Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 ADA [3] Purine metabolism, Metabolic pathways, Primary immunodeficiency D11017 Elapegademase [1] 65
2 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
3 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
4 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00718 Flavoxate [1] 226
5 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D01712 Theophylline [2] 236, 299
6 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D02017 Theophylline [2] 236, 299
7 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D05429 Aminophylline [1] 63
8 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
9 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06104 Theophylline [2] 236, 299
10 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
11 PDE10A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
12 CA5B [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
13 CA5B [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
14 CA5B [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
15 CA5B [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
16 CA5B [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
17 TPH2 [3] Tryptophan metabolism, Metabolic pathways, Serotonergic synapse D09973 Telotristat [1] 97
18 ADH1A [5] Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Metabolic pathways D00707 Fomepizole [1] 301
19 ADH1B [5] Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Metabolic pathways D00707 Fomepizole [1] 301
20 ADH1C [5] Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Metabolic pathways D00707 Fomepizole [1] 301
21 COMT [3] Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways D00781 Entacapone [2] 6, 17
22 COMT [3] Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways D00786 Tolcapone [3] 6, 28, 127
23 COMT [3] Steroid hormone biosynthesis, Tyrosine metabolism, Metabolic pathways D10825 Opicapone [1] 6
24 CPS1 [2] Nitrogen metabolism, Metabolic pathways D07130 Carglumic acid [3] 245, 246, 251
25 CYP11B1 [2] Steroid hormone biosynthesis, Metabolic pathways D00410 Metyrapone [2] 75, 193
26 CYP11B1 [2] Steroid hormone biosynthesis, Metabolic pathways D05019 Metyrapone [2] 75, 193
27 CYP11B2 [2] Steroid hormone biosynthesis, Metabolic pathways D11061 Osilodrostat [1] 75
28 CYP17A1 [4] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling pathway D00351 Ketoconazole [3] 8, 13, 75
29 CYP19A1 [3] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis D00960 Anastrozole [3] 78, 86, 193
30 CYP19A1 [3] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis D00964 Letrozole [2] 81, 89
31 DDC [5] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse D00558 Carbidopa [9] 2, 4, 6, 13, 17, 90, 140, 164, 201
32 DDC [5] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse D03082 Benserazide [1] 6
33 DHFR [2] One carbon pool by folate, Metabolic pathways D00142 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
34 DHFR [2] One carbon pool by folate, Metabolic pathways D02115 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
35 DHODH [2] Pyrimidine metabolism, Metabolic pathways D00749 Leflunomide [12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
36 DHODH [2] Pyrimidine metabolism, Metabolic pathways D10172 Teriflunomide [3] 13, 25, 26
37 NQO1 [3] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Pathways in cancer D00564 Warfarin [13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
38 NQO1 [3] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Pathways in cancer D01280 Warfarin [13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
39 NQO1 [3] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Pathways in cancer D08682 Warfarin [13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
40 DNMT1 [2] Metabolic pathways, MicroRNAs in cancer D03665 Decitabine [3] 13, 60, 63
41 DNMT3A [2] Metabolic pathways, MicroRNAs in cancer D03665 Decitabine [3] 13, 60, 63
42 DNMT3B [2] Metabolic pathways, MicroRNAs in cancer D03665 Decitabine [3] 13, 60, 63
43 ABAT [3] Valine, leucine and isoleucine degradation, Propanoate metabolism, Metabolic pathways D00399 Valproic acid [17] 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
44 ABAT [3] Valine, leucine and isoleucine degradation, Propanoate metabolism, Metabolic pathways D00535 Vigabatrin [2] 145, 158
45 DHFR2 [2] One carbon pool by folate, Metabolic pathways D00142 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
46 DHFR2 [2] One carbon pool by folate, Metabolic pathways D02115 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
47 ALAS1 [2] Porphyrin metabolism, Metabolic pathways D10003 Hemin [1] 254
48 ALAS1 [2] Porphyrin metabolism, Metabolic pathways D11702 Givosiran [1] 254
49 ALAS2 [2] Porphyrin metabolism, Metabolic pathways D10003 Hemin [1] 254
50 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D00939 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299
51 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D00941 Pamidronic acid [3] 270, 271, 274
52 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D00942 Risedronic acid [9] 46, 50, 66, 93, 95, 96, 107, 113, 274
53 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D01968 Zoledronic acid [13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
54 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D03234 Risedronic acid [9] 46, 50, 66, 93, 95, 96, 107, 113, 274
55 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D06378 Zoledronic acid [13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
56 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D06379 Zoledronic acid [13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
57 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D07119 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299
58 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D07281 Pamidronic acid [3] 270, 271, 274
59 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D08056 Ibandronate [3] 46, 49, 274
60 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D08484 Risedronic acid [9] 46, 50, 66, 93, 95, 96, 107, 113, 274
61 FDPS [2] Terpenoid backbone biosynthesis, Metabolic pathways D08689 Zoledronic acid [13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
62 CA14 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
