Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 D-glucose [2] D-glucose; Glucose[1] D00009 --[3] 49, 86, 88
2 D-Proline [1] D-Proline---[1] 97
3 D-Serine [1] D-Serine---[1] 6
4 Dabigatran [1] Dabigatran[1] D09707 [1] F2 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Platelet activation, Regulation of actin cytoskeleton 💬[4] 51, 85, 91, 124
5 Dabigatran etexilate [1] Dabigatran etexilate[1] D07144 [1] F2 💬[8] Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Platelet activation, Regulation of actin cytoskeleton 💬[1] 51
6 Dabrafenib [1] Dabrafenib[1] D10064 [1] BRAF 💬[44] Acute myeloid leukemia, Alcoholism, Alzheimer disease, Bladder cancer, Breast cancer, Chemical carcinogenesis - reactive oxygen species, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endometrial cancer, ErbB signaling pathway, Focal adhesion, FoxO signaling pathway, Gastric cancer, Glioma, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Insulin signaling pathway, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanoma, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Progesterone-mediated oocyte maturation, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Regulation of actin cytoskeleton, Renal cell carcinoma, Serotonergic synapse, Thyroid cancer, Vascular smooth muscle contraction, cAMP signaling pathway, mTOR signaling pathway 💬[1] 34
7 Daclizumab [3] Daclizumab; Zenapax; Zinbryta[1] D03639 [1] IL2RA 💬[11] Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, JAK-STAT signaling pathway, Measles, PI3K-Akt signaling pathway, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[8] 13, 56, 60, 65, 97, 107, 283, 284
8 Dalfampridine [7] 4-Aminopyridine; 4-AP; Ampyra; Dalfampridine; FAMPRIDINA; FAMPRIDINE; Fampyra[1] D04127 [4] KCNA4,
KCNC3,
KCND2,
KCND3 💬		[4] Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬[5] 3, 4, 6, 13, 14
9 Dalteparin [2] Dalteparin; Fragmin---[1] 222
10 Danazol [1] Danazol[1] D00289 [3] AR,
ESR1,
PGR 💬		[12] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[5] 60, 63, 64, 65, 285
11 Danicopan [1] DANICOPAN[1] D11641 [1] CFD 💬[3] Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬[2] 62, 222
12 Dantrolene [2] Dantrolene; Dantrolene sodium[2] D02274 ,
D02347 		--[2] 13, 233
13 Dapagliflozin [1] Dapagliflozin[1] D08897 [1] SLC5A2 💬-[2] 49, 222
14 Dapirolizumab pegol [1] Dapirolizumab pegol---[2] 13, 49
15 Dapsone [1] Dapsone[1] D00592 --[6] 35, 42, 60, 84, 90, 162
16 Daratumumab [2] DARATUMUMAB; Darzalex[1] D10777 [1] CD38 💬[7] Calcium signaling pathway, Hematopoietic cell lineage, Metabolic pathways, Nicotinate and nicotinamide metabolism, Oxytocin signaling pathway, Pancreatic secretion, Salivary secretion 💬[5] 16, 28, 49, 63, 222
17 Darifenacin [2] Darifenacin; Emselex[2] D01699 ,
D03654 		[1] CHRM3 💬[11] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬[2] 6, 13
18 Darunavir [1] Darunavir[1] D03656 --[1] 2
19 Darvadstrocel [2] Alofisel; DARVADSTROCEL[1] D11397 --[1] 96
20 Dasatinib [1] Dasatinib[2] D03658 ,
D06414 		[8] ABL1,
EPHA2,
FYN,
KIT,
LCK,
PDGFRB,
SRC,
YES1 💬		[77] Acute myeloid leukemia, Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Cholinergic synapse, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, Glioma, GnRH signaling pathway, Hematopoietic cell lineage, Hepatitis B, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Inflammatory mediator regulation of TRP channels, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Mitophagy - animal, NF-kappa B signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Platelet activation, Primary immunodeficiency, Prion disease, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Sphingolipid signaling pathway, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬[2] 51, 85
