72. Pituitary ADH secretion disorder Clinical trials / Disease details

Clinical trials : 41 / Drugs : 27 - (DrugBank : 8) / Drug target genes : 7 - Drug target pathways : 10

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04789148 (ClinicalTrials.gov)	June 2023	5/3/2021	Effects of Intranasal Oxytocin in Patients With Central Diabetes Insipidus	Effects of Intranasal Oxytocin in Patients With Central Diabetes Insipidus - A Pilot Study	Central Diabetes Insipidus	Drug: Oxytocin nasal spray	Elizabeth Austen Lawson	NULL	Not yet recruiting	18 Years	60 Years	All	30	Phase 1	United States
2	NCT05319301 (ClinicalTrials.gov)	April 1, 2022	17/3/2022	Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)	Identification and Clinical Relevance of an Oxytocin Deficient State Following Melatonin Administrat ...	Oxytocin Deficiency;Hypopituitarism;Hypothalamic Obesity;Pituitary Dysfunction;Central Diabetes Insi ...	Dietary Supplement: Melatonin	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	NULL	Not yet recruiting	18 Years	N/A	All	40	N/A	Spain
3	NCT04588207 (ClinicalTrials.gov)	March 29, 2022	7/10/2020	Urea for Chronic Hyponatremia	Urea for Chronic Hyponatremia: A Pilot Study	Hyponatremia;Inappropriate ADH Syndrome	Drug: Urea	Helbert Rondon Berrios, MD, MS	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Recruiting	18 Years	N/A	All	30	Phase 2	United States
4	NCT04897802 (ClinicalTrials.gov)	September 13, 2021	17/5/2021	Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)	Identification and Clinical Relevance of an Oxytocin Deficient State: a Randomized, Crossover, Place ...	Hypopituitarism;Central Diabetes Insipidus;Panhypopituitarism;Psychological Disorder;Social Isolatio ...	Drug: Experimental: GLP1-RA (exenatide) administration;Drug: Control: Placebo administration	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	Instituto de Salud Carlos III	Recruiting	18 Years	65 Years	All	52	Phase 4	Spain
5	NCT04902235 (ClinicalTrials.gov)	July 6, 2021	17/5/2021	Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)	Identification and Clinical Relevance of an Oxytocin Deficient State: a Randomized, Crossover, Place ...	Hypopituitarism;Central Diabetes Insipidus;Panhypopituitarism;Psychological Disorder;Social Isolatio ...	Drug: Experimental: CRH administration;Drug: Control: Placebo administration	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	Instituto de Salud Carlos III	Recruiting	18 Years	65 Years	All	52	Phase 4	Spain
6	NCT04790175 (ClinicalTrials.gov)	March 29, 2021	25/2/2021	Samsca Post-marketing General Drug Use-results Survey in Patients With Hyponatremia in SIADH	Samsca Post-marketing General Drug Use-results Survey in Patients With Hyponatremia in Syndrome of I ...	Antidiuretic Hormone, Inappropriate Secretion	Drug: Tolvaptan (SAMSCA)	Otsuka Pharmaceutical Co., Ltd.	NULL	Recruiting	N/A	N/A	All	300		Japan
7	NCT04447911 (ClinicalTrials.gov)	February 4, 2021	10/6/2020	Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremi ...	Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremi ...	Hyponatremia;SIADH;Liver Failure;Kidney Failure	Drug: Empagliflozin 25 MG;Drug: Placebo	University Hospital, Basel, Switzerland	Luzerner Kantonsspital;Centre Hospitalier Universitaire Vaudois	Recruiting	18 Years	N/A	All	172	Phase 4	Switzerland
8	NCT04552873 (ClinicalTrials.gov)	December 3, 2020	10/9/2020	Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage	Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage	Hyponatremia;Subarachnoid Hemorrhage;SIADH	Drug: Urea;Other: PLACEBO	University Hospital, Grenoble	NULL	Recruiting	18 Years	N/A	All	52	N/A	France
9	NCT03202667 (ClinicalTrials.gov)	December 15, 2017	27/6/2017	Effects of the SGLT2-inhibitor Empagliflozin on Patients With Chronic SIADH - the SANDx Study	Effects of the SGLT2-inhibitor Empagliflozin on Patients With Chronic SIADH - the SANDx Study	SIAD - Syndrome of Inappropriate Antidiuresis;Hyponatremia	Drug: Empagliflozin 25mg;Drug: Placebo	University Hospital, Basel, Switzerland	NULL	Completed	18 Years	N/A	All	17	Phase 2/Phase 3	Switzerland
10	NCT03048747 (ClinicalTrials.gov)	March 2, 2017	7/2/2017	A Multicenter Trial to Investigate the Efficacy and Safety of Tolvaptan in Patients With Hyponatremi ...	A Multicenter, Uncontrolled, Open-label, Dose-titration Trial to Investigate the Efficacy and Safety ...	Syndrome of Inappropriate Antidiuretic Hormone Secretion	Drug: Tolvaptan Oral Tablet	Otsuka Pharmaceutical Co., Ltd.	NULL	Completed	20 Years	85 Years	All	16	Phase 3	Japan

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