Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 SIGMAR1 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases D00848 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
2 SIGMAR1 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases D03742 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
3 SIGMAR1 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases D03744 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
4 SIGMAR1 [2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases D11383 Blarcamesine [1] 156
5 SLC22A12 - D01056 Benzbromarone [1] 86
6 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10001 Fingolimod [3] 13, 14, 156
7 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10930 Etrasimod [3] 96, 97, 98
8 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10968 Ozanimod [3] 13, 96, 97
9 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D11215 Ponesimod [1] 13
10 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D11283 Cenerimod [1] 49
11 S1PR1 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D11460 Siponimod [2] 13, 50
12 S1PR3 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10930 Etrasimod [3] 96, 97, 98
13 S1PR3 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10968 Ozanimod [3] 13, 96, 97
14 SV2C [1] ECM-receptor interaction D11842 Padsevonil [1] 149
15 SIGLEC8 - D11906 Lirentelimab [1] 98
16 SERPIND1 [1] Complement and coagulation cascades D08547 Sulodexide [4] 13, 51, 271, 288
17 SMAD7 [2] TGF-beta signaling pathway, Hippo signaling pathway D10956 Mongersen [2] 96, 97
18 SERPINC1 [1] Complement and coagulation cascades D03674 Enoxaparin [1] 46
19 SERPINC1 [1] Complement and coagulation cascades D07510 Heparin [12] 47, 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317
20 SERPINC1 [1] Complement and coagulation cascades D07510 Enoxaparin [1] 46
21 SERPINC1 [1] Complement and coagulation cascades D07510 Parnaparin [1] 97
22 SERPINC1 [1] Complement and coagulation cascades D08547 Sulodexide [4] 13, 51, 271, 288
23 SOST [2] Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action D10156 Romosozumab [1] 274
24 S1PR5 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10930 Etrasimod [3] 96, 97, 98
25 S1PR5 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10968 Ozanimod [3] 13, 96, 97
26 S1PR5 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D11460 Siponimod [2] 13, 50
27 SLAMF7 - D09337 Elotuzumab [2] 28, 300
28 SCN1A [1] Dopaminergic synapse D00252 Carbamazepine [2] 13, 231
29 SCN1A [1] Dopaminergic synapse D00354 Lamotrigine [5] 13, 34, 38, 114, 144
30 SCN1A [1] Dopaminergic synapse D00358 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
31 SCN1A [1] Dopaminergic synapse D00512 Phenytoin [1] 13
32 SCN1A [1] Dopaminergic synapse D00533 Oxcarbazepine [1] 13
33 SCN1A [1] Dopaminergic synapse D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
34 SCN1A [1] Dopaminergic synapse D00538 Zonisamide [1] 6
35 SCN1A [1] Dopaminergic synapse D00636 Amiodarone [2] 28, 127
36 SCN1A [1] Dopaminergic synapse D00638 Flecainide [1] 6
37 SCN1A [1] Dopaminergic synapse D00639 Mexiletine [5] 1, 2, 10, 113, 114
38 SCN1A [1] Dopaminergic synapse D00642 Quinidine [3] 2, 8, 13
39 SCN1A [1] Dopaminergic synapse D00643 Quinidine [3] 2, 8, 13
40 SCN1A [1] Dopaminergic synapse D01287 Levobupivacaine [1] 46
41 SCN1A [1] Dopaminergic synapse D01450 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
42 SCN1A [1] Dopaminergic synapse D01768 Oxybuprocaine [1] 6
43 SCN1A [1] Dopaminergic synapse D02086 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
44 SCN1A [1] Dopaminergic synapse D02103 Phenytoin [1] 13
45 SCN1A [1] Dopaminergic synapse D02272 Quinidine [3] 2, 8, 13
