Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Abacavir [4] Abacavir; Abacavir sulfate; Triumeq; Ziagen[2] D00891 ,
D07057 		--[4] 2, 135, 265, 325
2 Abatacept [2] Abatacept; ORENCIA[1] D03203 [2] CD80,
CD86 💬		[12] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬[26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
3 Abemaciclib [1] Abemaciclib[1] D10688 [2] CDK4,
CDK6 💬		[29] AGE-RAGE signaling pathway in diabetic complications, Bladder cancer, Breast cancer, Cell cycle, Cellular senescence, Chronic myeloid leukemia, Cushing syndrome, Endocrine resistance, Epstein-Barr virus infection, Glioma, Hepatitis C, Hepatocellular carcinoma, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Measles, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer, T cell receptor signaling pathway, Tight junction, Viral carcinogenesis, p53 signaling pathway 💬[1] 34
4 Abetimus [1] Abetimus---[1] 49
5 ABH001 [1] ABH001---[1] 36
6 Abiraterone [3] Abiraterone; Abiraterone Acetate; ZYTIGA---[2] 75, 81
7 Abituzumab [1] Abituzumab---[1] 51
8 Abrilumab [1] Abrilumab[1] D10540 [2] ITGA4,
ITGB7 💬		[15] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer, Yersinia infection 💬[2] 96, 97
9 ABX-1431 [1] ABX-1431---[1] 13
10 ABX-464 [0] ---[3] 46, 96, 97
11 AC-430 [0] ---[1] 46
12 Acacia [1] Gum Arabic[1] D02779 --[1] 46
13 Acalabrutinib [1] Acalabrutinib[1] D10893 [1] BTK 💬[7] B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency 💬[2] 46, 61
14 Acamprosate [1] Acamprosate[2] D02780 ,
D07058 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[2] 6, 206
15 Acarbose [1] Acarbose[1] D00216 [5] AMY2A,
AMY2B,
GAA,
GANC,
MGAM 💬		[7] Carbohydrate digestion and absorption, Galactose metabolism, Lysosome, Metabolic pathways, Pancreatic secretion, Salivary secretion, Starch and sucrose metabolism 💬[1] 298
16 Acebilustat [1] Acebilustat---[1] 299
17 Aceclofenac [1] Aceclofenac[1] D01545 [3] PTGES,
PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 46
18 Aceneuramic acid [1] ACENEURAMIC ACID[1] D11016 --[1] 30
19 Acetamide [1] Acetamide---[2] 86, 154
20 Acetaminophen [5] Acetaminophen; Oxycodone/Acetaminophen; Paracetamol; Tylenol; Ultracet[1] D00217 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[18] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
21 Acetate [1] Acetate---[43] 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299
22 Acetazolamide [1] Acetazolamide[2] D00218 ,
D01196 		[13] CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬		[7] Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬[8] 13, 86, 90, 115, 154, 155, 225, 230
23 Acetic acid [1] Acetic acid[1] D00010 --[1] 97
24 Acetic acid C-11 [1] 11C-ACETATE---[3] 13, 86, 88
25 Acetohydroxamic acid [1] Acetohydroxamic Acid[1] D00220 --[2] 6, 251
26 Acetylcarnitine [2] Acetyl-L-carnitine; Acetylcarnitine---[3] 2, 265, 298
27 Acetylcholine [1] Acetylcholine---[1] 11
28 Acetylcysteine [3] Acetylcysteine; Mucomyst; N-acetylcysteine[1] D00221 --[20] 6, 13, 19, 20, 34, 49, 51, 53, 58, 85, 90, 94, 111, 164, 193, 233, 296, 298, 299, 337
29 Acetylsalicylic acid [2] ACETYLSALICYLIC ACID; Aspirin[1] D00109 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251
