Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Calcium signaling pathway 💬	[2] EDNRA, EDNRB 💬	D01227 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
2	Calcium signaling pathway 💬	[2] EDNRA, EDNRB 💬	D07538 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
3	cAMP signaling pathway 💬	[1] EDNRA 💬	D01227 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
4	cAMP signaling pathway 💬	[1] EDNRA 💬	D07538 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
5	cGMP-PKG signaling pathway 💬	[2] EDNRA, EDNRB 💬	D01227 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
6	cGMP-PKG signaling pathway 💬	[2] EDNRA, EDNRB 💬	D07538 💬	Bosentan	[11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
7	Complement and coagulation cascades 💬	[1] SERPINC1 💬	D07510 💬	Heparin	[12] 47, 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 💬
8	Cytokine-cytokine receptor interaction 💬	[1] CSF3R 💬	D03235 💬	Filgrastim	[34] 2 , 6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 6 ...
9	Cytokine-cytokine receptor interaction 💬	[1] EPOR 💬	D03231 💬	Erythropoietin	[10] 2 , 6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
10	Hematopoietic cell lineage 💬	[1] CSF3R 💬	D03235 💬	Filgrastim	[34] 2 , 6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 6 ...

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