Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	SIGMAR1	[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases	D00848	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
2	SIGMAR1	[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases	D03742	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
3	SIGMAR1	[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases	D03744	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
4	IL17F	[4] Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Th17 cell differentiation, Infl ...	D11550	Bimekizumab	[3] 46, 97, 271
5	TPH2	[4] Tryptophan metabolism, Folate biosynthesis, Metabolic pathways, Serotonergic synapse	D09973	Telotristat	[1] 97
6	CNR1	[4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endoc ...	D10915	Cannabidiol	[19] 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
7	CNR2	[1] Neuroactive ligand-receptor interaction	D10915	Cannabidiol	[11] 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
8	ADORA1	[7] cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ...	D00528	Caffeine	[9] 2, 6, 13, 21, 46, 78, 96, 97, 265
9	ADORA1	[7] cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ...	D01453	Caffeine	[9] 2, 6, 13, 21, 46, 78, 96, 97, 265
10	ADORA2A	[7] Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-re ...	D00528	Caffeine	[9] 2, 6, 13, 21, 46, 78, 96, 97, 265

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