22. Moyamoya disease Clinical trials / Disease details


Clinical trials : 17 Drugs : 22 - (DrugBank : 17) / Drug target genes : 33 - Drug target pathways : 45

  
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1JPRN-jRCTs071220048
29/08/202229/08/2022Angiogenesis augmentation therapy for indirect revascularization of moyamoya disease using G-CSFAngiogenesis augmentation therapy for indirect revascularization of moyamoya disease using G-CSF - EDFAPS-G Moyamoya disease
Moyamoya disease, indirect revascularization, Granulocyte-Colony Stimulating Factor;D009072
G-CSF(75 micrograms/body) is applied intraoperatively to the indirect revascularization site, and G-CSF (75 micrograms/body) is given intravenously once daily for 2 days.Morioka MotohiroNULLRecruiting>= 20age old<= 60age oldBoth5Phase 1-2Japan
2ChiCTR2100050185
2021-08-232021-08-21Effect of stellate ganglion block on intracranial vascular and prognosis in patients with Moyamoya diseaseEffect of stellate ganglion block on intracranial vascular and prognosis in patients with Moyamoya disease Moyamoya diseaseSGB group:Ipsilateral stellate ganglion block was performed with 0.2% ropivacaine 8ml;control group:Routine extracranial artery bypass grafting only;The First Affiliated Hospital of Sun Yat-sen UniversityNULLPending1265BothSGB group:12;control group:12;Phase 1China
3ChiCTR2100050015
2021-08-122021-08-15Effect of stellate ganglion block on intracranial vascular and stress level in patients with Moyamoya diseaseEffect of stellate ganglion block on intracranial vascular and stress level in patients with Moyamoya disease Moyamoya diseasestellate ganglion group:1.5% lidocaine planetary ganglion block; control group:DSA only, no stellate ganglion block;the First Affiliated Hospital of Sun Yat-Sen UniversityNULLPending1265Bothstellate ganglion group:12; control group:12;China
4ChiCTR2100046178
2021-05-102021-05-08Efficacy and safety of antiplatelet drugs in patients with moyamoya disease after revascularization Efficacy and safety of antiplatelet drugs in patients with moyamoya disease after revascularization Moyamoya diseaseTaking aspirin group:Nil;No aspirin group:Nil;Qilu Hospital of Shandong UniversityNULLRecruiting060BothTaking aspirin group:105;No aspirin group:105;china
5JPRN-jRCTs031200402
23/04/202108/03/2021Search for abnormalities of fundus blood vessels in moyamoya diseaseSearch for abnormalities of fundus blood vessels in moyamoya disease Moyamoya disease
Moyamoya disease
For fluorescein fundus angiography, 500 mg of fluorescein (5 ml vial of aqueous solution containing 500 mg of fluorescein) and 25 mg of Ophthagreen (2 ml of blue indocyanine green) are dissolved in 2 ml of distilled water for injection and injected through the forearm of the elbow vein. In daily practice, diabetic retinopathy can be treated by using a diabetic retinal imaging system (optos). In daily practice, it is used for the diagnosis of diabetic retinopathy, uveitis, occlusive retinal vascular disease, and age-related macular degeneration.Akiyama HideoNULLRecruiting>= 20age oldNot applicableBoth50N/AJapan
6ChiCTR2000041260
2021-01-012020-12-23The effects of norepinephrine and phenylephrine on cerebral oxygenation in treating intraoperative hypotension in STA-MCA bypass surgeryThe effects of norepinephrine and phenylephrine on cerebral oxygenation in treating intraoperative hypotension in STA-MCA bypass surgery moyamoya diseaseGroup 1:iv norepinephrine;Group 2:iv phenylephrine;The South District of Anhui Provincial HospitalNULLRecruiting1865BothGroup 1:30;Group 2:30;Phase 4China
7ChiCTR2000029878
2020-11-012020-02-16The effects of norepinephrine and phenylephrine on cerebral oxygenation in treating intraoperative hypotension in STA-MCA bypass surgeryThe effects of norepinephrine and phenylephrine on cerebral oxygenation in treating intraoperative hypotension in STA-MCA bypass surgery moyamoya diseaseGroup 1:iv norepinephrine;Group 2:iv phenylephrine;The South District of Anhui Provincial HospitalNULLPending1865BothGroup 1:30;Group 2:30;Phase 4China
8NCT04205578
(ClinicalTrials.gov)
January 202018/12/2019NBP in Patients With Moyamoya Disease of High Risk for Ischemic Cerebrovascular EventsA Multi-center, Randomized, Single-blind, Placebo-controlled Study of Dl-3-n-butylphthalide in Patients With Moyamoya Disease of High Risk for Ischemic Cerebrovascular Events After Extracranial-to-intracranial Revascularization SurgeryMoyamoya Disease;Ischemic Cerebral Infarction;Ischemic Stroke;Ischemic Cerebrovascular Accident;Transient Ischemic AttackDrug: dl-3-n-butylphthalide (NBP);Drug: Normal Saline 0.9% Infusion Solutionyuanli ZhaoPeking University International HospitalNot yet recruiting18 Years60 YearsAll450Phase 3China