21 Daunorubicin [1] Daunorubicin[2] D01264 ,
D07776 		[2] TOP2A,
TOP2B 💬		[1] Platinum drug resistance 💬[1] 65
22 Davunetide [1] Davunetide[1] D09401 --[3] 5, 7, 127
23 Deanol [1] Deanol[1] D07777 --[1] 6
24 Decitabine [1] Decitabine[1] D03665 [3] DNMT1,
DNMT3A,
DNMT3B 💬		[3] Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer 💬[3] 13, 60, 63
25 Deferasirox [2] Deferasirox; EXJADE[1] D03669 --[3] 254, 284, 286
26 Deferiprone [2] DEFERIPRONE; Ferriprox[1] D07416 --[6] 2, 6, 18, 120, 122, 233
27 Deferitazole [1] Deferitazole[1] D10388 --[1] 284
28 Deferoxamine [2] Deferoxamine; Desferal[2] D01186 ,
D03670 		--[3] 46, 284, 286
29 Deflazacort [1] DEFLAZACORT[1] D03671 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[2] 30, 113
30 Delorazepam [0] [1] D07784 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 6, 46, 97
31 Denosumab [3] DENOSUMAB; Prolia; XGEVA[1] D03684 [1] TNFSF11 💬[8] Breast cancer, Chemical carcinogenesis - receptor activation, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis 💬[7] 46, 50, 93, 95, 96, 274, 299
32 Denufosol [1] Denufosol---[1] 299
33 Deoxycholic acid [1] Kybella[1] D10781 --[1] 34
34 Dersalazine [1] Dersalazine---[1] 97
35 Desflurane [1] Desflurane[1] D00546 --[2] 22, 296
36 Desipramine [1] Desipramine[2] D00812 ,
D07791 		[2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 120, 156
37 Desloratadine [1] Desloratadine[1] D03693 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 13
38 Desmopressin [5] DDAVP; Desmopressin; Desmopressin acetate; Desmopressine; Minirin[2] D00291 ,
D02235 		[2] AVPR2,
F8 💬		[4] Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬[6] 6, 64, 72, 75, 225, 288
39 Desogestrel [2] Desogestrel; Désogestrel[1] D02367 [2] ESR1,
PGR 💬		[11] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬[1] 230
40 Desoxyribonuclease [1] Desoxyribonuclease---[1] 299
41 Deucravacitinib [1] Deucravacitinib[1] D11817 [1] TYK2 💬[16] Coronavirus disease - COVID-19, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis 💬[2] 96, 97
42 Deutetrabenazine [1] Deutetrabenazine[1] D10701 [1] SLC18A2 💬[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 8
43 Deutivacaftor [1] DEUTIVACAFTOR[1] D11423 [1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
44 Dexamethasone [5] Decadron; Dexametasona; Dexamethasone; DEXAMETHASONE SODIUM PHOSPHATE; Maxidex[9] D00292 ,
D00975 ,
D01510 ,
D01615 ,
D01632 ,
D01948 ,
D02174 ,
D02591 ,
D02592 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
45 Dexchlorpheniramine [1] Dexchlorpheniramine[1] D07803 [1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[2] 13, 49
46 Dexlansoprazole [1] Dexlansoprazole[1] D08903 [2] ATP4A,
ATP4B 💬		[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬[1] 98
47 Dexmedetomidine [4] Dexdor; DEXMEDETOMIDINA; Dexmedetomidine; DEXMEDETOMIDINE HYDROCHLORIDE[2] D00514 ,
D01205 		[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[13] 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
48 Dexpramipexole [1] Dexpramipexole[1] D09886 [5] DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[1] 2
49 Dexrazoxane [1] Dexrazoxane[1] D03730 [2] TOP2A,
TOP2B 💬		[1] Platinum drug resistance 💬[1] 13
50 Dextran [1] Dextran[1] D00060 --[5] 2, 62, 79, 96, 97
51 Dextromethorphan [4] Dextromethorphan; Dextromethorphan hydrobromide; Dextrometorfano; Nuedexta[3] D00848 ,
D03742 ,
D03744 		[6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