63 CA14 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
64 CA14 [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
65 CA14 [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
66 CA14 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
67 ALOX5 [4] Metabolic pathways, Serotonergic synapse, Ovarian steroidogenesis, Toxoplasmosis D00414 Zileuton [3] 85, 160, 164
68 ALOX5 [4] Metabolic pathways, Serotonergic synapse, Ovarian steroidogenesis, Toxoplasmosis D01773 Oxatomide [1] 113
69 ALPL [2] Thiamine metabolism, Metabolic pathways D10595 Asfotase alfa [1] 172
70 GAA [2] Starch and sucrose metabolism, Metabolic pathways D00216 Acarbose [1] 298
71 GAA [2] Starch and sucrose metabolism, Metabolic pathways D03207 Alglucosidase alfa [1] 256
72 GAA [2] Starch and sucrose metabolism, Metabolic pathways D09605 Duvoglustat [1] 256
73 GAA [2] Starch and sucrose metabolism, Metabolic pathways D11744 Avalglucosidase alfa [1] 256
74 GAA [2] Starch and sucrose metabolism, Metabolic pathways D11798 Cipaglucosidase alfa [1] 256
75 GAD1 [3] Taurine and hypotaurine metabolism, Metabolic pathways, Type I diabetes mellitus D00399 Valproic acid [17] 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
76 GAD2 [3] Taurine and hypotaurine metabolism, Metabolic pathways, Type I diabetes mellitus D00399 Valproic acid [17] 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
77 GALNS [1] Metabolic pathways D10333 Elosulfase alfa [1] 19
78 GANC [2] Starch and sucrose metabolism, Metabolic pathways D00216 Acarbose [1] 298
79 GBA [3] Other glycan degradation, Sphingolipid metabolism, Metabolic pathways D02810 Alglucerase [1] 19
80 GBA [3] Other glycan degradation, Sphingolipid metabolism, Metabolic pathways D03020 Imiglucerase [1] 19
81 GBA [3] Other glycan degradation, Sphingolipid metabolism, Metabolic pathways D09029 Velaglucerase alfa [1] 19
82 GBA [3] Other glycan degradation, Sphingolipid metabolism, Metabolic pathways D09675 Taliglucerase alfa [1] 19
83 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
84 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
85 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D00718 Flavoxate [1] 226
86 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D01712 Theophylline [2] 236, 299
87 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D02017 Theophylline [2] 236, 299
88 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D05429 Aminophylline [1] 63
89 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
90 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D06104 Theophylline [2] 236, 299
91 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
92 PDE7B [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
93 GLA [2] Sphingolipid metabolism, Metabolic pathways D02784 Agalsidase alfa [1] 19
94 GLA [2] Sphingolipid metabolism, Metabolic pathways D03228 Agalsidase beta [1] 19
95 AMY2A [4] Starch and sucrose metabolism, Metabolic pathways, Salivary secretion, Pancreatic secretion D00216 Acarbose [1] 298
96 AMY2B [4] Starch and sucrose metabolism, Metabolic pathways, Salivary secretion, Pancreatic secretion D00216 Acarbose [1] 298
97 ANPEP [2] Metabolic pathways, Renin-angiotensin system D00087 Ubenimex [1] 86
98 GUCY1A2 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
99 GUCY1A2 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
100 GUCY1A1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
101 GUCY1A1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
102 GUCY1B1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D00517 Amyl Nitrite [1] 58
103 GUCY1B1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Platelet activation, Oxytocin signaling pathway, Renin secretion, Salivary secretion D09572 Riociguat [6] 51, 84, 86, 88, 225, 299
104 GUCY2C [2] Purine metabolism, Metabolic pathways D09355 Linaclotide [2] 6, 97
105 GUSB [3] Pentose and glucuronate interconversions, Porphyrin metabolism, Metabolic pathways D11004 Vestronidase alfa [1] 19
106 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D00359 Lovastatin [11] 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
107 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D00434 Simvastatin [21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
108 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D00887 Atorvastatin [18] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
109 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D00892 Fluvastatin [3] 79, 218, 222
110 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D00893 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333
111 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D01915 Rosuvastatin [11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
112 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D07474 Atorvastatin [18] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
113 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D07983 Fluvastatin [3] 79, 218, 222
114 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D08410 Pravastatin [9] 13, 46, 49, 67, 79, 96, 164, 265, 333
115 HMGCR [2] Terpenoid backbone biosynthesis, Metabolic pathways D08492 Rosuvastatin [11] 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
116 HMOX1 [5] Porphyrin metabolism, Metabolic pathways, Mineral absorption, Pathways in cancer, MicroRNAs in cancer D05922 Stannsoporfin [1] 254
117 HMOX2 [3] Porphyrin metabolism, Metabolic pathways, Mineral absorption D05922 Stannsoporfin [1] 254
118 HPD [4] Ubiquinone and other terpenoid-quinone biosynthesis, Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways D05177 Nitisinone [3] 6, 164, 241
119 HPRT1 [2] Purine metabolism, Metabolic pathways D00161 Mercaptopurine [4] 65, 96, 97, 164
120 HPRT1 [2] Purine metabolism, Metabolic pathways D04931 Mercaptopurine [4] 65, 96, 97, 164
121 HPRT1 [2] Purine metabolism, Metabolic pathways D06109 Tioguanine [2] 13, 37
122 HPRT1 [2] Purine metabolism, Metabolic pathways D08603 Tioguanine [2] 13, 37
123 IDS [1] Metabolic pathways D04499 Idursulfase [1] 19
124 IDS [1] Metabolic pathways D11025 Idursulfase beta [1] 19
125 IDS [1] Metabolic pathways D11812 Pabinafusp alfa [1] 19
126 IDUA [1] Metabolic pathways D04670 Laronidase [2] 19, 256
