Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adipocytokine signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[24] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 2 ...
2	Adipocytokine signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[24] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 2 ...
3	Alcoholic liver disease 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[24] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 2 ...
4	Alcoholic liver disease 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[24] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 2 ...
5	Aldosterone-regulated sodium reabsorption 💬	[1] NR3C2 💬	D00443 💬	Spironolactone	[7] 58, 67, 86, 113, 210, 218, 225 💬
6	Aldosterone-regulated sodium reabsorption 💬	[3] SCNN1A, SCNN1B, SCNN1G 💬	D00649 💬	Amiloride	[4] 13, 67, 225, 299 💬
7	Aldosterone-regulated sodium reabsorption 💬	[3] SCNN1A, SCNN1B, SCNN1G 💬	D07447 💬	Amiloride	[4] 13, 67, 225, 299 💬
8	Alzheimer disease 💬	[1] PTGS2 💬	D00141 💬	Indomethacin	[3] 225, 271, 298 💬
9	Alzheimer disease 💬	[1] PTGS2 💬	D01565 💬	Indomethacin	[3] 225, 271, 298 💬
10	Alzheimer disease 💬	[1] PTGS2 💬	D02110 💬	Indomethacin	[3] 225, 271, 298 💬

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