46 SCN1A [1] Dopaminergic synapse D02910 Amiodarone [2] 28, 127
47 SCN1A [1] Dopaminergic synapse D03492 Cibenzoline [1] 58
48 SCN1A [1] Dopaminergic synapse D04048 Ropivacaine [3] 36, 46, 70
49 SCN1A [1] Dopaminergic synapse D05775 Rufinamide [1] 144
50 SCN1A [1] Dopaminergic synapse D07552 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
51 SCN1A [1] Dopaminergic synapse D07962 Flecainide [1] 6
52 SCN1A [1] Dopaminergic synapse D08116 Levobupivacaine [1] 46
53 SCN1A [1] Dopaminergic synapse D08127 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
54 SCN1A [1] Dopaminergic synapse D08215 Mexiletine [5] 1, 2, 10, 113, 114
55 SCN1A [1] Dopaminergic synapse D08319 Oxybuprocaine [1] 6
56 SCN1A [1] Dopaminergic synapse D08458 Quinidine [3] 2, 8, 13
57 SCN1A [1] Dopaminergic synapse D08490 Ropivacaine [3] 36, 46, 70
58 SCN1A [1] Dopaminergic synapse D11155 Eleclazine [1] 58
59 SCN2A [1] Taste transduction D00252 Carbamazepine [2] 13, 231
60 SCN2A [1] Taste transduction D00354 Lamotrigine [5] 13, 34, 38, 114, 144
61 SCN2A [1] Taste transduction D00358 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
62 SCN2A [1] Taste transduction D00512 Phenytoin [1] 13
63 SCN2A [1] Taste transduction D00533 Oxcarbazepine [1] 13
64 SCN2A [1] Taste transduction D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
65 SCN2A [1] Taste transduction D00538 Zonisamide [1] 6
66 SCN2A [1] Taste transduction D00636 Amiodarone [2] 28, 127
67 SCN2A [1] Taste transduction D00638 Flecainide [1] 6
68 SCN2A [1] Taste transduction D00639 Mexiletine [5] 1, 2, 10, 113, 114
69 SCN2A [1] Taste transduction D00642 Quinidine [3] 2, 8, 13
70 SCN2A [1] Taste transduction D00643 Quinidine [3] 2, 8, 13
71 SCN2A [1] Taste transduction D01287 Levobupivacaine [1] 46
72 SCN2A [1] Taste transduction D01450 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
73 SCN2A [1] Taste transduction D01768 Oxybuprocaine [1] 6
74 SCN2A [1] Taste transduction D02086 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
75 SCN2A [1] Taste transduction D02103 Phenytoin [1] 13
76 SCN2A [1] Taste transduction D02272 Quinidine [3] 2, 8, 13
77 SCN2A [1] Taste transduction D02910 Amiodarone [2] 28, 127
78 SCN2A [1] Taste transduction D03492 Cibenzoline [1] 58
79 SCN2A [1] Taste transduction D04048 Ropivacaine [3] 36, 46, 70
80 SCN2A [1] Taste transduction D05775 Rufinamide [1] 144
81 SCN2A [1] Taste transduction D07552 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
82 SCN2A [1] Taste transduction D07962 Flecainide [1] 6
83 SCN2A [1] Taste transduction D08116 Levobupivacaine [1] 46
84 SCN2A [1] Taste transduction D08127 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
85 SCN2A [1] Taste transduction D08215 Mexiletine [5] 1, 2, 10, 113, 114
86 SCN2A [1] Taste transduction D08319 Oxybuprocaine [1] 6
87 SCN2A [1] Taste transduction D08458 Quinidine [3] 2, 8, 13
88 SCN2A [1] Taste transduction D08490 Ropivacaine [3] 36, 46, 70
89 SCN2A [1] Taste transduction D11155 Eleclazine [1] 58
90 SCN3A [1] Taste transduction D00252 Carbamazepine [2] 13, 231
91 SCN3A [1] Taste transduction D00354 Lamotrigine [5] 13, 34, 38, 114, 144
92 SCN3A [1] Taste transduction D00358 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
93 SCN3A [1] Taste transduction D00512 Phenytoin [1] 13
94 SCN3A [1] Taste transduction D00533 Oxcarbazepine [1] 13
95 SCN3A [1] Taste transduction D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
96 SCN3A [1] Taste transduction D00538 Zonisamide [1] 6
97 SCN3A [1] Taste transduction D00636 Amiodarone [2] 28, 127
98 SCN3A [1] Taste transduction D00638 Flecainide [1] 6
99 SCN3A [1] Taste transduction D00639 Mexiletine [5] 1, 2, 10, 113, 114