127 IMPDH1 [2] Purine metabolism, Metabolic pathways D00752 Mycophenolate mofetil [34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
128 IMPDH1 [2] Purine metabolism, Metabolic pathways D01392 Mizoribine [8] 46, 49, 51, 53, 66, 94, 222, 224
129 IMPDH1 [2] Purine metabolism, Metabolic pathways D05094 Mycophenolate mofetil [34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
130 IMPDH1 [2] Purine metabolism, Metabolic pathways D05095 Mycophenolate mofetil [34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
131 IMPDH1 [2] Purine metabolism, Metabolic pathways D05096 Mycophenolic acid [36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
132 IMPDH2 [2] Purine metabolism, Metabolic pathways D00752 Mycophenolate mofetil [34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
133 IMPDH2 [2] Purine metabolism, Metabolic pathways D01392 Mizoribine [8] 46, 49, 51, 53, 66, 94, 222, 224
134 IMPDH2 [2] Purine metabolism, Metabolic pathways D05094 Mycophenolate mofetil [34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
135 IMPDH2 [2] Purine metabolism, Metabolic pathways D05095 Mycophenolate mofetil [34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
136 IMPDH2 [2] Purine metabolism, Metabolic pathways D05096 Mycophenolic acid [36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
137 CA13 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
138 CA13 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
139 CA13 [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
140 CA13 [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
141 CA13 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
142 ARSB [1] Metabolic pathways D06565 Galsulfase [1] 19
143 MAOA [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D00505 Phenelzine [1] 6
144 MAOA [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D02561 Moclobemide [1] 6
145 MAOA [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D02579 Iproniazid [1] 6
146 MAOA [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D05458 Phentermine [1] 97
147 MAOA [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D05459 Phentermine [1] 97
148 MAOA [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D08349 Phenelzine [1] 6
149 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D00505 Phenelzine [1] 6
150 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D00785 Selegiline [1] 6
151 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D02562 Rasagiline [7] 2, 5, 6, 13, 17, 58, 66
152 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D02579 Iproniazid [1] 6
153 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D03731 Selegiline [1] 6
154 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D05458 Phentermine [1] 97
155 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D05459 Phentermine [1] 97
156 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D08349 Phenelzine [1] 6
157 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D08469 Rasagiline [7] 2, 5, 6, 13, 17, 58, 66
158 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D10158 Safinamide [2] 6, 17
159 MAOB [6] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Parkinson disease D10829 Rasagiline [7] 2, 5, 6, 13, 17, 58, 66
160 NPR1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Thermogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion D04051 Erythrityl tetranitrate [1] 46
161 NPR1 [7] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Thermogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion D05147 Nesiritide [2] 46, 58
162 NPR2 [4] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Oxytocin signaling pathway D04051 Erythrityl tetranitrate [1] 46
163 NPR2 [4] Purine metabolism, Metabolic pathways, Vascular smooth muscle contraction, Oxytocin signaling pathway D11190 Vosoritide [1] 276
164 ODC1 [1] Metabolic pathways D07883 Eflornithine [1] 65
165 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D00355 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299
166 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D00455 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
167 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D00724 Rabeprazole [2] 2, 51
168 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D01207 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
169 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D01984 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
170 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D02593 Pantoprazole [2] 13, 65
171 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D04056 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
172 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D05259 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
173 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D05261 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
174 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D05353 Pantoprazole [2] 13, 65
175 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D07917 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
176 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D08463 Rabeprazole [2] 2, 51
177 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D08903 Dexlansoprazole [1] 98
178 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D09339 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
179 ATP4A [2] Oxidative phosphorylation, Metabolic pathways D11784 Vonoprazan [2] 63, 98
180 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D00355 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299
181 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D00455 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
182 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D00724 Rabeprazole [2] 2, 51
183 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D01207 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
184 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D01984 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
185 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D02593 Pantoprazole [2] 13, 65
186 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D04056 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
187 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D05259 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
