Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	ADORA1	[7] cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ...	D00528	Caffeine	[9] 2, 6, 13, 21, 46, 78, 96, 97, 265
2	ADORA1	[7] cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ...	D01453	Caffeine	[9] 2, 6, 13, 21, 46, 78, 96, 97, 265
3	ADORA2A	[7] Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-re ...	D00528	Caffeine	[9] 2, 6, 13, 21, 46, 78, 96, 97, 265
4	ADORA2A	[7] Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-re ...	D01453	Caffeine	[9] 2, 6, 13, 21, 46, 78, 96, 97, 265
5	GHR	[5] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signal ...	D02691	Somatotropin	[23] 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276 ...
6	GHR	[5] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signal ...	D03297	Mecasermin	[6] 65, 78, 96, 168, 265, 299
7	GHR	[5] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signal ...	D04870	Mecasermin	[6] 65, 78, 96, 168, 265, 299
8	GHRHR	[2] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action	D06655	Tesamorelin	[2] 78, 265
9	HMGCR	[4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	D00434	Simvastatin	[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
10	HMGCR	[4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	D00887	Atorvastatin	[18] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299

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