Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRA1A 💬 D01692 💬 Alfuzosin [1] 13 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRA1A 💬 D07124 💬 Alfuzosin [1] 13 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRA1A 💬 D01965 💬 Silodosin [2]  6 , 13 💬
4 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00608 💬 Doxazosin [2] 57, 67 💬
5 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D07874 💬 Doxazosin [2] 57, 67 💬
6 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D02268 💬 Ergoloid mesylate [2]  6 , 206 💬
7 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08064 💬 Ifenprodil [1] 85 💬
8 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00680 💬 Methylergometrine [3] 118, 280, 288 💬
9 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08207 💬 Methylergometrine [3] 118, 280, 288 💬
10 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D01307 💬 Midodrine [3]  6 , 17, 58 💬
11 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08220 💬 Midodrine [3]  6 , 17, 58 💬
12 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00454 💬 Olanzapine [2]  2 ,  8  💬
13 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D06623 💬 Olanzapine [2]  2 ,  8  💬
14 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00511 💬 Phenylephrine [1] 22 💬
15 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08365 💬 Phenylephrine [1] 22 💬
16 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00610 💬 Terazosin [1]  6  💬
17 Adrenergic signaling in cardiomyocytes 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08569 💬 Terazosin [1]  6  💬
18 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00255 💬 Carvedilol [5]  6 , 57, 86, 113, 210 💬
19 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D03415 💬 Carvedilol [5]  6 , 57, 86, 113, 210 💬
20 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D02349 💬 Dipivefrin [1]  6  💬
21 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D01277 💬 Droxidopa [5]  5 ,  6 , 17, 169, 170 💬
22 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00124 💬 Ephedrine [1] 11 💬
23 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00095 💬 Epinephrine [3] 46, 70, 96 💬
24 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00996 💬 Epinephrine [3] 46, 70, 96 💬
25 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D02149 💬 Epinephrine [3] 46, 70, 96 💬
26 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00076 💬 Norepinephrine [1] 22 💬
27 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D05206 💬 Norepinephrine [1] 22 💬
28 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D00485 💬 Pseudoephedrine [1] 17 💬
29 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D05648 💬 Pseudoephedrine [1] 17 💬
30 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D05649 💬 Pseudoephedrine [1] 17 💬
31 Adrenergic signaling in cardiomyocytes 💬
 [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 D08449 💬 Pseudoephedrine [1] 17 💬
32 Adrenergic signaling in cardiomyocytes 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNQ1, SCN5A 💬 D00636 💬 Amiodarone [2] 28, 127 💬
33 Adrenergic signaling in cardiomyocytes 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRB1, KCNQ1, SCN5A 💬 D02910 💬 Amiodarone [2] 28, 127 💬
34 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D00235 💬 Atenolol [1] 167 💬
35 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D00634 💬 Bisoprolol [3] 67, 86, 113 💬
36 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D02342 💬 Bisoprolol [3] 67, 86, 113 💬
37 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D07660 💬 Celiprolol [1] 168 💬
38 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D00632 💬 Dobutamine [3] 57, 58, 215 💬
39 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D03879 💬 Dobutamine [3] 57, 58, 215 💬
40 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D03880 💬 Dobutamine [3] 57, 58, 215 💬
41 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D03881 💬 Dobutamine [3] 57, 58, 215 💬
42 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D00644 💬 Esmolol [1] 58 💬
43 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D07916 💬 Esmolol [1] 58 💬
44 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D00601 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
45 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D02358 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
46 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D05011 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
47 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 D05127 💬 Nebivolol [4] 17, 85, 113, 167 💬
48 Adrenergic signaling in cardiomyocytes 💬
 [2] ADRB1, ADRB2 💬 D00432 💬 Nadolol [1]  6  💬
49 Adrenergic signaling in cardiomyocytes 💬
 [2] ADRB1, ADRB2 💬 D00483 💬 Propranolol [7]  6 , 158, 167, 215, 227, 278, 296 💬
50 Adrenergic signaling in cardiomyocytes 💬
 [2] ADRB1, ADRB2 💬 D08443 💬 Propranolol [7]  6 , 158, 167, 215, 227, 278, 296 💬
51 Adrenergic signaling in cardiomyocytes 💬
 [2] ADRB1, ADRB2 💬 D00378 💬 Timolol [2] 157, 227 💬
52 Adrenergic signaling in cardiomyocytes 💬
 [2] ADRB1, ADRB2 💬 D00603 💬 Timolol [2] 157, 227 💬
53 Adrenergic signaling in cardiomyocytes 💬
 [2] ADRB1, ADRB2 💬 D08600 💬 Timolol [2] 157, 227 💬
54 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D07713 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬
55 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D01373 💬 Formoterol [3] 85, 228, 299 💬
56 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D05277 💬 Formoterol [3] 85, 228, 299 💬
57 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D07990 💬 Formoterol [3] 85, 228, 299 💬
58 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D08092 💬 Isoxsuprine [1] 13 💬
59 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D08124 💬 Levosalbutamol [1] 49 💬
60 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D02147 💬 Salbutamol [14]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
61 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D00687 💬 Salmeterol [1] 299 💬
62 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D05792 💬 Salmeterol [1] 299 💬
63 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D00688 💬 Terbutaline [1] 118 💬
