25. Progressive multifocal leukoencephalopathy Clinical trials / Disease details
Clinical trials : 26 / Drugs : 35 - (DrugBank : 22) / Drug target genes : 8 - Drug target pathways : 37
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT00001048 (ClinicalTrials.gov) | February 1998 | 2/11/1999 | Comparison of Anti HIV Drugs Used Alone or in Combination With Cytosine Arabinoside to Treat Progressive Multifocal Leukoencephalopathy (PML) in HIV-Infected Patients | A Phase II Multicenter Study Comparing Antiretroviral Therapy Alone to Antiretroviral Therapy Plus Cytosine Arabinoside (Cytarabine; Ara-C) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in Human Immunodeficiency Virus (HIV)-Infected Subjects | HIV Infections;Leukoencephalopathy, Progressive Multifocal | Drug: Filgrastim;Drug: Cytarabine;Drug: Zidovudine;Drug: Zalcitabine;Drug: Didanosine | National Institute of Allergy and Infectious Diseases (NIAID) | Bristol-Myers Squibb;Upjohn | Completed | 18 Years | 65 Years | All | 90 | Phase 2 | United States |
| 2 | NCT00002270 (ClinicalTrials.gov) | October 1997 | 2/11/1999 | A Pilot Study of the Efficacy of Recombinant Alpha Interferon (IFN-A2b) and Zidovudine (AZT) in the Treatment of Progressive Multifocal Leukoencephalopathy (PML) Complicating HIV-1 Infection | A Pilot Study of the Efficacy of Recombinant Alpha Interferon (IFN-A2b) and Zidovudine (AZT) in the Treatment of Progressive Multifocal Leukoencephalopathy (PML) Complicating HIV-1 Infection | HIV Infections;Leukoencephalopathy, Progressive Multifocal | Drug: Interferon alfa-2b;Drug: Zidovudine | University of Miami | NULL | Completed | 18 Years | 65 Years | Both | N/A | United States | |
| 3 | NCT00002274 (ClinicalTrials.gov) | October 1997 | 2/11/1999 | A Study of ddI in Patients With AIDS Who Become Sicker While Taking Zidovudine | An Open Label Study Regimen of Videx (2',3'-Dideoxyinosine, ddI) in Patients With Acquired Immunodeficiency Syndrome (AIDS) Exhibiting Significant Deterioration While Taking Zidovudine (Retrovir) | HIV Infections;Leukoencephalopathy, Progressive Multifocal | Drug: Didanosine | Bristol-Myers Squibb | NULL | Completed | 12 Years | N/A | Both | N/A | United States |