100 SCN3A [1] Taste transduction D00642 Quinidine [3] 2, 8, 13
101 SCN3A [1] Taste transduction D00643 Quinidine [3] 2, 8, 13
102 SCN3A [1] Taste transduction D01287 Levobupivacaine [1] 46
103 SCN3A [1] Taste transduction D01450 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
104 SCN3A [1] Taste transduction D01768 Oxybuprocaine [1] 6
105 SCN3A [1] Taste transduction D02086 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
106 SCN3A [1] Taste transduction D02103 Phenytoin [1] 13
107 SCN3A [1] Taste transduction D02272 Quinidine [3] 2, 8, 13
108 SCN3A [1] Taste transduction D02910 Amiodarone [2] 28, 127
109 SCN3A [1] Taste transduction D03492 Cibenzoline [1] 58
110 SCN3A [1] Taste transduction D04048 Ropivacaine [3] 36, 46, 70
111 SCN3A [1] Taste transduction D05775 Rufinamide [1] 144
112 SCN3A [1] Taste transduction D07299 Lacosamide [3] 2, 46, 149
113 SCN3A [1] Taste transduction D07552 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
114 SCN3A [1] Taste transduction D07962 Flecainide [1] 6
115 SCN3A [1] Taste transduction D08116 Levobupivacaine [1] 46
116 SCN3A [1] Taste transduction D08127 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
117 SCN3A [1] Taste transduction D08215 Mexiletine [5] 1, 2, 10, 113, 114
118 SCN3A [1] Taste transduction D08319 Oxybuprocaine [1] 6
119 SCN3A [1] Taste transduction D08458 Quinidine [3] 2, 8, 13
120 SCN3A [1] Taste transduction D08490 Ropivacaine [3] 36, 46, 70
121 SCN3A [1] Taste transduction D11155 Eleclazine [1] 58
122 SCN5A [1] Adrenergic signaling in cardiomyocytes D00252 Carbamazepine [2] 13, 231
123 SCN5A [1] Adrenergic signaling in cardiomyocytes D00354 Lamotrigine [5] 13, 34, 38, 114, 144
124 SCN5A [1] Adrenergic signaling in cardiomyocytes D00358 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
125 SCN5A [1] Adrenergic signaling in cardiomyocytes D00512 Phenytoin [1] 13
126 SCN5A [1] Adrenergic signaling in cardiomyocytes D00533 Oxcarbazepine [1] 13
127 SCN5A [1] Adrenergic signaling in cardiomyocytes D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
128 SCN5A [1] Adrenergic signaling in cardiomyocytes D00538 Zonisamide [1] 6
129 SCN5A [1] Adrenergic signaling in cardiomyocytes D00636 Amiodarone [2] 28, 127
130 SCN5A [1] Adrenergic signaling in cardiomyocytes D00638 Flecainide [1] 6
131 SCN5A [1] Adrenergic signaling in cardiomyocytes D00639 Mexiletine [5] 1, 2, 10, 113, 114
132 SCN5A [1] Adrenergic signaling in cardiomyocytes D00642 Quinidine [3] 2, 8, 13
133 SCN5A [1] Adrenergic signaling in cardiomyocytes D00643 Quinidine [3] 2, 8, 13
134 SCN5A [1] Adrenergic signaling in cardiomyocytes D01287 Levobupivacaine [1] 46
135 SCN5A [1] Adrenergic signaling in cardiomyocytes D01450 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
136 SCN5A [1] Adrenergic signaling in cardiomyocytes D01768 Oxybuprocaine [1] 6
137 SCN5A [1] Adrenergic signaling in cardiomyocytes D02086 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
138 SCN5A [1] Adrenergic signaling in cardiomyocytes D02103 Phenytoin [1] 13
139 SCN5A [1] Adrenergic signaling in cardiomyocytes D02272 Quinidine [3] 2, 8, 13
140 SCN5A [1] Adrenergic signaling in cardiomyocytes D02910 Amiodarone [2] 28, 127
141 SCN5A [1] Adrenergic signaling in cardiomyocytes D03492 Cibenzoline [1] 58
142 SCN5A [1] Adrenergic signaling in cardiomyocytes D04048 Ropivacaine [3] 36, 46, 70
143 SCN5A [1] Adrenergic signaling in cardiomyocytes D05775 Rufinamide [1] 144
144 SCN5A [1] Adrenergic signaling in cardiomyocytes D07552 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
145 SCN5A [1] Adrenergic signaling in cardiomyocytes D07962 Flecainide [1] 6