52 Dextrose, unspecified form [2] Dextrose; Glucose---[19] 2, 6, 13, 49, 50, 56, 60, 65, 70, 75, 86, 88, 96, 160, 195, 226, 254, 257, 299
53 Dezamizumab [1] Dezamizumab[1] D11471 [1] APCS 💬-[1] 28
54 Diacerein [1] Diacerein[1] D07270 --[3] 36, 46, 63
55 Diazepam [1] Diazepam[1] D00293 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[3] 46, 155, 298
56 Diazoxide [1] Diazoxide[1] D00294 [2] ABCC8,
KCNJ11 💬		[4] ABC transporters, GnRH secretion, Insulin secretion, Type II diabetes mellitus 💬[2] 13, 193
57 Dibotermin alfa [1] BMP-2[1] D03779 [1] BMPR2 💬[7] Axon guidance, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Hippo signaling pathway, MicroRNAs in cancer, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬[1] 34
58 Dichloroacetic acid [1] Dichloroacetate---[1] 86
59 Dichlorobenzene [0] ---[1] 40
60 Dichloroisoproterenol [0] ---[2] 6, 299
61 Diclofenac [3] Diclofenac; Diclofenac sodium; Diclofenac SR[3] D00903 ,
D00904 ,
D07816 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[5] 13, 34, 46, 78, 271
62 Diclofenamide [1] Dichlorphenamide[1] D00518 [13] CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬		[7] Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬[1] 114
63 Dicloxacillin [1] DICLOXACILLIN[2] D02137 ,
D02348 		--[1] 299
64 Didanosine [1] Didanosine[1] D00296 --[2] 25, 265
65 Diethyl ether [1] Ether[1] D01772 --[1] 235
66 Diflunisal [1] Diflunisal[1] D00130 [1] PTGS2 💬[22] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 28
67 Digitoxin [1] Digitoxin[1] D00297 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬		[18] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 299
68 Digoxin [1] Digoxin[1] D00298 [4] ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬		[18] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 8, 46, 210
69 Dihydrocodeine [0] [2] D01481 ,
D07831 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 310
70 Dihydroergotoxine [1] Dihydroergotoxine[1] D07839 --[1] 6
71 Dihydrotachysterol [0] [1] D00299 [1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[2] 6, 85
72 Diltiazem [2] Diltiazem; Diltiazem Hydrochloride[3] D00616 ,
D03830 ,
D07845 		[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 58, 86
73 Dimercaprol [0] [1] D00167 --[5] 49, 51, 84, 85, 299
74 Dimethyl fumarate [3] Dimethyl fumarate; Dimethylfumarat; TECFIDERA[1] D03846 [1] KEAP1 💬[6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬[5] 13, 49, 51, 86, 296
75 Dimethyl sulfoxide [2] Dimethyl sulfoxide; DMSO[1] D01043 --[1] 226
76 Dimethyltryptamine [0] ---[1] 13
77 Diosmin [1] DIOSMIN[1] D07858 --[1] 265
78 Diphenhydramine [2] Diphenhydramine; Diphenhydramine hydrochloride[6] D00300 ,
D00669 ,
D02419 ,
D03285 ,
D03360 ,
D03854 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
79 Diphenylpyraline [0] [3] D01172 ,
D01627 ,
D07862 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[1] 98
80 Dipivefrin [2] Dipivefrin; Dipivefrine[1] D02349 [9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
81 Dipraglurant [1] Dipraglurant---[1] 6
82 Dipyridamole [1] Dipyridamole[1] D00302 [2] PDE4A,
PDE5A 💬		[6] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 46, 49, 51, 66, 96, 224
83 Diquafosol [1] Diquafosol---[1] 53
84 Diroximel fumarate [1] Diroximel fumarate[1] D11154 --[1] 13
85 Dirucotide [1] Dirucotide[1] D09396 --[1] 13
86 Dithiopyr [1] DIMENSION---[1] 55
87 Ditiocarb [1] Diethyldithiocarbamate---[1] 169
88 DL-dimyristoylphosphatidylcholine [1] ABELCET---[1] 299
89 DL-dimyristoylphosphatidylglycerol [1] ABELCET---[1] 299
