DDrare: Database of Drug Development for Rare Diseases

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
2	Adipocytokine signaling pathway 💬	[1] JAK2 💬	D09970 💬	Tofacitinib	[12] 11, 40, 46, 49, 50, 51, 53, 84, 96, 97, 107, 271 💬
3	Adipocytokine signaling pathway 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
4	Adipocytokine signaling pathway 💬	[1] TNF 💬	D02597 💬	Adalimumab	[16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
5	Adipocytokine signaling pathway 💬	[1] TNF 💬	D04358 💬	Golimumab	[6] 46, 56, 84, 96, 97, 271 💬
6	Adipocytokine signaling pathway 💬	[1] TNF 💬	D02598 💬	Infliximab	[25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
7	Adipocytokine signaling pathway 💬	[1] TNF 💬	D01583 💬	Pirfenidone	[10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
8	Adipocytokine signaling pathway 💬	[1] TNF 💬	D00754 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
9	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬	D00358 💬	Lidocaine	[12] 6 , 13, 34, 46, 51, 70, 84, 86, 168, 226, 231, 256 💬
10	Adrenergic signaling in cardiomyocytes 💬	[1] SCN5A 💬	D02086 💬	Lidocaine	[12] 6 , 13, 34, 46, 51, 70, 84, 86, 168, 226, 231, 256 💬

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