65. Primary immunodeficiency Clinical trials / Disease details

Clinical trials : 500 / Drugs : 614 - (DrugBank : 119) / Drug target genes : 92 - Drug target pathways : 217

15 trials found

diseases per page:

Showing 1 to 10 of 15 diseases

Filter by

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05463133 (ClinicalTrials.gov)	July 8, 2022	15/7/2022	Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an A ...	Phase I/II Study Using Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous ...	Chronic Granulomatous Disease	Drug: Sirolimus;Drug: Cyclophosphamide;Drug: Alemtuzumab;Drug: Busulfan;Biological: Pheripheral bloo ...	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Recruiting	4 Years	65 Years	All	50	Phase 1/Phase 2	United States
2	NCT04339777 (ClinicalTrials.gov)	September 22, 2020	8/4/2020	Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity	A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of ...	Lymphoproliferative Disorders;Autoimmune Lymphoproliferative;Immune System Diseases;Common Variable ...	Drug: Busulfan test dose;Drug: Fludarabine;Drug: Busulfan;Drug: Alemtuzumab;Radiation: Total body Irr ...	National Cancer Institute (NCI)	NULL	Recruiting	4 Years	69 Years	All	66	Phase 2	United States
3	NCT03910452 (ClinicalTrials.gov)	October 28, 2019	9/4/2019	Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Bus ...	Haploidentical Transplant for Patients With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, B ...	Chronic Granulomatous Disease	Drug: Busulfan;Drug: Alemtuzumab;Drug: Cyclophosphamide;Drug: Sirolimus;Radiation: Total Body Irradi ...	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Recruiting	4 Years	65 Years	All	30	Early Phase 1	United States
4	EUCTR2018-001489-41-SE (EUCTR)	02/07/2018	08/05/2018	A clinical trial using cell transplantation as treatment for bone marrow failure due to dyskeratosis ...	Radiation- and alkylator-free hematopoietic cell transplantation for bone marrow failure due to dysk ...	Dyskeratosis congenita / telomere disease MedDRA version: 20.0;Level: PT;Classification code 1000175 ...	Trade Name: Lemtrada INN or Proposed INN: Alemtuzumab Other descriptive name: ALEMTUZUMAB Trade Name: F ...	Karolinska Universitetssjukhuset	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	40	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	United States;Sweden
5	NCT02629120 (ClinicalTrials.gov)	December 17, 2015	10/12/2015	High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patie ...	High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patie ...	Chronic Granulomatous Disease Transplant	Drug: Alemtuzumab;Drug: Busulfan;Drug: Sirolimus;Drug: Cyclophosphamide;Radiation: Total Body Irradi ...	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Active, not recruiting	4 Years	65 Years	All	44	Phase 1/Phase 2	United States
6	NCT02162420 (ClinicalTrials.gov)	January 10, 2015	10/6/2014	Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia	Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia	Dyskeratosis Congenita;Aplastic Anemia	Drug: Alemtuzumab;Drug: Fludarabine;Drug: Cyclophosphamide;Radiation: Total Body Irradiation;Biologi ...	Masonic Cancer Center, University of Minnesota	NULL	Recruiting	0 Years	70 Years	All	50	N/A	United States
7	NCT01962415 (ClinicalTrials.gov)	February 4, 2014	10/10/2013	Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT	A Phase II Study of Reduced Intensity Conditioning in Pediatric Patients and Young Adults =55 Years ...	Primary Immunodeficiency (PID);Congenital Bone Marrow Failure Syndromes;Inherited Metabolic Disorder ...	Drug: Hydroxyurea;Drug: Alemtuzumab;Drug: Fludarabine;Drug: Melphalan;Drug: Thiotepa	Paul Szabolcs	NULL	Recruiting	2 Months	55 Years	All	100	Phase 2	United States
8	NCT01821781 (ClinicalTrials.gov)	March 2013	19/3/2013	Immune Disorder HSCT Protocol	A Study of Hematopoietic Stem Cell Transplantation (HSCT) in Immune Function Disorders Using a Reduc ...	Immune Deficiency Disorders;Severe Combined Immunodeficiency;Chronic Granulomatous Disease;X-linked ...	Drug: Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan	Washington University School of Medicine	NULL	Recruiting	N/A	21 Years	All	20	Phase 2	United States
9	NCT01652092 (ClinicalTrials.gov)	September 4, 2012	25/7/2012	Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies	Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies	SCID;Omenn's Syndrome;Reticular Dysgenesis;Wiskott-Aldrich Syndrome;Bare Lymphocyte Syndrome;Common ...	Drug: Alemtuzumab 0.3 mg;Drug: Cyclophosphamide;Drug: Busulfan;Biological: Stem Cell Transplantation; ...	Masonic Cancer Center, University of Minnesota	NULL	Recruiting	N/A	50 Years	All	30	N/A	United States
10	NCT01659606 (ClinicalTrials.gov)	July 2012	6/8/2012	Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Con ...	Radiation- and Alkylator-free Hematopoietic Cell Transplantation for Bone Marrow Failure Due to Dysk ...	Dyskeratosis Congenita;Hoyeraal Hreidarsson Syndrome;Revesz Syndrome;Aplastic Anemia	Biological: alemtuzumab;Drug: Fludarabine;Drug: Cyclosporins;Drug: Mycophenolate mofetil;Drug: Tacrol ...	Boston Children's Hospital	Dana-Farber Cancer Institute;Children's Hospital Medical Center, Cincinnati;Children's Hospital Los ...	Active, not recruiting	30 Days	65 Years	All	40	Phase 2	United States;Norway;Sweden

First Previous1 2Next Last