279. Huge venous malformation with cervical, oral and pharyngeal diffuse lesion Clinical trials / Disease details

Clinical trials : 15 / Drugs : 24 - (DrugBank : 10) / Drug target genes : 3 - Drug target pathways : 105

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100053242	2022-06-12	2021-11-17	Clinical study on the safety and efficacy of fibrin glue combined with local injection of pingyangmy ...	A prospective, open-label, single-arm, phase II clinical trial to evaluate the efficacy of pingyangm ...	Head and Neck Venous Malformation	Experimental group:Pingyangmycin combined with local injection of fibrin glue;	The First Affiliated Hospital of Sun Yat-Sen University	NULL	Recruiting	1	70	Both	Experimental group:20;	Phase 2	China
2	NCT04861064 (ClinicalTrials.gov)	January 18, 2022	23/4/2021	Weekly Sirolimus Therapy	Weekly Sirolimus Therapy for the Treatment of Venous and Lymphatic Malformations	Venous Malformation;Lymphatic Malformation	Drug: Sirolimus	Medical University of South Carolina	NULL	Recruiting	2 Years	N/A	All	24	Phase 2	United States
3	ChiCTR2100052762	2021-11-01	2021-11-05	Efficacy and safety of topical sirolimus and laser in the treatment of verrucous venous malformation ...	Efficacy and safety of topical sirolimus and laser in the treatment of verrucous venous malformation ...	Verrucous Venous Malformation	group 1:topical sirolimus ;group 2:laser ;	Shanghai Ninth People's Hospital	NULL	Pending	0	65	Both	group 1:25;group 2:25;		China
4	JPRN-jRCT2051200046	15/01/2021	25/08/2020	A study for evaluation of efficacy and safety of ethanolamine oleate in patients with venous malform ...	Evaluation of efficacy and safety of ethanolamine oleate in sclerotherapy in patients with venous ma ...	Venous malformation difficult to remove	Injection of 5% ethanolamine oleatewhich is double diluted by contrast or normal saline for the venou ...	Nomura Tadashi	Nomura Tadashi;Ozaki Mine	Recruiting	Not applicable	Not applicable	Both	44	Phase 3	Japan
5	JPRN-jRCTs061200036	11/12/2020	11/12/2020	Prospective trial to verify the efficacy and safety of sclerotherapy with polidocanol for painful ve ...	A single-center, one-arm, prospective, openlabel trial to verify the efficacy and safety of scleroth ...	Painful venous malformations	Sclerotherapy with polidocanol	Uka Mayu	NULL	Recruiting	>= 12age old	Not applicable	Both	13	N/A	Japan
6	NCT04258046 (ClinicalTrials.gov)	March 31, 2020	16/1/2020	Trametinib in the Treatment of Complicated Extracranial Arterial Venous Malformation	Phase II Clinical Trial of MEK Inhibitor Trametinib in the Treatment of Complicated Extracranial Art ...	Venous Malformation;Arterial Disease	Drug: Trametinib tablet	Stanford University	Boston Children's Hospital	Not yet recruiting	12 Years	60 Years	All	30	Phase 2	United States
7	NCT04930952 (ClinicalTrials.gov)	February 28, 2019	11/6/2021	Complications of Ethanol-amine Oleate Intralesional Sclerotherapy	Complications of Ethanol-amine Oleate Intralesional Sclerotherapy Injections of Maxillofacial Venous ...	Venous Malformation	Drug: Ethanol -amine Oleate Sclerotherapy Injection	Suez Canal University	NULL	Completed	N/A	12 Years	All	15		Egypt
8	NCT03767660 (ClinicalTrials.gov)	July 31, 2018	24/11/2018	Efficacy of Rapamycin (Sirolimus) in the Treatment of BRBNS, Hereditary or Sporadic Venous Malformat ...	Efficacy of Rapamycin (Sirolimus) in the Treatment of Blue Rubber Bleb Nevus Syndrome, Hereditary or ...	Blue Rubber Bleb Nevus Syndrome;Venous Malformation	Drug: Rapamycin	Peking Union Medical College Hospital	Air Force General Hospital of the PLA;Chinese Academy of Medical Sciences	Recruiting	N/A	N/A	All	20	Phase 4	China
9	ChiCTR-OIB-15007455	2015-03-18	2015-11-24	Effect of sclerotherapy on venous malformationassociated with localized intravascular coagulopathy: ...	Effect of sclerotherapy on venous malformationassociated with localized intravascular coagulopathy: ...	venous malformation	1:sclerotherapy with ethanol;	Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine	NULL	Recruiting			Both	1:40;	I (Phase 1 study)	China
10	EUCTR2011-001455-37-NO (EUCTR)	21/12/2011	01/06/2011	Prospective randomized interventional study in patients with venous malformations.	Prospective randomized interventional study. Compare the effect of bleomycin and Tetradecyl Sodium S ...	Venous malformation MedDRA version: 13.1;Level: LLT;Classification code 10047229;Term: Venous malfor ...	Trade Name: Bleomycin Baxter Product Name: Bleomycin Trade Name: Fibrovein 3% Product Name: Fibrovein 3%	Department of Radiology, Oslo University Hospital, Norway	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Norway

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