90 Dobutamine [2] Dobutamin; Dobutamine[4] D00632 ,
D03879 ,
D03880 ,
D03881 		[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 57, 58, 215
91 Doconexent [1] Docosahexaenoic acid---[10] 6, 46, 48, 49, 90, 94, 113, 240, 299, 301
92 Dolutegravir [2] Dolutegravir; Triumeq[1] D10066 --[2] 2, 265
93 Domagrozumab [1] PF-06252616[1] D11047 [1] MSTN 💬[1] Cytokine-cytokine receptor interaction 💬[1] 113
94 Domperidone [1] Domperidone[2] D01745 ,
D07868 		[1] DRD2 💬[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[5] 6, 13, 17, 51, 230
95 Donepezil [3] Aricept; Donepezil; Donepezil hydrochloride[2] D00670 ,
D07869 		[1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[9] 5, 6, 13, 46, 78, 124, 127, 156, 206
96 Dopamine [2] Dopamina; Dopamine[2] D00633 ,
D07870 		[5] DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[4] 6, 7, 74, 299
97 Doravirine [1] Doravirine[1] D10624 --[1] 265
98 Doripenem [2] DORIBAX; Doripenem[1] D03895 --[1] 299
99 Dornase alfa [3] Dornase alfa; Dornase alpha; Pulmozyme[1] D03896 --[2] 53, 299
100 Dorzolamide [1] Dorzolamide[2] D00653 ,
D07871 		[13] CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬		[7] Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬[1] 90
101 Dotatate [2] DOTA-TATE; Dotatate---[4] 41, 75, 84, 238
102 Dotatate gallium Ga-68 [1] 68Ga-DOTATATE---[3] 75, 84, 238
103 Doxazosin [2] CARDURA; Doxazosin[2] D00608 ,
D07874 		[3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[2] 57, 67
104 Doxepin [1] Doxepin[2] D00814 ,
D07875 		[3] HRH1,
SLC6A2,
SLC6A4 💬		[5] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 6
105 Doxorubicin [2] Doxorubicin; Doxorubicin Hydrochloride[1] D03899 [2] TOP2A,
TOP2B 💬		[1] Platinum drug resistance 💬[5] 26, 28, 34, 65, 331
106 Doxycycline [4] Doxycyclin; Doxycycline; DOXYCYCLINE HYCLATE; Doxycycline Tablets[5] D00307 ,
D02129 ,
D03903 ,
D03904 ,
D07876 		--[16] 13, 23, 28, 46, 84, 85, 89, 96, 97, 158, 161, 162, 167, 227, 280, 299
107 Drisapersen [1] Drisapersen[1] D10114 [1] DMD 💬[4] Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Viral myocarditis 💬[1] 113
108 Dronabinol [4] DELTA-9-TETRAHYDROCANNABINOL; DRONABINOL; SATIVEX; Tetrahydrocannabinol[1] D00306 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[8] 2, 8, 13, 36, 46, 96, 271, 298
109 Droxidopa [4] DOPS; Droxidopa; L-DOPS; Northera[1] D01277 [9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[5] 5, 6, 17, 169, 170
110 Dulaglutide [2] Dulaglutide; Trulicity[1] D09889 [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[2] 13, 299
111 Duloxetine [3] Cymbalta; DULOXETINE; Duloxetine hydrochloride[2] D01179 ,
D07880 		[2] SLC6A2,
SLC6A4 💬		[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 13
112 Dupilumab [2] DUPILUMAB; Dupixent[1] D10354 [1] IL4R 💬[8] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Inflammatory bowel disease, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation 💬[4] 51, 98, 160, 162
113 Durvalumab [1] Durvalumab[1] D10808 [1] CD274 💬[2] Cell adhesion molecules, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬[1] 85
114 Dutasteride [2] Dutasterida; Dutasteride[1] D03820 [2] SRD5A1,
SRD5A2 💬		[3] Metabolic pathways, Prostate cancer, Steroid hormone biosynthesis 💬[2] 1, 2
115 Duvoglustat [3] 1-deoxynojirimycin; Deoxynojirimycin; Duvoglustat[1] D09605 [1] GAA 💬[4] Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬[1] 256
116 Dydrogesterone [1] DYDROGESTERONE[1] D01217 [1] PGR 💬[5] Breast cancer, Chemical carcinogenesis - receptor activation, Estrogen signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation 💬[1] 13