146 SCN5A [1] Adrenergic signaling in cardiomyocytes D08116 Levobupivacaine [1] 46
147 SCN5A [1] Adrenergic signaling in cardiomyocytes D08127 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
148 SCN5A [1] Adrenergic signaling in cardiomyocytes D08215 Mexiletine [5] 1, 2, 10, 113, 114
149 SCN5A [1] Adrenergic signaling in cardiomyocytes D08319 Oxybuprocaine [1] 6
150 SCN5A [1] Adrenergic signaling in cardiomyocytes D08458 Quinidine [3] 2, 8, 13
151 SCN5A [1] Adrenergic signaling in cardiomyocytes D08490 Ropivacaine [3] 36, 46, 70
152 SCN5A [1] Adrenergic signaling in cardiomyocytes D11155 Eleclazine [1] 58
153 SCN9A [1] Taste transduction D00252 Carbamazepine [2] 13, 231
154 SCN9A [1] Taste transduction D00354 Lamotrigine [5] 13, 34, 38, 114, 144
155 SCN9A [1] Taste transduction D00358 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
156 SCN9A [1] Taste transduction D00512 Phenytoin [1] 13
157 SCN9A [1] Taste transduction D00533 Oxcarbazepine [1] 13
158 SCN9A [1] Taste transduction D00537 Topiramate [6] 6, 97, 140, 144, 156, 193
159 SCN9A [1] Taste transduction D00538 Zonisamide [1] 6
160 SCN9A [1] Taste transduction D00636 Amiodarone [2] 28, 127
161 SCN9A [1] Taste transduction D00638 Flecainide [1] 6
162 SCN9A [1] Taste transduction D00639 Mexiletine [5] 1, 2, 10, 113, 114
163 SCN9A [1] Taste transduction D00642 Quinidine [3] 2, 8, 13
164 SCN9A [1] Taste transduction D00643 Quinidine [3] 2, 8, 13
165 SCN9A [1] Taste transduction D01287 Levobupivacaine [1] 46
166 SCN9A [1] Taste transduction D01450 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
167 SCN9A [1] Taste transduction D01768 Oxybuprocaine [1] 6
168 SCN9A [1] Taste transduction D02086 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
169 SCN9A [1] Taste transduction D02103 Phenytoin [1] 13
170 SCN9A [1] Taste transduction D02272 Quinidine [3] 2, 8, 13
171 SCN9A [1] Taste transduction D02910 Amiodarone [2] 28, 127
172 SCN9A [1] Taste transduction D03492 Cibenzoline [1] 58
173 SCN9A [1] Taste transduction D04048 Ropivacaine [3] 36, 46, 70
174 SCN9A [1] Taste transduction D05775 Rufinamide [1] 144
175 SCN9A [1] Taste transduction D07299 Lacosamide [3] 2, 46, 149
176 SCN9A [1] Taste transduction D07552 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298
177 SCN9A [1] Taste transduction D07962 Flecainide [1] 6
178 SCN9A [1] Taste transduction D08116 Levobupivacaine [1] 46
179 SCN9A [1] Taste transduction D08127 Lidocaine [13] 6, 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256
180 SCN9A [1] Taste transduction D08215 Mexiletine [5] 1, 2, 10, 113, 114
181 SCN9A [1] Taste transduction D08319 Oxybuprocaine [1] 6
182 SCN9A [1] Taste transduction D08458 Quinidine [3] 2, 8, 13
183 SCN9A [1] Taste transduction D08490 Ropivacaine [3] 36, 46, 70
184 SCN9A [1] Taste transduction D11155 Eleclazine [1] 58
185 SCNN1A [2] Taste transduction, Aldosterone-regulated sodium reabsorption D00649 Amiloride [4] 13, 67, 225, 299
186 SCNN1A [2] Taste transduction, Aldosterone-regulated sodium reabsorption D07447 Amiloride [4] 13, 67, 225, 299
187 SCNN1B [2] Taste transduction, Aldosterone-regulated sodium reabsorption D00649 Amiloride [4] 13, 67, 225, 299
188 SCNN1B [2] Taste transduction, Aldosterone-regulated sodium reabsorption D07447 Amiloride [4] 13, 67, 225, 299
189 SCNN1G [2] Taste transduction, Aldosterone-regulated sodium reabsorption D00649 Amiloride [4] 13, 67, 225, 299
190 SCNN1G [2] Taste transduction, Aldosterone-regulated sodium reabsorption D07447 Amiloride [4] 13, 67, 225, 299
191 SLC5A2 - D08897 Dapagliflozin [2] 49, 222
192 SLC5A2 - D10459 Empagliflozin [5] 65, 72, 96, 97, 257
