333. Hutchinson-Gilford syndrome Clinical trials / Disease details

Clinical trials : 8 / Drugs : 8 - (DrugBank : 3) / Drug target genes : 4 - Drug target pathways : 6

5 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2100050052	2021-09-01	2021-08-16	Observational study of Lonafarnib in Chinese patients with progeria and progeroid laminopathy	Observational study of Lonafarnib in Chinese patients with progeria and progeroid laminopathy	Hutchinson-Gilford Progeria Syndrome and Progeroid Laminopathies	Experimental group:Treatment with Lonafarnib;	The Children's Hospital Zhejiang University School of Medicine	NULL	Pending	1	99	Both	Experimental group:25;	N/A	China
2	NCT03895528 (ClinicalTrials.gov)	June 8, 2020	27/3/2019	Lonafarnib for Patients With Hutchinson-Gilford Progeria Syndrome or Progeroid Laminopathy	A Treatment IND (Investigational New Drug) Protocol for EAP (Expanded Access Program) for the Use of ...	Progeria;HGPS	Drug: Lonafarnib	Eiger BioPharmaceuticals	NULL	Approved for marketing	12 Months	N/A	All			NULL
3	NCT00916747 (ClinicalTrials.gov)	August 2009	5/6/2009	Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria	An Open Label Phase II Trial of Zoledronic Acid, Pravastatin, and Lonafarnibfor Patients With Hutchi ...	Progeria	Drug: Lonafarnib , Zoledronic Acid, and Pravastatin	Boston Children's Hospital	Schering-Plough;Merck Sharp & Dohme LLC;Eiger BioPharmaceuticals	Active, not recruiting	N/A	N/A	All	85	Phase 2	United States
4	NCT00879034 (ClinicalTrials.gov)	March 2009	8/4/2009	A Study of Zoledronic Acid, Pravastatin, and Lonafarnib for Patients With Progeria	A Phase II Pilot Study of Zoledronic Acid, Pravastatin, and Lonafarnib(SCH66336) for Patients With H ...	Progeria;Hutchinson-Gilford Syndrome	Drug: Lonafarnib;Drug: Zoledronic Acid;Drug: Pravastatin	Boston Children's Hospital	Dana-Farber Cancer Institute;Brigham and Women's Hospital;Schering-Plough	Completed	N/A	N/A	All	5	Phase 2	United States
5	NCT00425607 (ClinicalTrials.gov)	May 2007	22/1/2007	Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria	An Open Label Dose Adjusted Phase II Trial of the Oral Farnesyltransferase Inhibitor (FTI) Lonafarni ...	Progeria;Hutchinson-Gilford Syndrome	Drug: Lonafarnib	Monica E. Kleinman	Schering-Plough	Completed	1 Year	N/A	All	29	Phase 2	United States

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