30 Acipimox [1] Acipimox[1] D07190 --[2] 78, 265
31 Acitretin [1] Acitretin[1] D02754 [5] RARA,
RARB,
RXRA,
RXRB,
RXRG 💬		[19] Acute myeloid leukemia, Adipocytokine signaling pathway, Bile secretion, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Gastric cancer, Hepatitis C, Lipid and atherosclerosis, Non-alcoholic fatty liver disease, Non-small cell lung cancer, PI3K-Akt signaling pathway, PPAR signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer 💬[1] 37
32 Acotiamide [1] Acotiamide---[1] 51
33 ACR-16 [0] ---[1] 8
34 ACR325 [1] ACR325---[1] 6
35 Acteoside [1] Acteoside---[1] 66
36 Activated charcoal [1] Carbon---[9] 6, 46, 50, 51, 85, 86, 96, 97, 298
37 Acyclovir [3] Aciclovir; Acycloguanosine; Acyclovir[1] D00222 --[5] 13, 28, 46, 53, 60
38 Adalimumab [6] Adalimumab; AMGEVITA; Hulio; HUMIRA; Hyrimoz; Imraldi[1] D02597 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271
39 Adefovir [1] Adefovir[1] D02768 --[1] 46
40 Ademetionine [2] SAM-e; SAMe[1] D07128 --[2] 6, 93
41 Adenine [1] Adenin[1] D00034 --[1] 46
42 Adenosine [2] Adenosine; Ginseng[1] D00045 [4] ADORA1,
ADORA2A,
ADORA2B,
ADORA3 💬		[12] Alcoholism, Calcium signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 13, 58, 65
43 Adenosine phosphate [0] [1] D02769 [4] ADORA1,
ADORA2A,
ADORA2B,
ADORA3 💬		[12] Alcoholism, Calcium signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 46
44 Adipose-Derived Mesenchymal Stem Cells: Autologous or Allogeneic Origins [1] HB-adMSCs---[7] 2, 4, 6, 13, 46, 49, 113
45 ADL5859 [1] ADL5859---[1] 46
46 Adrabetadex [1] Adrabetadex---[1] 19
47 Afamelanotide [2] AFAMELANOTIDE; SCENESSE[1] D10511 [1] MC1R 💬[2] Melanogenesis, Neuroactive ligand-receptor interaction 💬[3] 159, 161, 254
48 Afegostat [1] Afegostat[1] D09576 --[1] 19
49 Afimetoran [1] BMS-986256[1] D11908 --[1] 49
50 Aflibercept [2] Aflibercept; Eylea[1] D09574 [3] PGF,
VEGFA,
VEGFB 💬		[24] AGE-RAGE signaling pathway in diabetic complications, Bladder cancer, Calcium signaling pathway, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, EGFR tyrosine kinase inhibitor resistance, Fluid shear stress and atherosclerosis, Focal adhesion, HIF-1 signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, VEGF signaling pathway 💬[2] 90, 166
51 Agalsidase alfa [5] AGALSIDASE ALFA; Agalsidase Alpha; Alpha-galactosidase A; Recombinant alpha-galactosidase A; REPLAGAL[1] D02784 [1] GLA 💬[6] Galactose metabolism, Glycerolipid metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series, Lysosome, Metabolic pathways, Sphingolipid metabolism 💬[1] 19
52 Agalsidase beta [2] AGALSIDASE BETA; FABRAZYME[1] D03228 [1] GLA 💬[6] Galactose metabolism, Glycerolipid metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series, Lysosome, Metabolic pathways, Sphingolipid metabolism 💬[1] 19
53 Agomelatine [1] Agomelatine[1] D02578 [3] HTR2C,
MTNR1A,
MTNR1B 💬		[6] Calcium signaling pathway, Circadian entrainment, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse 💬[1] 6
54 Ajulemic acid [1] Ajulemic acid[1] D11312 [1] CNR2 💬[1] Neuroactive ligand-receptor interaction 💬[3] 50, 51, 299
55 AK106-001616 [1] AK106-001616---[1] 46