193 SLC6A1 [2] Synaptic vesicle cycle, GABAergic synapse D00332 Gabapentin [5] 6, 13, 19, 70, 298
194 SLC6A2 [1] Synaptic vesicle cycle D00228 Amoxapine [1] 46
195 SLC6A2 [1] Synaptic vesicle cycle D00809 Amitriptyline [4] 78, 97, 226, 299
196 SLC6A2 [1] Synaptic vesicle cycle D00812 Desipramine [2] 120, 156
197 SLC6A2 [1] Synaptic vesicle cycle D00814 Doxepin [1] 6
198 SLC6A2 [1] Synaptic vesicle cycle D00816 Nortriptyline [2] 6, 226
199 SLC6A2 [1] Synaptic vesicle cycle D00817 Bupropion [5] 8, 18, 21, 96, 171
200 SLC6A2 [1] Synaptic vesicle cycle D00821 Venlafaxine [3] 6, 13, 46
201 SLC6A2 [1] Synaptic vesicle cycle D01179 Duloxetine [2] 6, 13
202 SLC6A2 [1] Synaptic vesicle cycle D01296 Methylphenidate [7] 6, 13, 34, 84, 113, 179, 206
203 SLC6A2 [1] Synaptic vesicle cycle D02574 Atomoxetine [4] 6, 8, 13, 17
204 SLC6A2 [1] Synaptic vesicle cycle D04999 Methylphenidate [7] 6, 13, 34, 84, 113, 179, 206
205 SLC6A2 [1] Synaptic vesicle cycle D05458 Phentermine [1] 97
206 SLC6A2 [1] Synaptic vesicle cycle D05459 Phentermine [1] 97
207 SLC6A2 [1] Synaptic vesicle cycle D07448 Amitriptyline [4] 78, 97, 226, 299
208 SLC6A2 [1] Synaptic vesicle cycle D07473 Atomoxetine [4] 6, 8, 13, 17
209 SLC6A2 [1] Synaptic vesicle cycle D07591 Bupropion [5] 8, 18, 21, 96, 171
210 SLC6A2 [1] Synaptic vesicle cycle D07791 Desipramine [2] 120, 156
211 SLC6A2 [1] Synaptic vesicle cycle D07875 Doxepin [1] 6
212 SLC6A2 [1] Synaptic vesicle cycle D07880 Duloxetine [2] 6, 13
213 SLC6A2 [1] Synaptic vesicle cycle D07938 Bupropion [5] 8, 18, 21, 96, 171
214 SLC6A2 [1] Synaptic vesicle cycle D08130 Lisdexamfetamine [1] 13
215 SLC6A2 [1] Synaptic vesicle cycle D08222 Milnacipran [2] 46, 49
216 SLC6A2 [1] Synaptic vesicle cycle D08288 Nortriptyline [2] 6, 226
217 SLC6A2 [1] Synaptic vesicle cycle D08670 Venlafaxine [3] 6, 13, 46
218 SLC6A2 [1] Synaptic vesicle cycle D11688 Ampreloxetine [2] 6, 17
219 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D00817 Bupropion [5] 8, 18, 21, 96, 171
220 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D01296 Methylphenidate [7] 6, 13, 34, 84, 113, 179, 206
221 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D03215 Armodafinil [3] 6, 13, 84
222 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D04999 Methylphenidate [7] 6, 13, 34, 84, 113, 179, 206
223 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D05458 Phentermine [1] 97
224 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D05459 Phentermine [1] 97
225 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D07591 Bupropion [5] 8, 18, 21, 96, 171
226 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D07938 Bupropion [5] 8, 18, 21, 96, 171
227 SLC6A3 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism D08130 Lisdexamfetamine [1] 13
228 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00228 Amoxapine [1] 46
229 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00326 Fluoxetine [6] 13, 17, 78, 86, 179, 206
230 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00809 Amitriptyline [4] 78, 97, 226, 299
231 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00812 Desipramine [2] 120, 156
232 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00814 Doxepin [1] 6
233 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00816 Nortriptyline [2] 6, 226
234 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00820 Trazodone [1] 2
235 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00821 Venlafaxine [3] 6, 13, 46
236 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00822 Citalopram [7] 6, 8, 13, 18, 46, 98, 127
237 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00823 Fluoxetine [6] 13, 17, 78, 86, 179, 206
