60. Aplastic anemia Clinical trials / Disease details

Clinical trials : 245 / Drugs : 318 - (DrugBank : 86) / Drug target genes : 44 - Drug target pathways : 166

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05323617 (ClinicalTrials.gov)	May 15, 2023	5/4/2022	Efficacy of Romiplostim in Treatment of SAA in Adults Previously Untreated With or Refractory to Imm ...	Two Arm Bridging Study to Evaluate the Efficacy of Romiplostim in the Treatment of Adult Severe Apla ...	Severe Aplastic Anemia (SAA)	Drug: Romiplostim;Drug: Antithymocyte Globulin;Drug: Cyclosporine A	Amgen	NULL	Not yet recruiting	18 Years	N/A	All	40	Phase 2	NULL
2	NCT05600426 (ClinicalTrials.gov)	January 25, 2023	20/10/2022	A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Ap ...	A Phase III Randomized Trial Comparing Unrelated Donor Bone Marrow Transplantation With Immune Suppr ...	Severe Aplastic Anemia	Drug: cyclosporine;Procedure: Matched Unrelated Donor Hematopoetic Stem Cell Transplant;Drug: horse ...	Boston Children's Hospital	Center for International Blood and Marrow Transplant Research;National Institutes of Health (NIH);Na ...	Recruiting	0 Years	25 Years	All	234	Phase 3	United States
3	ChiCTR2200056659	2023-01-16	2022-02-10	Allopurinol in the treatment of cyclosporine-induced hyperuricemia in children with aplastic anemia: ...	Allopurinol in the treatment of cyclosporine-induced hyperuricemia in children with aplastic anemia: ...	hyperuricemia	Allopurinol group:Receive allopurinol tablets;Placebo group:Receive placebo;	The Seventh Affiliated Hospital, Sun Yat-sen University	NULL	Pending	1	18	Both	Allopurinol group:20;Placebo group:20;	Phase 4	China
4	NCT05660785 (ClinicalTrials.gov)	December 1, 2022	23/11/2022	Herombopag Added to Cyclosporine in Non Severe Aplastic Anemia	The Efficacy and Safety of Herombopag Combined With Cyclosporine for Patients With Non Severe Aplast ...	Non Severe Aplastic Anemia;Untreated	Drug: Herombopag	Institute of Hematology & Blood Diseases Hospital	Jiangsu Hengrui Pharmaceuticals Co.,Ltd	Recruiting	18 Years	N/A	All	54	Phase 2	China
5	NCT05720234 (ClinicalTrials.gov)	November 10, 2022	11/1/2023	Avatrombopag Combined With IST as First-line Treatment for SAA	The Efficacy and Safety Study of Avatrombopag Combined With IST as First-line Treatment for Severe A ...	Severe Aplastic Anemia	Drug: avatrombopag	Institute of Hematology & Blood Diseases Hospital	NULL	Recruiting	12 Years	60 Years	All	53	Phase 2	China
6	NCT05399732 (ClinicalTrials.gov)	July 2022	24/5/2022	Efficacy and Safety in Transfusion Independent Non-severe Aplastic Anemia	A Randomized, Case Controlled Clinical Trial Evaluating the Efficiency and Safety of Luspatercept Pl ...	Aplastic Anemia	Drug: Luspatercept	Bing Han	NULL	Not yet recruiting	18 Years	80 Years	All	90	Phase 2	China
7	NCT05571332 (ClinicalTrials.gov)	June 28, 2022	28/8/2022	Efficacy and Safety of Avatrombopag Combined With IST for the Treatment of HAAA and SAA With Abnorma ...	Efficacy and Safety of Avatrombopag Combined With IST for the Treatment of HAAA and SAA With Abnorma ...	Aplastic Anemia	Drug: Avatrombopag 20 MG Oral Tablet	Institute of Hematology & Blood Diseases Hospital	NULL	Recruiting	18 Years	70 Years	All	39	N/A	China
8	NCT05531279 (ClinicalTrials.gov)	June 5, 2022	2/9/2022	A Study of PEG-rhG-CSF and rhG-CSF Used for Aplastic Anemia Granulocyte Deficiency	A Randomized,Open-label Dose-discovery Study of PEG-rhG-CSF and rhG-CSF in the Adjuvant Therapy of A ...	Severe Aplastic Anemia	Drug: PEG -rhG-CSF	Institute of Hematology & Blood Diseases Hospital	NULL	Recruiting	18 Years	70 Years	All	45	N/A	China
9	ChiCTR2200060098	2022-05-05	2022-05-18	A retrospective study to assess the efficacy and safety of eltrombopag in combination with immunosup ...	A retrospective study to assess the efficacy and safety of eltrombopag in combination with immunosup ...	Aplastic anemia	Experimental group:Eltrombopag combined with immunosuppressive therapy (IST);Control group:IST;	The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine	NULL	Pending	16	80	Both	Experimental group:132;Control group:66;	Phase 4	China
10	NCT05333861 (ClinicalTrials.gov)	May 1, 2022	11/4/2022	An Observational, Multicenter Study to Evaluate the Safety and Effectiveness of Hetrombopag in Patie ...	An Observational, Multicenter Study to Evaluate the Safety and Effectiveness of Hetrombopag in Patie ...	Primary Immune Thrombocytopenia;Aplastic Anemia	Drug: hetrombopag	Wuhan Union Hospital, China	Jiangsu Hengrui Pharmaceutical Co., Ltd.	Not yet recruiting	N/A	N/A	All	1150		China

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