56 AKCEA-TTR-LRx [1] Eplontersen---[1] 28
57 Alanine [2] Alanine; L-alanine[1] D00012 --[5] 6, 13, 251, 298, 299
58 Albendazole [2] Albendazole; Eskazole[1] D00134 --[12] 5, 6, 7, 13, 28, 51, 67, 86, 96, 97, 114, 127
59 Albumin human [5] Albumin; Human albumin; Human serum albumin; Optison; Serum albumin[2] D02792 ,
D05424 		--[3] 2, 78, 96
60 Aldesleukin [4] Aldesleukin; ILT-101; Proleukin; Recombinant human interleukin-2[1] D00748 [3] IL2RA,
IL2RB,
IL2RG 💬		[14] Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Inflammatory bowel disease, JAK-STAT signaling pathway, Measles, PI3K-Akt signaling pathway, Pathways in cancer, Primary immunodeficiency, Th1 and Th2 cell differentiation, Th17 cell differentiation, Transcriptional misregulation in cancer, Viral protein interaction with cytokine and cytokine receptor 💬[6] 2, 35, 49, 65, 96, 97
61 Aldosterone [1] Aldosterone[1] D10528 [1] NR3C2 💬[1] Aldosterone-regulated sodium reabsorption 💬[1] 222
62 Alefacept [1] Alefacept[1] D02800 [1] CD58 💬[2] Cell adhesion molecules, Epstein-Barr virus infection 💬[6] 37, 60, 65, 164, 284, 285
63 Alemtuzumab [4] ALEMTUZUMAB; Campath; Lemtrada; MABCAMPATH[1] D02802 [1] CD52 💬-[22] 13, 15, 19, 20, 36, 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326
64 Alendronic acid [3] Alendronate; Alendronate sodium; ALENDRONIC ACID[2] D00939 ,
D07119 		[1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[7] 19, 41, 46, 50, 271, 274, 299
65 Alfacalcidol [2] Alfacalcidol; One-alpha[1] D01518 [1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[8] 41, 46, 49, 50, 96, 107, 235, 238
66 Alfuzosin [1] Alfuzosin[2] D01692 ,
D07124 		[1] ADRA1A 💬[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 13
67 Alginic acid [3] Algin; Alginate; Alginic acid[1] D02324 --[4] 51, 53, 97, 299
68 Alglucerase [1] Ceredase[1] D02810 [1] GBA 💬[4] Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism 💬[1] 19
69 Alglucosidase alfa [4] ALGLUCOSIDASE ALFA; Alpha-glucosidase; Lumizyme; Myozyme[1] D03207 [1] GAA 💬[4] Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬[1] 256
70 Alicaforsen [1] Alicaforsen---[2] 96, 97
71 Alirocumab [2] ALIROCUMAB; Praluent[1] D10335 [1] PCSK9 💬[1] Cholesterol metabolism 💬[1] 79
72 Aliskiren [1] Aliskiren[1] D03208 [1] REN 💬[3] Diabetic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[3] 66, 167, 222
73 Alitretinoin [2] ALITRETINOIN; Toctino[1] D02815 [5] RARA,
RARB,
RXRA,
RXRB,
RXRG 💬		[19] Acute myeloid leukemia, Adipocytokine signaling pathway, Bile secretion, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Gastric cancer, Hepatitis C, Lipid and atherosclerosis, Non-alcoholic fatty liver disease, Non-small cell lung cancer, PI3K-Akt signaling pathway, PPAR signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer 💬[1] 49
74 Alkaline Phosphatase [1] Alkaline Phosphatase---[4] 46, 93, 97, 172
75 Allantoin [1] ALLANTOIN[1] D00121 --[1] 36
76 Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells [1] Orbcel-C---[2] 94, 95
77 Allopurinol [2] ALLOPURINOL; ALLOPURINOL SODIUM[1] D00224 [1] XDH 💬[5] Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Peroxisome, Purine metabolism 💬[6] 6, 46, 57, 66, 96, 97
