Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] RARA 💬	D00348 💬	Isotretinoin	[4] 36, 39, 159, 160 💬
2	Autoimmune thyroid disease 💬	[1] CTLA4 💬	D04603 💬	Ipilimumab	[1] 159 💬
3	Cell adhesion molecules 💬	[1] CTLA4 💬	D04603 💬	Ipilimumab	[1] 159 💬
4	Cell adhesion molecules 💬	[1] PDCD1 💬	D10316 💬	Nivolumab	[12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
5	Estrogen signaling pathway 💬	[1] RARA 💬	D00348 💬	Isotretinoin	[4] 36, 39, 159, 160 💬
6	Gastric cancer 💬	[1] RARB 💬	D00348 💬	Isotretinoin	[4] 36, 39, 159, 160 💬
7	Melanogenesis 💬	[1] MC1R 💬	D10511 💬	Afamelanotide	[3] 159, 161, 254 💬
8	Neuroactive ligand-receptor interaction 💬	[1] MC1R 💬	D10511 💬	Afamelanotide	[3] 159, 161, 254 💬
9	Non-small cell lung cancer 💬	[1] RARB 💬	D00348 💬	Isotretinoin	[4] 36, 39, 159, 160 💬
10	Pathways in cancer 💬	[2] RARA, RARB 💬	D00348 💬	Isotretinoin	[4] 36, 39, 159, 160 💬

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