Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 KCNA4 [2] Cortisol synthesis and secretion, Cushing syndrome D04127 Dalfampridine [5] 3, 4, 6, 13, 14
2 KCNA4 [2] Cortisol synthesis and secretion, Cushing syndrome D10228 Amifampridine [3] 3, 11, 12
3 KCNC3 [1] Spinocerebellar ataxia D04127 Dalfampridine [5] 3, 4, 6, 13, 14
4 KCNC3 [1] Spinocerebellar ataxia D10228 Amifampridine [3] 3, 11, 12
5 KCND2 [1] Serotonergic synapse D04127 Dalfampridine [5] 3, 4, 6, 13, 14
6 KCND2 [1] Serotonergic synapse D10228 Amifampridine [3] 3, 11, 12
7 KCND3 [1] Spinocerebellar ataxia D00636 Amiodarone [2] 28, 127
8 KCND3 [1] Spinocerebellar ataxia D02910 Amiodarone [2] 28, 127
9 KCND3 [1] Spinocerebellar ataxia D04127 Dalfampridine [5] 3, 4, 6, 13, 14
10 KCND3 [1] Spinocerebellar ataxia D10228 Amifampridine [3] 3, 11, 12
11 KCNJ3 [10] Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, GnRH secretion, Morphine addiction D00636 Amiodarone [2] 28, 127
12 KCNJ3 [10] Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, GnRH secretion, Morphine addiction D02910 Amiodarone [2] 28, 127
13 KCNJ5 [9] Circadian entrainment, Retrograde endocannabinoid signaling, Serotonergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, Aldosterone synthesis and secretion, GnRH secretion, Morphine addiction D00636 Amiodarone [2] 28, 127
14 KCNJ5 [9] Circadian entrainment, Retrograde endocannabinoid signaling, Serotonergic synapse, Dopaminergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, Aldosterone synthesis and secretion, GnRH secretion, Morphine addiction D02910 Amiodarone [2] 28, 127
15 KCNJ8 [1] cGMP-PKG signaling pathway D00636 Amiodarone [2] 28, 127
16 KCNJ8 [1] cGMP-PKG signaling pathway D02910 Amiodarone [2] 28, 127
17 KCNJ11 [3] Insulin secretion, GnRH secretion, Type II diabetes mellitus D00294 Diazoxide [2] 13, 193
18 KCNJ11 [3] Insulin secretion, GnRH secretion, Type II diabetes mellitus D00418 Minoxidil [1] 179
19 KCNJ11 [3] Insulin secretion, GnRH secretion, Type II diabetes mellitus D00594 Repaglinide [3] 6, 21, 299
20 KCNJ11 [3] Insulin secretion, GnRH secretion, Type II diabetes mellitus D00636 Amiodarone [2] 28, 127
21 KCNJ11 [3] Insulin secretion, GnRH secretion, Type II diabetes mellitus D02910 Amiodarone [2] 28, 127
22 KCNJ12 [2] Cholinergic synapse, Oxytocin signaling pathway D00636 Amiodarone [2] 28, 127
23 KCNJ12 [2] Cholinergic synapse, Oxytocin signaling pathway D02910 Amiodarone [2] 28, 127
24 KCNQ1 [6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D00636 Amiodarone [2] 28, 127
25 KCNQ1 [6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D02910 Amiodarone [2] 28, 127
26 KCNQ1 [6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D09569 Ezogabine [2] 2, 144
27 KCNQ2 [1] Cholinergic synapse D09569 Ezogabine [2] 2, 144
28 KCNQ3 [1] Cholinergic synapse D09569 Ezogabine [2] 2, 144
29 KDR [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D03218 Axitinib [1] 34
30 KDR [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D06272 Sorafenib [2] 34, 86
31 KDR [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D06402 Sunitinib [2] 28, 34
32 KDR [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D08524 Sorafenib [2] 34, 86
33 KDR [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D08552 Sunitinib [2] 28, 34
34 KDR [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D08881 Cediranib [1] 34
35 KDR [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D10062 Cabozantinib [1] 34
36 KDR [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D10481 Nintedanib [5] 51, 85, 89, 227, 228
37 KDR [10] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Proteoglycans in cancer, Fluid shear stress and atherosclerosis D11772 Tesevatinib [1] 67
38 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D01441 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
39 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D03658 Dasatinib [2] 51, 85
40 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D06272 Sorafenib [2] 34, 86
41 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D06402 Sunitinib [2] 28, 34
42 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D06414 Dasatinib [2] 51, 85
43 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
44 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D08524 Sorafenib [2] 34, 86
45 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D08552 Sunitinib [2] 28, 34
46 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D08953 Nilotinib [5] 6, 8, 34, 51, 86
47 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D10229 Masitinib [6] 2, 5, 6, 13, 46, 96
48 KIT [11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer D11270 Pexidartinib [1] 34
49 KLKB1 [1] Complement and coagulation cascades D10845 Conestat alfa [1] 61
50 KCNQ5 [1] Cholinergic synapse D09569 Ezogabine [2] 2, 144
51 KCNQ4 [1] Cholinergic synapse D09569 Ezogabine [2] 2, 144
52 KEAP1 [6] Ubiquitin mediated proteolysis, Parkinson disease, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis D03846 Dimethyl fumarate [5] 13, 49, 51, 86, 296