Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adrenergic signaling in cardiomyocytes 💬	[5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬	D01277 💬	Droxidopa	[5] 5 , 6 , 17, 169, 170 💬
2	AMPK signaling pathway 💬	[1] ADRA1A 💬	D01277 💬	Droxidopa	[5] 5 , 6 , 17, 169, 170 💬
3	Calcium signaling pathway 💬	[6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 💬	D01277 💬	Droxidopa	[5] 5 , 6 , 17, 169, 170 💬
4	cAMP signaling pathway 💬	[2] ADRB1, ADRB2 💬	D01277 💬	Droxidopa	[5] 5 , 6 , 17, 169, 170 💬
5	cGMP-PKG signaling pathway 💬	[9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬	D01277 💬	Droxidopa	[5] 5 , 6 , 17, 169, 170 💬
6	Chemical carcinogenesis - receptor activation 💬	[3] ADRB1, ADRB2, ADRB3 💬	D01277 💬	Droxidopa	[5] 5 , 6 , 17, 169, 170 💬
7	Dilated cardiomyopathy 💬	[1] ADRB1 💬	D01277 💬	Droxidopa	[5] 5 , 6 , 17, 169, 170 💬
8	Gap junction 💬	[1] ADRB1 💬	D01277 💬	Droxidopa	[5] 5 , 6 , 17, 169, 170 💬
9	Neuroactive ligand-receptor interaction 💬	[9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬	D01277 💬	Droxidopa	[5] 5 , 6 , 17, 169, 170 💬
10	Regulation of lipolysis in adipocytes 💬	[3] ADRB1, ADRB2, ADRB3 💬	D01277 💬	Droxidopa	[5] 5 , 6 , 17, 169, 170 💬

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