78 Aloe vera leaf [3] Aloe; Aloe vera; Aloe vera gel---[3] 53, 97, 226
79 Alpha-1-proteinase inhibitor [6] Alpha 1-Antitrypsin; Alpha 1-Proteinase Inhibitor; ALPHA-1-ANTITRYPSIN; Alpha1-Proteinase Inhibitor; Glassia; Prolastin-C---[3] 231, 298, 299
80 alpha-Linolenic acid [1] Linolenic acid---[2] 46, 286
81 alpha-Tocopherol acetate [3] Tocopherol acetate; TOCOPHERYL ACETATE; Vitamin E---[2] 49, 206
82 Alprazolam [1] Alprazolam[1] D00225 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[2] 8, 75
83 Alprostadil [1] Alprostadil[2] D00180 ,
D02705 		[1] PTGER1 💬[4] Calcium signaling pathway, Human cytomegalovirus infection, Neuroactive ligand-receptor interaction, Pathways in cancer 💬[2] 51, 70
84 Altropane [1] Altropane---[1] 6
85 ALTU-135 [1] ALTU-135---[1] 299
86 Aluminium [2] Aluminium; Aluminum---[2] 11, 46
87 Aluminium phosphate [1] Aluminium phosphate---[1] 46
88 Aluminum hydroxide [2] Aluminium hydroxide; Aluminum hydroxide[1] D02416 --[2] 11, 46
89 Alunacedase alfa [1] Recombinant Human Angiotensin-Converting Enzyme 2---[1] 86
90 Alvelestat [1] ALVELESTAT---[1] 231
91 Amantadine [3] AMANTADINE; AMANTADINE HYDROCHLORIDE; GOCOVRI[2] D00777 ,
D07441 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[4] 6, 8, 13, 127
92 Ambrisentan [3] Ambrisentan; Letairis; Volibris[1] D07077 [1] EDNRA 💬[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[7] 51, 84, 85, 86, 88, 210, 211
93 Ambroxol [1] Ambroxol[1] D07442 --[2] 6, 19
94 AMG 108 [1] AMG 108---[1] 46
95 Amifampridine [2] Amifampridine; Firdapse[1] D10228 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[3] 3, 11, 12
96 Amifostine [1] Amifostine[1] D00226 --[1] 28
97 Amikacin [5] Amikacin; AMIKACIN SULFATE; Amikacina; Amikacine; Arikayce[2] D00865 ,
D02543 		--[2] 60, 299
98 Amiloride [3] AMILORIDE; Amiloride Hydrochloride; Midamor[2] D00649 ,
D07447 		[3] SCNN1A,
SCNN1B,
SCNN1G 💬		[2] Aldosterone-regulated sodium reabsorption, Taste transduction 💬[4] 13, 67, 225, 299
99 Amino acids [1] Amino acids---[3] 70, 240, 298
100 Aminocaproic acid [2] Aminocaproic acid; EACA[1] D00160 [1] PLG 💬[4] Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬[1] 70
101 Aminohippuric acid [1] Aminohippurate[2] D01421 ,
D06890 		--[4] 49, 53, 67, 86
102 Aminolevulinic acid [3] 5-aminolevulinic acid; Aminolevulinic acid; Gliolan[2] D02908 ,
D07567 		--[5] 34, 96, 97, 254, 286
103 Aminophylline [1] Aminophylline[2] D00227 ,
D05429 		[18] ADORA1,
ADORA2B,
PDE10A,
PDE11A,
PDE1A,
PDE1B,
PDE1C,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE7A,
PDE7B,
PDE8A,
PDE8B 💬		[23] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Cortisol synthesis and secretion, Cushing syndrome, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 63
104 Aminopterin [1] Aminopterin---[1] 46
105 Aminosalicylic acid [2] 4-Aminosalicylic acid; Aminosalicylic acid[1] D00162 --[3] 13, 96, 97
106 Amiodarone [1] Amiodarone[2] D00636 ,
D02910 		[16] ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
KCND3,
KCNJ11,
KCNJ12,
KCNJ3,
KCNJ5,
KCNJ8,