9NCT04012268
(ClinicalTrials.gov)
July 15, 20193/7/2019The Safety and Efficacy of RIC on Adult Moyamoya DiseaseThe Safety and Effect of Remote Ischemic Conditioning on Adult Moyamoya DiseaseMoyamoya DiseaseDevice: RIC;Drug: AspirinCapital Medical UniversityNULLCompleted18 Years60 YearsAll30N/AChina
10ChiCTR1900027197
2019-05-012019-11-04Study on the protective effect of desflurane combined with propofol on the brain of patients with moyamoya disease undergoing cerebral revascularizationStudy for the protective effect of desflurane on the brain of patients with moyamoya disease Moyamoya diseaseGroup D:Desflurane for anesthesia maintenance;GroupP:Propofol;GroupPD:Desflurane and propofol;The First Affiliated Hospital of Zhengzhou UniversityNULLCompleted2065BothGroup D:30;GroupP:30;GroupPD:30;Phase 4China
11NCT03882060
(ClinicalTrials.gov)
April 8, 201912/3/2019Effect of Recombinant Human EPO on the Postoperative Neurologic Outcome in Pediatric Moyamoya PatientsThe Effect of Recombinant Human Erythropoietin on the Postoperative Neurologic Outcome in Pediatric Moyamoya Disease Patients - A Double Blind Randomized Controlled TrialMoyamoya Disease;Pediatrics;Cerebrovascular DisordersDrug: erythropoietin;Drug: Normal salineSeoul National University HospitalNULLActive, not recruitingN/A18 YearsAll60N/AKorea, Republic of
12ChiCTR1800020377
2019-01-012018-12-27Aspirin in Moyamoya DiseaseThe Clinical Benefit and Risk of Oral Aspirin for Moyamoya Disease moyamoya diseaseCase series:Aspirin;Beijing Tiantan Hospital, Capital Medical UniversityNULLRecruiting860BothCase series:300;China
13JPRN-jRCTs031180017
01/08/201807/09/2018Studies on the utility of simultaneous-multi-slice acquisition (SMS) dynamic susceptibility contrast-enhanced (DSC)MRI for the occulusive cerebrobascular diseaseStudies on the utility of simultaneous-multi-slice acquisition (SMS) dynamic susceptibility contrast-enhanced (DSC)MRI for the occulusive cerebrobascular disease - SMS DSC-MRI study for the occulusive cerebrobascular disease carotid artery stenosis, moyamoya diseaseIntravenous administration of gadobutrol (Gadovist, Bayer Schering Pharma, Berlin, Germany) is administered in the supine position, and high speed DSC-MRI scan by using SMS acquisition (temporal resolution of 0.5s) is carried out at the same time as injection of the contrast agent with an acquisition time of 70sec. The quantitative and qualitative comparison between reference data set (0.5s) and additional data sets with temporal resolution of 1.0s, 1.5s, and 2.0s generated from the reference data set, is performed.Aoki ShigekiBayer Yakuhin, Ltd;Bayer Yakuhin, LtdComplete>= 20age oldNot applicableBoth50N/AJapan
14NCT02510586
(ClinicalTrials.gov)
August 201524/7/2015Sevoflurane and Hyperperfusion SyndromeEffect of Sevoflurane-induced Postconditioning on the Incidence of Postoperative Cerebral Hyperperfusion Syndrome After Revascularization Surgery in Adult Patients With Moyamoya DiseaseHyperperfusion Syndrome;Moyamoya DiseaseDrug: SevofluraneSeoul National University HospitalNULLNot yet recruiting18 YearsN/ABoth152N/ANULL
15JPRN-UMIN000008742
2012/09/0121/08/2012Studies on the effect of free radical scavenger Edaravone against postoperative hyper-perfusion syndrome after STA-MCA bypass surgery for adult moyamoya disease.Studies on the effect of free radical scavenger Edaravone against postoperative hyper-perfusion syndrome after STA-MCA bypass surgery for adult moyamoya disease. - Studies on the effect of free radical scavenger Edaravone against postoperative hyper-perfusion syndrome after STA-MCA bypass surgery for adult moyamoya disease. moyamoya diseaseAdministration of edaravone from preoperative to postoperative day 7.Department of Neurosurgery, Hokkaido University Graduate School of MedicineNULLComplete: follow-up complete16years-oldNot applicableMale and Female32Not applicableJapan
16NCT03162588
(ClinicalTrials.gov)
May 1, 201018/5/2017Multiple Burrhole Therapy With Erythropoietin for Unstable MoyamoyaFeasibility Study of Multiple Burrhole Therapy Combined With Intravenous Erythropoietin Pretreatment for Unstable MoyamoyaIschemic Attack;Ischemic Stroke;Moyamoya Disease;Burr Hole;AngiogenesisDrug: erythropoietinAjou University School of MedicineNULLCompleted16 YearsN/AAll37Phase 1/Phase 2Korea, Republic of
17NCT01419275
(ClinicalTrials.gov)
April 200916/8/2011Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke PatientsQuantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke PatientsCerebrovascular Accident;Moyamoya DiseaseDrug: Xenon contrast agent;Device: Magnetic Resonance ImagingStanford UniversityNULLCompletedN/AN/AAll126N/AUnited States