188 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D05261 Omeprazole [16] 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
189 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D05353 Pantoprazole [2] 13, 65
190 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D07917 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
191 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D08463 Rabeprazole [2] 2, 51
192 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D08903 Dexlansoprazole [1] 98
193 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D09339 Esomeprazole [8] 13, 46, 86, 98, 107, 113, 298, 299
194 ATP4B [2] Oxidative phosphorylation, Metabolic pathways D11784 Vonoprazan [2] 63, 98
195 PAH [3] Phenylalanine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Metabolic pathways D11077 Pegvaliase [1] 240
196 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
197 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
198 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00718 Flavoxate [1] 226
199 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D01712 Theophylline [2] 236, 299
200 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D02017 Theophylline [2] 236, 299
201 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D05429 Aminophylline [1] 63
202 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
203 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06104 Theophylline [2] 236, 299
204 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
205 PDE11A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
206 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00227 Aminophylline [1] 63
207 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00371 Theophylline [2] 236, 299
208 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00718 Flavoxate [1] 226
209 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D01712 Theophylline [2] 236, 299
210 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D02017 Theophylline [2] 236, 299
211 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D05429 Aminophylline [1] 63
212 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D06103 Theophylline [2] 236, 299
213 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D06104 Theophylline [2] 236, 299
214 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07546 Bucladesine [1] 246
215 PDE1A [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07961 Flavoxate [1] 226
216 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00227 Aminophylline [1] 63
217 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00371 Theophylline [2] 236, 299
218 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00718 Flavoxate [1] 226
219 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D01712 Theophylline [2] 236, 299
220 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D02017 Theophylline [2] 236, 299
221 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D05429 Aminophylline [1] 63
222 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D06103 Theophylline [2] 236, 299
223 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D06104 Theophylline [2] 236, 299
224 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07546 Bucladesine [1] 246
225 PDE1C [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07961 Flavoxate [1] 226
226 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D00227 Aminophylline [1] 63
227 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D00371 Theophylline [2] 236, 299
228 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D00528 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
229 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D00718 Flavoxate [1] 226
230 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D01453 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
231 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D01712 Theophylline [2] 236, 299
232 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D02017 Theophylline [2] 236, 299
233 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D05429 Aminophylline [1] 63
234 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D06103 Theophylline [2] 236, 299
235 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D06104 Theophylline [2] 236, 299
236 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D07546 Bucladesine [1] 246
237 PDE2A [4] Purine metabolism, Metabolic pathways, Olfactory transduction, Morphine addiction D07961 Flavoxate [1] 226
238 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D00227 Aminophylline [1] 63
239 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D00371 Theophylline [2] 236, 299
240 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D00417 Milrinone [1] 294
241 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D00528 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
242 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D00718 Flavoxate [1] 226
243 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D01385 Ibudilast [2] 2, 13
244 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D01453 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
245 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D01712 Theophylline [2] 236, 299
246 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D01896 Cilostazol [3] 51, 70, 124
247 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D02017 Theophylline [2] 236, 299
248 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D02085 Milrinone [1] 294
249 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D04720 Levosimendan [1] 2
250 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D05429 Aminophylline [1] 63
251 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D06103 Theophylline [2] 236, 299
252 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D06104 Theophylline [2] 236, 299
253 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D07546 Bucladesine [1] 246
254 PDE3A [4] Purine metabolism, Metabolic pathways, Renin secretion, Morphine addiction D07961 Flavoxate [1] 226
255 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00227 Aminophylline [1] 63
256 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00371 Theophylline [2] 236, 299