KCNQ1,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[32] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Dilated cardiomyopathy, Dopaminergic synapse, Estrogen signaling pathway, Gap junction, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, Insulin secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Pancreatic secretion, Protein digestion and absorption, Regulation of lipolysis in adipocytes, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Type II diabetes mellitus, Vascular smooth muscle contraction, Vibrio cholerae infection, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 28, 127
107 Amitriptyline [3] Amitriptylin; Amitriptyline; Amitriptyline hydrochloride[2] D00809 ,
D07448 		[2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[4] 78, 97, 226, 299
108 Amlodipine [1] AMLODIPINE[3] D00615 ,
D02914 ,
D07450 		[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 13, 51, 67, 298
109 Ammonia [1] Ammonia[1] D02916 --[3] 86, 88, 296
110 Ammonium chloride [1] Ammonium chloride[1] D01139 --[3] 96, 107, 251
111 Amniotic Epithelial Cells [1] Amniotic Epithelial Cells---[1] 26
112 Amoxapine [1] Amoxapine[1] D00228 [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[1] 46
113 Amoxicillin [4] Amoxicilina; AMOXICILLIN; Amoxycillin; Augmentin[3] D00229 ,
D02925 ,
D07452 		--[9] 6, 19, 46, 63, 84, 96, 97, 222, 299
114 Amphotericin B [2] ABELCET; Amphotericin B[1] D00203 --[1] 299
115 Ampicillin [1] ABPC[3] D00204 ,
D01251 ,
D02119 		--[5] 2, 6, 13, 84, 299
116 Ampreloxetine [1] Ampreloxetine[1] D11688 [2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 17
117 Amprenavir [1] Amprenavir[1] D00894 --[1] 265
118 Amyl Nitrite [1] Amyl Nitrite[1] D00517 [3] GUCY1A1,
GUCY1A2,
GUCY1B1 💬		[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 58
119 Anacetrapib [1] ANACETRAPIB[1] D08855 [1] CETP 💬[1] Cholesterol metabolism 💬[1] 79
120 Anakinra [2] ANAKINRA; KINERET[1] D02934 [2] IL1R1,
IL1R2 💬		[15] Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[19] 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
121 Anastrozole [2] Anastrozole; Arimidex[1] D00960 [1] CYP19A1 💬[3] Metabolic pathways, Ovarian steroidogenesis, Steroid hormone biosynthesis 💬[3] 78, 86, 193
122 Andrographolide [1] Andrographolide---[1] 97
123 Anfibatide [1] Anfibatide---[1] 64
124 Angiotensin II [2] Angiotensin; Angiotensin II[2] D00150 ,
D02014 		[2] AGTR1,
AGTR2 💬		[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[7] 17, 19, 46, 66, 86, 222, 224
125 Anifrolumab [1] ANIFROLUMAB[1] D11082 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[2] 46, 49
126 anle138b [1] Anle138b---[1] 6
127 Anrukinzumab [1] Anrukinzumab[1] D08857 [1] IL13 💬[8] Asthma, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, IL-17 signaling pathway, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Th1 and Th2 cell differentiation 💬[1] 97
128 Antihemophilic factor human [6] Alphanate; Factor VIII; HUMAN COAGULATION FACTOR VIII; Humate-P; Voncento; WILATE---[1] 288
129 Antihemophilic factor, human recombinant [4] ADVATE; Factor VIII; OCTOCOG ALFA; RAHF[1] D02958 --[1] 288
130 Antilymphocyte immunoglobulin (horse) [4] Anti-Thymocyte Globulin; Atgam; HATG; Horse anti-thymocyte globulin---[1] 60