238 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D00825 Sertraline [2] 6, 206
239 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D01179 Duloxetine [2] 6, 13
240 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D02260 Paroxetine [4] 6, 13, 46, 85
241 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D02360 Sertraline [2] 6, 206
242 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D02362 Paroxetine [4] 6, 13, 46, 85
243 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D02567 Escitalopram [3] 2, 6, 13
244 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D05374 Paroxetine [4] 6, 13, 46, 85
245 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D05375 Paroxetine [4] 6, 13, 46, 85
246 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D05458 Phentermine [1] 97
247 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D05459 Phentermine [1] 97
248 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07448 Amitriptyline [4] 78, 97, 226, 299
249 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07704 Citalopram [7] 6, 8, 13, 18, 46, 98, 127
250 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07704 Escitalopram [3] 2, 6, 13
251 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07791 Desipramine [2] 120, 156
252 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07875 Doxepin [1] 6
253 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07880 Duloxetine [2] 6, 13
254 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07913 Escitalopram [3] 2, 6, 13
255 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D07945 Fenfluramine [4] 140, 144, 145, 149
256 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D08222 Milnacipran [2] 46, 49
257 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D08288 Nortriptyline [2] 6, 226
258 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D08626 Trazodone [1] 2
259 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D08670 Venlafaxine [3] 6, 13, 46
260 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D10184 Vortioxetine [1] 6
261 SLC6A4 [2] Synaptic vesicle cycle, Serotonergic synapse D11688 Ampreloxetine [2] 6, 17
262 SLC10A1 [2] Bile secretion, Hepatitis B D10951 Maralixibat [3] 296, 297, 338
263 SLC10A2 [1] Bile secretion D10796 Elobixibat [1] 6
264 SLC10A2 [1] Bile secretion D10951 Maralixibat [3] 296, 297, 338
265 SLC10A2 [1] Bile secretion D11716 Odevixibat [3] 296, 297, 338
266 SLC12A2 [3] Salivary secretion, Pancreatic secretion, Vibrio cholerae infection D00247 Bumetanide [2] 6, 158
267 SLC12A2 [3] Salivary secretion, Pancreatic secretion, Vibrio cholerae infection D00331 Furosemide [1] 6
268 SLC12A3 - D00340 Hydrochlorothiazide [4] 13, 67, 225, 235
269 SLC12A3 - D00345 Indapamide [1] 13
270 SLC12A3 - D00519 Chlorothiazide [1] 225
271 SLC12A3 - D00650 Bendroflumethiazide [1] 67
272 SLC12A3 - D03471 Chlorothiazide [1] 225
273 SLC12A3 - D06401 Indapamide [1] 13
274 SLC18A2 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism D08575 Tetrabenazine [1] 8
275 SLC18A2 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism D10675 Valbenazine [1] 8
276 SLC18A2 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism D10701 Deutetrabenazine [1] 8
277 SMN1 - D11559 Onasemnogene abeparvovec [1] 3
278 SMN2 - D10881 Nusinersen [1] 3
279 SMN2 [1] Nucleocytoplasmic transport D11406 Risdiplam [1] 3
280 SMO [5] Hedgehog signaling pathway, Axon guidance, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma D09992 Vismodegib [1] 85
281 SMO [5] Hedgehog signaling pathway, Axon guidance, Pathways in cancer, Proteoglycans in cancer, Basal cell carcinoma D10671 Taladegib [1] 85
282 SMPD1 [5] Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, Lysosome, Necroptosis D10820 Olipudase alfa [1] 19
