38. Stevens-Johnson syndrome Clinical trials / Disease details

Clinical trials : 17 / Drugs : 29 - (DrugBank : 9) / Drug target genes : 15 - Drug target pathways : 101

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02987257 (ClinicalTrials.gov)	March 15, 2023	25/11/2016	NATIENS: Optimal Management and Mechanisms of SJS/TEN	NATIENS: A Phase III Randomized Double-Blinded Placebo Controlled Study to Determine the Optimal Man ...	Stevens-Johnson Syndrome;Toxic Epidermal Necrolyses	Drug: Harmonized supportive care;Drug: Cyclosporine 5 mg/kg bid days 0-14;Drug: Etanercept 50 mg sc da ...	Vanderbilt University Medical Center	University of Ottawa;University of Toronto	Not yet recruiting	18 Years	N/A	All	267	Phase 3	United States
2	NCT05520086 (ClinicalTrials.gov)	November 11, 2022	22/8/2022	Clinical Trial to Evaluate Safety and Efficacy of Cell Therapy in Patients With Cicatricial Conjunti ...	Phase IIa Multicenter Clinical Trial to Determine the Feasibility and Safety of the Use of Adipose-d ...	Chronic Conjunctivitis;Stevens-Johnson Syndrome;Lyell Syndrome;Pemphigoid	Drug: Single Dose;Drug: Double Dose	Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz	Effice Servicios Para la Investigacion S.L.	Recruiting	18 Years	N/A	All	20	Phase 1/Phase 2	Spain
3	EUCTR2021-005486-40-ES (EUCTR)	22/07/2022	11/02/2022	Clinical Trial to evaluate safety and efficacy of cell therapy in patients with cicatricial conjunti ...	Phase IIa multicenter clinical trial to determine the feasibility and safety of the use of adipose-d ...	Cicatricial conjunctivitis associated with Lyell's syndrome, Stevens-Johnson syndromeand mucous memb ...	Product Name: allogenic mesenchymal stem cell isolated from adipose tissue INN or Proposed INN: ALLOG ...	FUNDACION JIMENEZ DIAZ HEALTH RESEARCH INSTITUTE	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	20	Phase 2	Spain
4	JPRN-jRCTs031210325	01/10/2021	17/09/2021	Etanercept therapy for Stevens-Johnson syndrome(SJS) and toxic epidermal necrolysis (TEN) cases of r ...	open-label, multicenter, single-arm study to evaluate the efficacy and safety of etanercept in patie ...	stevens-johnson syndrome, toxic epidermal necrosis stevens-johnson syndrome, toxic epidermal necrosi ...	Etanercept50 mg / day is subcutaneously administered on the first day (Day 1). If epithelialization ...	Abe Riichirou	NULL	Recruiting	>= 20age old	Not applicable	Both	10	Phase 2	Japan
5	EUCTR2020-003544-83-FR (EUCTR)	16/03/2021	08/01/2021	Evaluation de l’efficacité thérapeutique du filgrastim dans les allergies sévères bulleuses aux médi ...	Evaluation de l’efficacité thérapeutique du filgrastim dans les allergies sévères bulleuses aux médi ...	Syndrome de Stevens Johnson (SJS)Syndrome de Lyell (NET) MedDRA version: 20.1;Level: LLT;Classificat ...	Trade Name: ZARZIO INN or Proposed INN: FILGRASTIM	Hospices Civils de Lyon - Direction de la Recherche Clinique	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	42	Phase 2;Phase 3	France
6	NCT03585946 (ClinicalTrials.gov)	January 1, 2021	14/3/2018	Outcomes in Stevens Johnsons Syndrome and Toxic Epidermal Necrolysis	A Prospective Multicenter Cohort Study Assessing Outcomes in Stevens Johnsons Syndrome and Toxic Epi ...	Stevens-Johnson Syndrome;Toxic Epidermal Necrolysis;Drug Reaction	Drug: Site specific standard of care comparison	Massachusetts General Hospital	NULL	Not yet recruiting	18 Years	N/A	All	750		NULL
7	JPRN-jRCTs061180044	01/06/2017	12/03/2019	Multicenter Open-trial of Steroid pulse therapy for SJS/TEN	Multicenter Open-trial of Steroid pulse therapy for SJS/TEN - MOSST Study	Stevens-Johnson syndrome and Toxic epidermal necrolysis	1. infusion of methylprednisoloneat 500~1000 mg/d (0.9% N/S in 3 hour) for 3 consecutive days. 2. Oral ...	Morita Eishin	NULL	Complete	>= 20age old	<= 90age old	Both	20	Phase 2	Taiwan;Germany;Japan
8	NCT05284929 (ClinicalTrials.gov)	May 17, 2017	10/3/2022	Human Leukocyte Antigen Class II (DRB1 and DQB1) Alleles and Haplotypes Frequencies in Patients With ...	Increased Frequencies of Certain HLA Class II Alleles DRB1 and DQB1 in PV Patients Compared to Those ...	Pemphigus;Bullous Pemphigoid;Stevens-Johnson Syndrome;Toxic Epidermal Necrolyses	Genetic: A single blood sample for HLA typing	Sechenov University	Pirogov Russian National Research Medical University	Recruiting	N/A	N/A	All	120		Russian Federation
9	NCT03046914 (ClinicalTrials.gov)	February 24, 2016	6/2/2017	HLA-B*5801 Screening to Prevent Allopurinol-induced Severe Cutaneous Adverse Reaction	A Prospective Study to Prove the Usefulness of HLA-B*5801 Screening Test for the Prevention of Allop ...	Stevens-Johnson Syndrome;Kidney Failure, Chronic	Genetic: HLA-B*5801 test	Seoul National University Hospital	Ministry of Food and Drug Safety, Korea	Recruiting	N/A	N/A	All	600	N/A	Korea, Republic of
10	NCT02126020 (ClinicalTrials.gov)	November 2014	27/4/2014	Topical Infliximab in Autoimmune Eyes With Keratoprosthesis	Topical Infliximab in Autoimmune Eyes With Keratoprosthesis	Stevens-Johnson Syndrome;Toxic Epidermal Necrolysis (Lyell) Syndrome;Mucous Membrane Pemphigoid	Drug: topical infliximab	James Chodosh, MD, MPH	Massachusetts Eye and Ear Infirmary;Fonds de recherche en ophtalmologie de l'Université de Montréal ...	Withdrawn	18 Years	80 Years	All	0	Phase 1/Phase 2	United States;Canada

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