131 Antithymocyte immunoglobulin (rabbit) [10] Anti-thymocyte globulin; ANTITHYMOCYTE IMMUNOGLOBULIN; Antithymocyte immunoglobulin (rabbit); Lapine T-Lymphocyte Immune Globulin; Rabbit anti-human thymocyte immunoglobulin; Rabbit antithymocyte globulin; Rabbit ATG; RATG; Thymoglobulin; THYMOGLOBULINE---[12] 13, 36, 49, 51, 60, 62, 65, 96, 283, 285, 286, 326
132 ANX-510 [0] ---[3] 6, 265, 288
133 Apabetalone [1] Apabetalone[1] D11131 [4] BRD2,
BRD3,
BRD4,
BRDT 💬		-[1] 86
134 Apadamtase alfa [1] Apadamtase alfa---[1] 64
135 Apigenin [1] Apigenin---[1] 97
136 Apitegromab [1] Apitegromab[1] D11797 [1] MSTN 💬[1] Cytokine-cytokine receptor interaction 💬[1] 3
137 Apixaban [2] Apixaban; Eliquis[1] D03213 [1] F10 💬[1] Complement and coagulation cascades 💬[3] 96, 97, 222
138 Aplindore [1] Aplindore---[1] 6
139 Apomorphine [3] APOKYN; Apomorfina; Apomorphine[2] D02004 ,
D07460 		[2] DRD1,
DRD2 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[3] 5, 6, 7
140 Apple [1] Apple---[1] 70
141 Apraclonidine [1] Apraclonidine[2] D01008 ,
D07461 		[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 11
142 Apratastat [1] Apratastat[1] D08859 [2] ADAM17,
MMP13 💬		[7] Alzheimer disease, Coronavirus disease - COVID-19, Epithelial cell signaling in Helicobacter pylori infection, IL-17 signaling pathway, Notch signaling pathway, Parathyroid hormone synthesis, secretion and action, Relaxin signaling pathway 💬[1] 46
143 Apremilast [2] APREMILAST; Otezla[1] D08860 [4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[7] 46, 50, 56, 97, 107, 162, 271
144 Aprotinin [1] Aprotinin[1] D02971 --[1] 28
145 AQX-1125 [1] AQX-1125---[1] 226
146 AR-42 [1] AR-42---[1] 34
147 Arabica coffee bean [1] Coffee---[2] 96, 97
148 Aramchol [1] Aramchol---[1] 265
149 Arbaclofen [2] Arbaclofen; BACLOFEN[1] D09791 [2] GABBR1,
GABBR2 💬		[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬[2] 13, 206
150 Arbaclofen Placarbil [1] Arbaclofen Placarbil[1] D08861 [2] GABBR1,
GABBR2 💬		[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬[1] 13
151 Arginine [6] Arginina; Arginine; L-Arg; L-Arginin; L-arginine; R-Gene[1] D02982 --[12] 46, 58, 65, 67, 78, 96, 97, 98, 113, 210, 251, 299
152 Arimoclomol [1] ARIMOCLOMOL[1] D11374 --[3] 2, 15, 19
153 Aripiprazole [1] Aripiprazole[1] D01164 [4] DRD2,
DRD3,
HTR1A,
HTR2A 💬		[12] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[2] 6, 206
154 Armodafinil [2] Armodafinil; Modafinil[1] D03215 [1] SLC6A3 💬[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[3] 6, 13, 84
155 Artenimol [1] Dihydroartemisinin[1] D07362 --[1] 49
156 Artesunate [1] Artesunate[1] D02482 --[8] 18, 46, 53, 66, 96, 97, 215, 271
157 Arundic acid [1] Arundic Acid[1] D06296 --[1] 2
158 ARX201 [1] ARX201---[1] 78
159 Ascorbic acid [4] Acidum ascorbicum; ASCORBIC ACID; Iron; Vitamin C[1] D00018 --[8] 10, 97, 192, 206, 210, 211, 212, 298
160 Asfotase alfa [2] ASFOTASE ALFA; Strensiq[1] D10595 [1] ALPL 💬[4] Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, Thiamine metabolism 💬[1] 172
161 Asparaginase Escherichia coli [2] Asparaginase; L-asparaginase[1] D02997 --[1] 65
162 Aspartame [0] [1] D02381 [2] TAS1R2,
