46. Malignant rheumatoid arthritis Clinical trials / Disease details

Clinical trials : 4,356 / Drugs : 2,567 - (DrugBank : 415) / Drug target genes : 192 - Drug target pathways : 228

140 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05165771 (ClinicalTrials.gov)	July 2022	8/12/2021	Study to Evaluate Safety, Tolerability, and Efficacy of GS-5718 in Participants With Active Rheumato ...	A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 2 Proof-of-Concept Study to Evalu ...	Rheumatoid Arthritis	Drug: GS-5718;Drug: Placebo to match GS-5718;Drug: Tofacitinib 5 mg;Drug: Placebo to match Tofacitini ...	Gilead Sciences	NULL	Withdrawn	18 Years	75 Years	All	0	Phase 2	NULL
2	NCT05606107 (ClinicalTrials.gov)	May 20, 2022	1/11/2022	To Compare the Efficacy and Safety of Low-dose Glucocorticoids and Tofacitinibin Alleviating Moderat ...	To Compare the Efficacy and Safety of Low-dose Glucocorticoids and Tofacitinibin Alleviating Moderat ...	Rheumatoid Arthritis	Drug: Tofacitinib;Drug: Glucocorticoid	Second Affiliated Hospital, School of Medicine, Zhejiang University	Jiaxing Hospital of T.C.M;Jinhua Municipal Central Hospital;SAHZU.CHANGXING CAMPUS;Zhuji People's ho ...	Recruiting	18 Years	70 Years	All	230	Phase 4	China
3	NCT05246293 (ClinicalTrials.gov)	April 1, 2022	17/1/2022	Tofacitinib in the Treatment of Rheumatoid Arthritis-related Interstitial Lung Disease.	Safety and Tolerability of Tofacitinibin the Treatment of Rheumatoid Arthritis-related Interstitial ...	Rheumatoid Arthritis;Interstitial Lung Disease	Drug: Tofacitinib	National Institute of Respiratory Diseases, Mexico	NULL	Recruiting	18 Years	N/A	All	60	Phase 2	Mexico
4	NCT05133297 (ClinicalTrials.gov)	February 16, 2022	15/11/2021	The Safety and Efficacy of TLL-018 in Active Rheumatoid Arthritis	A Phase 2A, Randomized, Double-blind, Double-dummy, Tofacitinib-parallel-group Study to Evaluate the ...	Rheumatoid Arthritis	Drug: TLL-018;Drug: Tofacitinib	Hangzhou Highlightll Pharmaceutical Co., Ltd	NULL	Recruiting	18 Years	75 Years	All	100	Phase 2	China
5	EUCTR2021-004131-84-NL (EUCTR)	14/02/2022	08/09/2021	Comparing the effectiveness of tofacitinibextended release (XR) chronotherapy, morning versus evenin ...	Chronotherapy in Inflammatory Arthritis (ChronIA trial): a crossover randomized controlled trial com ...	Rheumatoid arthritis or psoriatic arthritis according to respectively 2010 criteria or CASPAR criter ...	Trade Name: Xeljanz XR Product Name: Tofacitinib XR Product Code: EMEA/H/C/004214	Erasmus Medical Center	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	84	Phase 4	Netherlands
6	NCT04876781 (ClinicalTrials.gov)	January 12, 2022	20/4/2021	Korean Post-marketing Surveillance for Xeljanz XR	Korean Post-marketing Surveillance for Xeljanz XR (Registered)	Active Moderate to Severe Rheumatoid Arthritis;Active Ankylosing Spondylitis	Drug: Tofacitinib XR	Pfizer	NULL	Recruiting	18 Years	N/A	All	200		Korea, Republic of
7	ChiCTR2100054220	2021-12-04	2021-12-11	Efficacy and safety of tofacitinibin the treatment of rheumatoid arthritis related interstitial lung ...	Efficacy and safety of tofacitinibin the treatment of rheumatoid arthritis related interstitial lung ...	Rheumatoid arthritis related interstitial lung disease	Tofacitinib group:No;Traditional immunosuppressive therapy group:No;	Yantai Yuhuangding Hospital	NULL	Recruiting	18	90	Both	Tofacitinib group:30;Traditional immunosuppressive therapy group:30;	Phase 4	Chian
8	NCT05080218 (ClinicalTrials.gov)	November 15, 2021	6/10/2021	COVID-19 VaccinE Response in Rheumatology Patients	The SARS-CoV-2 Vaccine Response and Safety in Rheumatology Patients and the Influence of Temporary I ...	Rheumatoid Arthritis;Psoriatic Arthritis;Spondylarthritis	Drug: Upadacitinib;Drug: Abatacept;Drug: Secukinumab;Drug: Tofacitinib;Drug: TNF Inhibitor;Drug: Can ...	Jeffrey Curtis	University of Alabama at Birmingham;University of Nebraska;University of Pennsylvania;AbbVie;Bristol ...	Recruiting	18 Years	85 Years	All	1000	Phase 4	United States
9	EUCTR2021-001560-14-ES (EUCTR)	13/08/2021	11/06/2021	Use of tofacitinib in patients with treatment-refractory rheumatoid arthritis.	Single-center, open-label, uncontrolled clinical trial to evaluate the association between the expre ...	Refractory rheumatoid arthritis;Therapeutic area: Diseases [C] - Immune System Diseases [C20]	Trade Name: XELJANZ INN or Proposed INN: TOFACITINIB	FUNDACION JIMENEZ DIAZ HEALTH RESEARCH INSTITUTE	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	42	Phase 4	Spain
10	ChiCTR2100048185	2021-07-01	2021-07-04	The efficacy and safety of Tofacitinib in the treatment of DMARDS naive rheumatoid arthtits patients	The efficacy and safety of Tofacitinibvirus MTX in the treatment of DMARDS naive rheumatoid arthtits ...	Rheumatoid Arthritis	Experimental group:Tofacitinib 5mg twice per day;Control group:Methotrexate;	Peking University First Hospital	NULL	Pending	18		Both	Experimental group:112;Control group:112;	Phase 4	China

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