DDrare: Database of Drug Development for Rare Diseases

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Calcium signaling pathway 💬	[2] EDNRA, EDNRB 💬	D01227 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
2	Calcium signaling pathway 💬	[2] EDNRA, EDNRB 💬	D07538 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
3	cAMP signaling pathway 💬	[1] EDNRA 💬	D01227 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
4	cAMP signaling pathway 💬	[1] EDNRA 💬	D07538 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
5	cGMP-PKG signaling pathway 💬	[3] ADRA2A, ADRA2B, ADRA2C 💬	D00514 💬	Dexmedetomidine	[12] 2 , 4 , 6 , 21, 34, 46, 70, 113, 212, 215, 226, 280 💬
6	cGMP-PKG signaling pathway 💬	[3] ADRA2A, ADRA2B, ADRA2C 💬	D01205 💬	Dexmedetomidine	[12] 2 , 4 , 6 , 21, 34, 46, 70, 113, 212, 215, 226, 280 💬
7	cGMP-PKG signaling pathway 💬	[2] EDNRA, EDNRB 💬	D01227 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
8	cGMP-PKG signaling pathway 💬	[2] EDNRA, EDNRB 💬	D07538 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
9	cGMP-PKG signaling pathway 💬	[1] PDE5A 💬	D02229 💬	Sildenafil	[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
10	cGMP-PKG signaling pathway 💬	[1] PDE5A 💬	D08514 💬	Sildenafil	[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬

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