257 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00417 Milrinone [1] 294
258 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00528 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
259 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D00718 Flavoxate [1] 226
260 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D01385 Ibudilast [2] 2, 13
261 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D01453 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
262 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D01712 Theophylline [2] 236, 299
263 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D01896 Cilostazol [3] 51, 70, 124
264 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D02017 Theophylline [2] 236, 299
265 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D02085 Milrinone [1] 294
266 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D04720 Levosimendan [1] 2
267 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D05429 Aminophylline [1] 63
268 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D06103 Theophylline [2] 236, 299
269 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D06104 Theophylline [2] 236, 299
270 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D07546 Bucladesine [1] 246
271 PDE3B [6] Purine metabolism, Metabolic pathways, Progesterone-mediated oocyte maturation, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction D07961 Flavoxate [1] 226
272 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00227 Aminophylline [1] 63
273 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00302 Dipyridamole [6] 46, 49, 51, 66, 96, 224
274 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00371 Theophylline [2] 236, 299
275 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
276 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00718 Flavoxate [1] 226
277 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01385 Ibudilast [2] 2, 13
278 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
279 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01712 Theophylline [2] 236, 299
280 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01783 Rolipram [2] 8, 13
281 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D02017 Theophylline [2] 236, 299
282 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05429 Aminophylline [1] 63
283 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05744 Roflumilast [2] 84, 299
284 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06103 Theophylline [2] 236, 299
285 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06104 Theophylline [2] 236, 299
286 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07546 Bucladesine [1] 246
287 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07961 Flavoxate [1] 226
288 PDE4A [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
289 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00227 Aminophylline [1] 63
290 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00371 Theophylline [2] 236, 299
291 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
292 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00718 Flavoxate [1] 226
293 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01385 Ibudilast [2] 2, 13
294 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
295 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01712 Theophylline [2] 236, 299
296 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01783 Rolipram [2] 8, 13
297 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D02017 Theophylline [2] 236, 299
298 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05429 Aminophylline [1] 63
299 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05744 Roflumilast [2] 84, 299
300 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06103 Theophylline [2] 236, 299
301 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06104 Theophylline [2] 236, 299
302 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07546 Bucladesine [1] 246
303 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07961 Flavoxate [1] 226
304 PDE4B [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
305 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00227 Aminophylline [1] 63
306 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00371 Theophylline [2] 236, 299
307 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
308 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00718 Flavoxate [1] 226
309 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01385 Ibudilast [2] 2, 13
310 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
311 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01712 Theophylline [2] 236, 299
312 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01783 Rolipram [2] 8, 13
313 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D02017 Theophylline [2] 236, 299
314 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05429 Aminophylline [1] 63
315 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05744 Roflumilast [2] 84, 299
316 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06103 Theophylline [2] 236, 299
317 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06104 Theophylline [2] 236, 299
318 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07546 Bucladesine [1] 246
319 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07961 Flavoxate [1] 226
320 PDE4C [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
321 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00227 Aminophylline [1] 63
322 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00371 Theophylline [2] 236, 299
323 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00528 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
324 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D00718 Flavoxate [1] 226
325 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01385 Ibudilast [2] 2, 13
326 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01453 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
327 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01712 Theophylline [2] 236, 299
328 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D01783 Rolipram [2] 8, 13
329 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D02017 Theophylline [2] 236, 299
