Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
11 mg QD to 15 mg QD PF-06649751[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
21 mg QD to 7 mg QD PF-06649751 (if de-escalated in parent study)[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
315 mg QD de-escalated to 7 mg QD PF-06649751 in parent study remain at 7 mg QD[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
415 mg QD PF-06649751[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
53 mg QD to 15 mg QD PF-06649751[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
63 mg QD to 7 mg QD PF-06649751 (de-escalated in parent study)[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
77 mg QD to 15 mg QD PF-06649751[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
87 mg QD to 7 mg QD PF-06649751 (de-escalated in parent study)[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
9PF-06649751[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
10PF-06649751 - 15mg[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
11PF-06649751 - 1mg[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
12PF-06649751 - 5mg[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
13PF-06649751 high dose (15 mg QD)[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
14PF-06649751 low dose (1 mg QD)[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
15PF-06649751 middle dose 1 (3 mg QD)[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6
16PF-06649751 middle dose 2 (7 mg QD)[1] Tavapadon (Synonym: PF-06649751)[1] D11431 [2] DRD1,
DRD5 💬		[10] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, cAMP signaling pathway 💬[1] 6