81. Congenital adrenal hyperplasia Clinical trials / Disease details

Clinical trials : 87 / Drugs : 87 - (DrugBank : 23) / Drug target genes : 12 - Drug target pathways : 68

6 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03548246 (ClinicalTrials.gov)	January 2023	24/4/2015	Androgen Reduction in Congenital Adrenal Hyperplasia	A Phase 1-2 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children With Classic 21-Hydroxylase Deficiency	Congenital Adrenal Hyperplasia	Drug: Abiraterone acetate;Drug: Placebo;Drug: Hydrocortisone;Drug: Fludrocortisone	University of Texas Southwestern Medical Center	National Institutes of Health Clinical Center (CC);University of Michigan;Children's Hospital Los Angeles;Feinstein Institute for Medical Research	Withdrawn	2 Years	9 Years	All	0	Phase 2	United States
2	NCT02574910 (ClinicalTrials.gov)	August 1, 2017	24/4/2015	Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1	A Phase 1 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children With Classic 21-Hydroxylase Deficiency	Congenital Adrenal Hyperplasia	Drug: Abiraterone acetate	University of Texas Southwestern Medical Center	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);University of Michigan;Children's Hospital Los Angeles	Active, not recruiting	2 Years	9 Years	All	36	Phase 1	United States
3	NCT03760835 (ClinicalTrials.gov)	August 11, 2016	9/11/2018	Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment	Congenital Adrenal Hyperplasia: Innovative Once Daily Dual Release Hydrocortisone Treatment	Congenital Adrenal Hyperplasia	Drug: Conventional Glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone);Drug: Dual release hydrocortisone (plenadren)	Federico II University	NULL	Recruiting	18 Years	N/A	All	150	Phase 4	Italy
4	NCT01771328 (ClinicalTrials.gov)	February 2013	10/1/2013	Continuous Subcutaneous Hydrocortisone Infusion in Congenital Adrenal Hyperplasia	Continuous Subcutaneous Hydrocortisone Infusion in Congenital Adrenal Hyperplasia	Adrenal Hyperplasia, Congenital	Drug: Hydrocortisone;Drug: Cortisone acetate	Haukeland University Hospital	NULL	Recruiting	18 Years	60 Years	Both	20	Phase 2	Norway
5	NCT01495910 (ClinicalTrials.gov)	December 2011	23/11/2011	A Study Examining Doses of Abiraterone Acetate in Adult Women With 21-Hydroxylase Deficiency	An Open-Label, Multiple-Dose, Dose-Finding Study of Abiraterone Acetate in Adult Women With 21-Hydroxylase Deficiency	21-hydroxylase Deficiency	Drug: Abiraterone acetate	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	NULL	Completed	18 Years	N/A	Female	6	Phase 1	United States
6	NCT00529841 (ClinicalTrials.gov)	January 2007	12/9/2007	Research Study for Children With Salt Wasting Congenital Adrenal Hyperplasia	A Novel Therapeutic Modality for Congenital Adrenal Hyperplasia	Adrenal Hyperplasia, Congenital	Drug: Hydrocortisone sodium acetate	Baylor College of Medicine	NULL	Completed	3 Years	18 Years	Both	7	N/A	United States