330 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05429 Aminophylline [1] 63
331 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D05744 Roflumilast [2] 84, 299
332 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06103 Theophylline [2] 236, 299
333 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D06104 Theophylline [2] 236, 299
334 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07546 Bucladesine [1] 246
335 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D07961 Flavoxate [1] 226
336 PDE4D [4] Purine metabolism, Metabolic pathways, Parathyroid hormone synthesis, secretion and action, Morphine addiction D08860 Apremilast [7] 46, 50, 56, 97, 107, 162, 271
337 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
338 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
339 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00718 Flavoxate [1] 226
340 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D01712 Theophylline [2] 236, 299
341 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D02017 Theophylline [2] 236, 299
342 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D05429 Aminophylline [1] 63
343 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
344 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06104 Theophylline [2] 236, 299
345 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
346 PDE7A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
347 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
348 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
349 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D00718 Flavoxate [1] 226
350 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D01712 Theophylline [2] 236, 299
351 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D02017 Theophylline [2] 236, 299
352 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D05429 Aminophylline [1] 63
353 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
354 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D06104 Theophylline [2] 236, 299
355 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
356 PDE8A [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
357 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00227 Aminophylline [1] 63
358 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00371 Theophylline [2] 236, 299
359 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00528 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
360 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D00718 Flavoxate [1] 226
361 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D01453 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
362 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D01712 Theophylline [2] 236, 299
363 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D02017 Theophylline [2] 236, 299
364 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D05429 Aminophylline [1] 63
365 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D06103 Theophylline [2] 236, 299
366 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D06104 Theophylline [2] 236, 299
367 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07546 Bucladesine [1] 246
368 PDE1B [6] Purine metabolism, Metabolic pathways, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction D07961 Flavoxate [1] 226
369 ENPP2 [1] Metabolic pathways D11844 Ziritaxestat [2] 51, 85
370 PIK3CA [42] Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11158 Leniolisib [2] 53, 65
371 PIK3CB [42] Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11158 Leniolisib [2] 53, 65
372 PIK3CD [42] Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11158 Leniolisib [2] 53, 65
373 PIK3CD [42] Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Neurotrophin signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11437 Parsaclisib [3] 35, 53, 61
374 HAO1 [2] Metabolic pathways, Peroxisome D11925 Lumasiran [1] 234
375 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00109 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251
376 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00118 Naproxen [4] 13, 46, 107, 271
377 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00120 Sulindac [1] 206
378 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00126 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
379 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00132 Ketoprofen [1] 46
380 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00141 Indomethacin [3] 225, 271, 298
381 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00217 Acetaminophen [18] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
382 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00330 Flurbiprofen [3] 13, 21, 46
383 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00428 Salsalate [1] 5
384 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00813 Ketorolac [2] 70, 226
385 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00903 Diclofenac [5] 13, 34, 46, 78, 271
386 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D00904 Diclofenac [5] 13, 34, 46, 78, 271
387 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01122 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
388 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01183 Tolfenamic acid [1] 5
389 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01475 Flurbiprofen [3] 13, 21, 46
390 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01545 Aceclofenac [1] 46
391 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D01565 Indomethacin [3] 225, 271, 298
392 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D02110 Indomethacin [3] 225, 271, 298
393 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D02290 Flurbiprofen [3] 13, 21, 46
394 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D04490 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
395 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D06606 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
396 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D07816 Diclofenac [5] 13, 34, 46, 78, 271
397 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D08104 Ketorolac [2] 70, 226
398 PTGS1 [4] Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes D08149 Loxoprofen [2] 46, 271
