicinePfizerTerminated18 Years80 YearsAll26Phase 4United States
14NCT00848393
(ClinicalTrials.gov)
November 200819/2/2009Measures to Lower the Stress Response in Pediatric Cardiac SurgeryStress Response in Children Undergoing Cardiac Surgery: a Prospective Randomized Comparison Between Low Dose Fentanyl (LDF), Low Dose Fentanyl Plus Dexmedetomidine (LDF + Dex) and High Dose Fentanyl (HDF).Tetralogy of Fallot (TOF);Ventricular Septal Defects (VSD);Atrioventricular Septal Defects (AVSD)Drug: Fentanyl (High Dose);Drug: Fentanyl (Low Dose);Drug: Fentanyl (Low Dose) + DexmedetomidineNationwide Children's HospitalNULLCompleted1 Month3 YearsAll52Phase 2United States
15EUCTR2007-003461-41-DE
(EUCTR)
13/11/200710/09/2007Cardiac imaging under dobutamine stress for early assessment of right ventricular function in patients with tetralogy of Fallot and pulmonary regurgitation - Fallot-stressCardiac imaging under dobutamine stress for early assessment of right ventricular function in patients with tetralogy of Fallot and pulmonary regurgitation - Fallot-stress Fallot tetralogy late after repair with marked pulmonary valve incompetenceINN or Proposed INN: DobutamineDeutsche Herzzentrum Berlin, Kompetenznetz Angeborene HerzfehlerNULLNot RecruitingFemale: yes
Male: yes
80Germany
16NCT00564993
(ClinicalTrials.gov)
November 200728/11/2007Cardiac Function Under Stress for Early Detection of the Right Ventricular Insufficiency After Repair of Tetralogy of FallotCardiac Imaging Under Exercise Stress Test for Early Assessment of Right Ventricular Function in Patients With Tetralogy of Fallot and Pulmonary RegurgitationTetralogy of FallotDrug: DobutaminCompetence Network for Congenital Heart DefectsGerman Federal Ministry of Education and ResearchTerminated14 YearsN/ABoth53Phase 3Germany
17NCT00573066
(ClinicalTrials.gov)
May 200411/12/2007Understanding Dexmedetomidine In Infants Post-Operative From Cardiac SurgeryThe Pharmacokinetics, Pharmacogenetics, and Pharmacodynamics of Dexmedetomidine In Infants Post-Operative From Cardiac SurgeryHypoplastic Left Heart;Tetralogy of Fallot;Tricuspid AtresiaDrug: DexmedetomidineAthena ZuppaNULLCompleted1 Month24 MonthsAll56Phase 1NULL
18NCT00004361
(ClinicalTrials.gov)
July 199518/10/1999Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac DefectsHypoparathyroidism;Tetralogy of Fallot;Pulmonary Valve Stenosis;Conotruncal Cardiac Defects;Heart Defects, Congenital;Pulmonary AtresiaDrug: calcium gluconate;Drug: sodium citrateNational Center for Research Resources (NCRR)Ann & Robert H Lurie Children's Hospital of ChicagoCompleted18 YearsN/ABoth150N/ANULL