DDrare: Database of Drug Development for Rare Diseases

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
2	Adipocytokine signaling pathway 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
3	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB2 💬	D07713 💬	Clenbuterol	[5] 1 , 2 , 6 , 13, 256 💬
4	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB2 💬	D02147 💬	Salbutamol	[14] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
5	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬	D00358 💬	Lidocaine	[12] 6 , 13, 34, 46, 51, 70, 84, 86, 168, 226, 231, 256 💬
6	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬	D02086 💬	Lidocaine	[12] 6 , 13, 34, 46, 51, 70, 84, 86, 168, 226, 231, 256 💬
7	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬	D08127 💬	Lidocaine	[12] 6 , 13, 34, 46, 51, 70, 84, 86, 168, 226, 231, 256 💬
8	Alanine, aspartate and glutamate metabolism 💬	[4] ABAT, ALDH5A1, GAD1, GAD2 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
9	Aldosterone synthesis and secretion 💬	[3] CACNA1G, CACNA1H, CACNA1I 💬	D00399 💬	Valproic acid	[16] 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
10	Alzheimer disease 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬

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