399 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00109 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251
400 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00118 Naproxen [4] 13, 46, 107, 271
401 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00120 Sulindac [1] 206
402 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00126 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
403 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00130 Diflunisal [1] 28
404 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00132 Ketoprofen [1] 46
405 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00141 Indomethacin [3] 225, 271, 298
406 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00217 Acetaminophen [18] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
407 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00315 Etodolac [1] 46
408 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00330 Flurbiprofen [3] 13, 21, 46
409 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00428 Salsalate [1] 5
410 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00567 Celecoxib [10] 2, 3, 34, 46, 70, 89, 107, 161, 171, 271
411 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00568 Rofecoxib [1] 46
412 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00813 Ketorolac [2] 70, 226
413 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00903 Diclofenac [5] 13, 34, 46, 78, 271
414 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00904 Diclofenac [5] 13, 34, 46, 78, 271
415 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D00969 Meloxicam [4] 46, 49, 271, 296
416 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D01049 Nimesulide [1] 46
417 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D01122 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
418 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D01183 Tolfenamic acid [1] 5
419 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D01475 Flurbiprofen [3] 13, 21, 46
420 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D01545 Aceclofenac [1] 46
421 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D01565 Indomethacin [3] 225, 271, 298
422 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D02110 Indomethacin [3] 225, 271, 298
423 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D02290 Flurbiprofen [3] 13, 21, 46
424 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D02709 Valdecoxib [1] 46
425 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D03710 Etoricoxib [2] 46, 271
426 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D03714 Lumiracoxib [1] 46
427 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D03716 Parecoxib [2] 46, 271
428 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D04490 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
429 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D06606 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299
430 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D07816 Diclofenac [5] 13, 34, 46, 78, 271
431 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D08104 Ketorolac [2] 70, 226
432 PTGS2 [13] Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, MicroRNAs in cancer, Small cell lung cancer D08149 Loxoprofen [2] 46, 271
433 RRM1 [3] Purine metabolism, Pyrimidine metabolism, Metabolic pathways D01370 Cladribine [3] 11, 13, 94
434 RRM1 [3] Purine metabolism, Pyrimidine metabolism, Metabolic pathways D01907 Fludarabine [19] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
435 RRM1 [3] Purine metabolism, Pyrimidine metabolism, Metabolic pathways D03546 Clofarabine [9] 19, 20, 40, 46, 49, 60, 96, 234, 326
436 RRM1 [3] Purine metabolism, Pyrimidine metabolism, Metabolic pathways D07966 Fludarabine [19] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
437 RRM2 [4] Purine metabolism, Pyrimidine metabolism, Metabolic pathways, p53 signaling pathway D00341 Hydroxyurea [8] 3, 13, 19, 20, 65, 85, 86, 284
438 SMPD1 [4] Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, Necroptosis D10820 Olipudase alfa [1] 19
439 SRD5A1 [2] Steroid hormone biosynthesis, Metabolic pathways D03820 Dutasteride [2] 1, 2
440 SRD5A2 [3] Steroid hormone biosynthesis, Metabolic pathways, Prostate cancer D00321 Finasteride [1] 6
441 SRD5A2 [3] Steroid hormone biosynthesis, Metabolic pathways, Prostate cancer D03820 Dutasteride [2] 1, 2
442 TPH1 [3] Tryptophan metabolism, Metabolic pathways, Serotonergic synapse D09973 Telotristat [1] 97
443 TPO [3] Tyrosine metabolism, Metabolic pathways, Thyroid hormone synthesis D00401 Methimazole [1] 50
444 TYMS [3] Pyrimidine metabolism, One carbon pool by folate, Metabolic pathways D01223 Capecitabine [1] 94
445 TYMS [3] Pyrimidine metabolism, One carbon pool by folate, Metabolic pathways D01244 Tegafur [1] 46
446 UGCG [2] Sphingolipid metabolism, Metabolic pathways D05032 Miglustat [3] 19, 256, 299
447 UGCG [2] Sphingolipid metabolism, Metabolic pathways D09893 Eliglustat [1] 19
448 UGCG [2] Sphingolipid metabolism, Metabolic pathways D11439 Lucerastat [1] 19
449 UGCG [2] Sphingolipid metabolism, Metabolic pathways D11633 Venglustat [3] 6, 19, 67
450 XDH [3] Purine metabolism, Metabolic pathways, Peroxisome D00224 Allopurinol [6] 6, 46, 57, 66, 96, 97
451 XDH [3] Purine metabolism, Metabolic pathways, Peroxisome D01206 Febuxostat [3] 2, 6, 13
452 CA1 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
453 CA1 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
454 CA1 [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
455 CA1 [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
456 CA1 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
457 CA2 [4] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Pancreatic secretion D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
458 CA2 [4] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Pancreatic secretion D00518 Diclofenamide [1] 114
459 CA2 [4] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Pancreatic secretion D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
460 CA2 [4] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Pancreatic secretion D00653 Dorzolamide [1] 90
461 CA2 [4] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Pancreatic secretion D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
