279. Huge venous malformation with cervical, oral and pharyngeal diffuse lesion Clinical trials / Disease details
Clinical trials : 15 / Drugs : 24 - (DrugBank : 10) / Drug target genes : 3 - Drug target pathways : 105
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04861064 (ClinicalTrials.gov) | January 18, 2022 | 23/4/2021 | Weekly Sirolimus Therapy | Weekly Sirolimus Therapy for the Treatment of Venous and Lymphatic Malformations | Venous Malformation;Lymphatic Malformation | Drug: Sirolimus | Medical University of South Carolina | NULL | Recruiting | 2 Years | N/A | All | 24 | Phase 2 | United States |
| 2 | ChiCTR2100052762 | 2021-11-01 | 2021-11-05 | Efficacy and safety of topical sirolimus and laser in the treatment of verrucous venous malformations | Efficacy and safety of topical sirolimus and laser in the treatment of verrucous venous malformations | Verrucous Venous Malformation | group 1:topical sirolimus ;group 2:laser ; | Shanghai Ninth People's Hospital | NULL | Pending | 0 | 65 | Both | group 1:25;group 2:25; | China | |
| 3 | NCT03767660 (ClinicalTrials.gov) | July 31, 2018 | 24/11/2018 | Efficacy of Rapamycin (Sirolimus) in the Treatment of BRBNS, Hereditary or Sporadic Venous Malformation | Efficacy of Rapamycin (Sirolimus) in the Treatment of Blue Rubber Bleb Nevus Syndrome, Hereditary or Sporadic Venous Malformation | Blue Rubber Bleb Nevus Syndrome;Venous Malformation | Drug: Rapamycin | Peking Union Medical College Hospital | Air Force General Hospital of the PLA;Chinese Academy of Medical Sciences | Recruiting | N/A | N/A | All | 20 | Phase 4 | China |
| 4 | NCT00975819 (ClinicalTrials.gov) | October 2009 | 10/9/2009 | Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies | A Phase 2 Study - Clinical Trial Assessing Efficacy and Safety of the mTOR Inhibitor Sirolimus in the Treatment of Complicated Vascular Anomalies | Kaposiform Hemangioendotheliomas;Tufted Angioma;Capillary Venous Lymphatic Malformation;Venous Lymphatic Malformation;Microcystic Lymphatic Malformation;Mucocutaneous Lymphangiomatosis and Thrombocytopenia;Capillary Lymphatic Arterial Venous Malformations;PTEN Overgrowth Syndrome With Vascular Anomaly;Lymphangiectasia Syndromes | Drug: sirolimus | Children's Hospital Medical Center, Cincinnati | NULL | Active, not recruiting | N/A | 31 Years | Both | 60 | Phase 2 | United States |