64 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D08570 💬 Terbutaline [1] 118 💬
65 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 D02151 💬 Tulobuterol [1]  6  💬
66 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00522 💬 Candesartan [2] 58, 67 💬
67 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00522 💬 Candesartan cilexetil [1] 67 💬
68 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00626 💬 Candesartan cilexetil [1] 67 💬
69 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
70 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
71 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
72 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D11776 💬 Sparsentan [3] 66, 218, 222 💬
73 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00627 💬 Telmisartan [2] 66, 67 💬
74 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
75 Adrenergic signaling in cardiomyocytes 💬
 [2] AGTR1, AGTR2 💬 D00150 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
76 Adrenergic signaling in cardiomyocytes 💬
 [2] AGTR1, AGTR2 💬 D02014 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
77 Adrenergic signaling in cardiomyocytes 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00297 💬 Digitoxin [1] 299 💬
78 Adrenergic signaling in cardiomyocytes 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00298 💬 Digoxin [3]  8 , 46, 210 💬
79 Adrenergic signaling in cardiomyocytes 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
80 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine [4] 13, 51, 67, 298 💬
81 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine [4] 13, 51, 67, 298 💬
82 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
83 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine [1] 67 💬
84 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem [3] 51, 58, 86 💬
85 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem [3] 51, 58, 86 💬
86 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
87 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine [1]  6  💬
88 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine [2] 70, 86 💬
89 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine [2] 70, 86 💬
90 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine [2] 50, 81 💬
91 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine [1] 90 💬
92 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline [2] 58, 272 💬
93 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline [2] 58, 272 💬
94 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine [1] 226 💬
95 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil [3] 96, 140, 167 💬
96 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil [3] 96, 140, 167 💬
97 Adrenergic signaling in cardiomyocytes 💬
 [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
98 Adrenergic signaling in cardiomyocytes 💬
 [2] CACNA2D1, CACNA2D2 💬 D11203 💬 Mirogabalin [1] 70 💬
99 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 D00332 💬 Gabapentin [5]  6 , 13, 19, 70, 298 💬
100 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 D02716 💬 Pregabalin [5] 13, 36, 46, 70, 298 💬
101 Adrenergic signaling in cardiomyocytes 💬
 [1] KCNQ1 💬 D09569 💬 Ezogabine [2]  2 , 144 💬
102 Adrenergic signaling in cardiomyocytes 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
103 Adrenergic signaling in cardiomyocytes 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
104 Adrenergic signaling in cardiomyocytes 💬
 [1] MYH7 💬 D12265 💬 Mavacamten [1] 58 💬
105 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D01450 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
106 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D07552 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
107 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00252 💬 Carbamazepine [2] 13, 231 💬
108 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D03492 💬 Cibenzoline [1] 58 💬
109 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D11155 💬 Eleclazine [1] 58 💬
110 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00638 💬 Flecainide [1]  6  💬
111 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D07962 💬 Flecainide [1]  6  💬
112 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00354 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
113 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D01287 💬 Levobupivacaine [1] 46 💬
114 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D08116 💬 Levobupivacaine [1] 46 💬
115 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00358 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
116 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D02086 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
117 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D08127 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
118 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00639 💬 Mexiletine [5]  1 ,  2 , 10, 113, 114 💬
119 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D08215 💬 Mexiletine [5]  1 ,  2 , 10, 113, 114 💬
120 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00533 💬 Oxcarbazepine [1] 13 💬
121 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D01768 💬 Oxybuprocaine [1]  6  💬
122 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D08319 💬 Oxybuprocaine [1]  6  💬
123 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00512 💬 Phenytoin [1] 13 💬
124 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D02103 💬 Phenytoin [1] 13 💬
125 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00642 💬 Quinidine [3]  2 ,  8 , 13 💬
126 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00643 💬 Quinidine [3]  2 ,  8 , 13 💬
127 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D02272 💬 Quinidine [3]  2 ,  8 , 13 💬
128 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D08458 💬 Quinidine [3]  2 ,  8 , 13 💬
129 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D04048 💬 Ropivacaine [3] 36, 46, 70 💬
130 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D08490 💬 Ropivacaine [3] 36, 46, 70 💬
131 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D05775 💬 Rufinamide [1] 144 💬
132 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00538 💬 Zonisamide [1]  6  💬