462 CA2 [4] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Pancreatic secretion D07871 Dorzolamide [1] 90
463 CA3 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
464 CA3 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
465 CA3 [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
466 CA3 [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
467 CA3 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
468 CA4 [3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
469 CA4 [3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation D00518 Diclofenamide [1] 114
470 CA4 [3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
471 CA4 [3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation D00653 Dorzolamide [1] 90
472 CA4 [3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
473 CA4 [3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation D07871 Dorzolamide [1] 90
474 CA5A [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
475 CA5A [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
476 CA5A [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
477 CA5A [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
478 CA5A [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
479 CA6 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
480 CA6 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
481 CA6 [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
482 CA6 [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
483 CA6 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
484 CA7 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
485 CA7 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
486 CA7 [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
487 CA7 [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
488 CA7 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
489 CA8 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
490 CA8 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
491 CA8 [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
492 CA8 [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
493 CA8 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
494 CA9 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
495 CA9 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
496 CA9 [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
497 CA9 [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
498 CA9 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
499 CA12 [2] Nitrogen metabolism, Metabolic pathways D00218 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
500 CA12 [2] Nitrogen metabolism, Metabolic pathways D00518 Diclofenamide [1] 114
501 CA12 [2] Nitrogen metabolism, Metabolic pathways D00653 Dorzolamide [1] 90
502 CA12 [2] Nitrogen metabolism, Metabolic pathways D01196 Acetazolamide [8] 13, 86, 90, 115, 154, 155, 225, 230
503 CA12 [2] Nitrogen metabolism, Metabolic pathways D07871 Dorzolamide [1] 90
504 VKORC1 [2] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways D00564 Warfarin [13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
505 VKORC1 [2] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways D01280 Warfarin [13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
506 VKORC1 [2] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways D08354 Phenindione [1] 65
507 VKORC1 [2] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways D08682 Warfarin [13] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
508 ALDH5A1 [1] Metabolic pathways D00399 Valproic acid [17] 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
509 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D00227 Aminophylline [1] 63
510 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D00371 Theophylline [2] 236, 299
511 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D00718 Flavoxate [1] 226
512 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D01712 Theophylline [2] 236, 299
513 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D02017 Theophylline [2] 236, 299
514 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D05429 Aminophylline [1] 63
515 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D06103 Theophylline [2] 236, 299
516 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D06104 Theophylline [2] 236, 299
517 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D07546 Bucladesine [1] 246
518 PDE8B [3] Purine metabolism, Metabolic pathways, Morphine addiction D07961 Flavoxate [1] 226
519 AOC3 [3] Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways D08044 Hydralazine [1] 67
520 PDE5A [2] Purine metabolism, Metabolic pathways D00302 Dipyridamole [6] 46, 49, 51, 66, 96, 224
521 PDE5A [2] Purine metabolism, Metabolic pathways D00528 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
522 PDE5A [2] Purine metabolism, Metabolic pathways D01453 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
523 PDE5A [2] Purine metabolism, Metabolic pathways D02008 Tadalafil [7] 6, 51, 75, 84, 86, 113, 210
524 PDE5A [2] Purine metabolism, Metabolic pathways D02229 Sildenafil [17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
525 PDE5A [2] Purine metabolism, Metabolic pathways D02731 Vardenafil [3] 13, 86, 299
526 PDE5A [2] Purine metabolism, Metabolic pathways D03260 Vardenafil [3] 13, 86, 299
527 PDE5A [2] Purine metabolism, Metabolic pathways D08514 Sildenafil [17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
528 PDE5A [2] Purine metabolism, Metabolic pathways D08668 Vardenafil [3] 13, 86, 299
529 PDE5A [2] Purine metabolism, Metabolic pathways D10027 Udenafil [2] 86, 210
530 MGAM [2] Starch and sucrose metabolism, Metabolic pathways D00216 Acarbose [1] 298
531 CD38 [5] Nicotinate and nicotinamide metabolism, Metabolic pathways, Oxytocin signaling pathway, Salivary secretion, Pancreatic secretion D10777 Daratumumab [5] 16, 28, 49, 63, 222
532 CD38 [5] Nicotinate and nicotinamide metabolism, Metabolic pathways, Oxytocin signaling pathway, Salivary secretion, Pancreatic secretion D11050 Isatuximab [2] 28, 61
533 CD38 [5] Nicotinate and nicotinamide metabolism, Metabolic pathways, Oxytocin signaling pathway, Salivary secretion, Pancreatic secretion D11945 Mezagitamab [1] 66
534 PTGES [1] Metabolic pathways D01545 Aceclofenac [1] 46