DDrare: Database of Drug Development for Rare Diseases

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Alanine, aspartate and glutamate metabolism 💬	[4] ABAT, ALDH5A1, GAD1, GAD2 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
2	Aldosterone synthesis and secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
3	beta-Alanine metabolism 💬	[3] ABAT, GAD1, GAD2 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
4	Butanoate metabolism 💬	[4] ABAT, ALDH5A1, GAD1, GAD2 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
5	Calcium signaling pathway 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
6	Circadian entrainment 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
7	Cortisol synthesis and secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
8	Cushing syndrome 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
9	GABAergic synapse 💬	[3] ABAT, GAD1, GAD2 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
10	GnRH secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬

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