TAS1R3 💬		[2] Carbohydrate digestion and absorption, Taste transduction 💬[5] 6, 13, 67, 86, 230
163 Aspergillus oryzae [1] Aspergillus oryzae---[1] 97
164 AstraZeneca COVID-19 Vaccine [3] ChAdOx1 nCoV-19; COVID-19 Vaccine AstraZeneca; Vaxzevria---[4] 46, 51, 53, 299
165 AT2220 [1] AT2220---[1] 256
166 Atacicept [2] Atacicept; TACI-Fc5[1] D09704 [2] TNFSF13,
TNFSF13B 💬		[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[4] 13, 46, 49, 66
167 Ataluren [2] ATALUREN; Translarna[1] D09323 --[6] 19, 113, 140, 246, 299, 329
168 Atazanavir [2] Atazanavir; Reyataz[2] D01276 ,
D07471 		--[1] 265
169 Atenolol [1] ATENOLOL[1] D00235 [1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 167
170 Atezolizumab [1] Atezolizumab[1] D10773 [1] CD274 💬[2] Cell adhesion molecules, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬[1] 85
171 ATL-2502 [1] ATL-2502---[1] 97
172 ATL1102 [1] ATL1102---[1] 13
173 Atomoxetine [2] Atomoxetine; Strattera[2] D02574 ,
D07473 		[1] SLC6A2 💬[1] Synaptic vesicle cycle 💬[4] 6, 8, 13, 17
174 Atorvastatin [3] ATORVASTATIN; Atorvastatin calcium; Lipitor[3] D00258 ,
D00887 ,
D07474 		[1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[18] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
175 Atosiban [1] Atosiban[1] D03008 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[1] 118
176 Atovaquone [1] ATOVAQUONE[1] D00236 --[1] 61
177 Atrasentan [1] ATRASENTAN---[3] 66, 218, 222
178 Atropine [2] Atropina; Atropine[5] D00113 ,
D01077 ,
D02069 ,
D03011 ,
D03814 		[5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 2, 299
179 ATYR1923 [1] ATYR1923---[1] 84
180 AV-101 [1] AV-101---[2] 6, 86
181 Avacincaptad pegol [1] Avacincaptad pegol---[1] 301
182 Avacopan [1] AVACOPAN[1] D11093 [1] C5AR1 💬[6] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Staphylococcus aureus infection 💬[3] 43, 44, 222
183 Avalglucosidase alfa [2] Avalglucosidase Alfa; NeoGAA[1] D11744 [1] GAA 💬[4] Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬[1] 256
184 Avatrombopag [2] Avatrombopag; Doptelet[1] D10306 [1] MPL 💬[2] Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway 💬[2] 60, 63
185 Avdoralimab [1] Avdoralimab---[1] 162
186 Avibactam [1] Avibactam---[1] 299
187 Aviptadil [1] Aviptadil[1] D12127 --[5] 49, 51, 84, 85, 86
188 Axitinib [1] Axitinib[1] D03218 [3] FLT1,
FLT4,
KDR 💬		[15] Breast cancer, Calcium signaling pathway, EGFR tyrosine kinase inhibitor resistance, Fluid shear stress and atherosclerosis, Focal adhesion, HIF-1 signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Rheumatoid arthritis, Transcriptional misregulation in cancer, VEGF signaling pathway 💬[1] 34
189 Azathioprine [3] AZATHIOPRINE; Azatioprina; Imuran[2] D00238 ,
D03033 		--[21] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162
190 AZD-0328 [0] ---[1] 6
191 AZD-1236 [0] ---[1] 299
192 AZD-4017 [0] ---[1] 75
193 AZD-5672 [0] ---[1] 46
194 AZD-7325 [0] ---[1] 206
195 AZD-9056 [0] ---[2] 46, 96
196 Azithromycin [5] AZITHROMYCIN; AZITHROMYCIN DIHYDRATE; Azithromycin monohydrate; AZITHROMYCINE; ZITHROMAX[3] D02134 ,
D06390 ,
D07486 		--[6] 13, 84, 85, 96, 228, 299
197 Aztreonam [2] Aztreonam; Cayston[2] D00240 ,
D06558 		--[2] 228, 299