Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	JAK1	[27] EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway, Necroptosis, Osteoclast ...	D09959	Ruxolitinib	[1] 228
2	JAK1	[27] EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway, Necroptosis, Osteoclast ...	D09970	Tofacitinib	[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
3	JAK1	[27] EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway, Necroptosis, Osteoclast ...	D10308	Baricitinib	[13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
4	JAK1	[27] EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway, Necroptosis, Osteoclast ...	D10653	Peficitinib	[1] 46
5	JAK1	[27] EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway, Necroptosis, Osteoclast ...	D10871	Filgotinib	[6] 46, 53, 96, 97, 222, 271
6	JAK1	[27] EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway, Necroptosis, Osteoclast ...	D10944	Itacitinib	[5] 46, 51, 60, 97, 228
7	JAK1	[27] EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway, Necroptosis, Osteoclast ...	D10994	Upadacitinib	[8] 40, 41, 46, 49, 96, 97, 107, 271

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