283 SNAP25 [2] Synaptic vesicle cycle, Insulin secretion D00783 Botulinum toxin type A [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226
284 SNAP25 [2] Synaptic vesicle cycle, Insulin secretion D02735 Botulinum toxin type B [4] 2, 6, 13, 51
285 SNCA [3] Alzheimer disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases D11420 Prasinezumab [1] 6
286 SOD1 [8] Peroxisome, Longevity regulating pathway - multiple species, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - reactive oxygen species D11811 Tofersen [1] 2
287 SRC [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D03252 Bosutinib [2] 2, 67
288 SRC [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D03658 Dasatinib [2] 51, 85
289 SRC [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D06414 Dasatinib [2] 51, 85
290 SRC [42] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, Mitophagy - animal, Endocytosis, Axon guidance, VEGF signaling pathway, Focal adhesion, Adherens junction, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Bacterial invasion of epithelial cells, Epithelial cell signaling in Helicobacter pylori infection, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Bladder cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D09664 Saracatinib [3] 6, 89, 272
291 SRD5A1 [2] Steroid hormone biosynthesis, Metabolic pathways D03820 Dutasteride [2] 1, 2
292 SRD5A2 [3] Steroid hormone biosynthesis, Metabolic pathways, Prostate cancer D00321 Finasteride [1] 6
293 SRD5A2 [3] Steroid hormone biosynthesis, Metabolic pathways, Prostate cancer D03820 Dutasteride [2] 1, 2
294 SSTR1 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D07431 Somatostatin [2] 67, 78
295 SSTR1 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D10147 Pasireotide [3] 67, 74, 75
296 SSTR2 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D00442 Octreotide [7] 67, 75, 84, 85, 89, 193, 227
297 SSTR2 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D06495 Octreotide [7] 67, 75, 84, 85, 89, 193, 227
298 SSTR2 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D07431 Somatostatin [2] 67, 78
299 SSTR2 [4] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion D10147 Pasireotide [3] 67, 74, 75
300 SSTR3 [2] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D07431 Somatostatin [2] 67, 78
301 SSTR3 [2] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D10147 Pasireotide [3] 67, 74, 75
302 SSTR4 [1] Neuroactive ligand-receptor interaction D07431 Somatostatin [2] 67, 78
303 SSTR5 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D07431 Somatostatin [2] 67, 78
304 SSTR5 [3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action D10147 Pasireotide [3] 67, 74, 75
305 SYK [17] NF-kappa B signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Osteoclast differentiation, Platelet activation, Neutrophil extracellular trap formation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Viral carcinogenesis D09347 Fostamatinib [4] 46, 49, 61, 66
306 S1PR4 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10930 Etrasimod [3] 96, 97, 98
307 S1PR4 [3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10968 Ozanimod [3] 13, 96, 97
308 S1PR2 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10930 Etrasimod [3] 96, 97, 98
309 S1PR2 [2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction D10968 Ozanimod [3] 13, 96, 97
310 SV2B [1] ECM-receptor interaction D11842 Padsevonil [1] 149
311 SV2A [1] ECM-receptor interaction D00709 Levetiracetam [5] 2, 4, 6, 13, 307
312 SV2A [1] ECM-receptor interaction D08879 Brivaracetam [2] 149, 309
313 SV2A [1] ECM-receptor interaction D11842 Padsevonil [1] 149