Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 D00528 💬 Caffeine [9]  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
2 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 D01453 💬 Caffeine [9]  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
3 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 D04641 💬 Istradefylline [1]  6  💬
4 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 D09717 💬 Preladenant [1]  6  💬
5 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 D05711 💬 Regadenoson [1] 58 💬
6 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 D02017 💬 Theophylline [2] 236, 299 💬
7 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 D10174 💬 Tozadenant [1]  6  💬
8 Vascular smooth muscle contraction 💬
 [2] ADORA2A, ADORA2B 💬 D00045 💬 Adenosine [3] 13, 58, 65 💬
9 Vascular smooth muscle contraction 💬
 [2] ADORA2A, ADORA2B 💬 D02769 💬 Adenosine phosphate [1] 46 💬
10 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D00227 💬 Aminophylline [1] 63 💬
11 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D05429 💬 Aminophylline [1] 63 💬
12 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D00371 💬 Theophylline [2] 236, 299 💬
13 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D01712 💬 Theophylline [2] 236, 299 💬
14 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D06103 💬 Theophylline [2] 236, 299 💬
15 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D06104 💬 Theophylline [2] 236, 299 💬
16 Vascular smooth muscle contraction 💬
 [1] ADRA1A 💬 D01692 💬 Alfuzosin [1] 13 💬
17 Vascular smooth muscle contraction 💬
 [1] ADRA1A 💬 D07124 💬 Alfuzosin [1] 13 💬
18 Vascular smooth muscle contraction 💬
 [1] ADRA1A 💬 D01965 💬 Silodosin [2]  6 , 13 💬
19 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00636 💬 Amiodarone [2] 28, 127 💬
20 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D02910 💬 Amiodarone [2] 28, 127 💬
21 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00255 💬 Carvedilol [5]  6 , 57, 86, 113, 210 💬
22 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D03415 💬 Carvedilol [5]  6 , 57, 86, 113, 210 💬
23 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D02349 💬 Dipivefrin [1]  6  💬
24 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00608 💬 Doxazosin [2] 57, 67 💬
25 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D07874 💬 Doxazosin [2] 57, 67 💬
26 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D01277 💬 Droxidopa [5]  5 ,  6 , 17, 169, 170 💬
27 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00124 💬 Ephedrine [1] 11 💬
28 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00095 💬 Epinephrine [3] 46, 70, 96 💬
29 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00996 💬 Epinephrine [3] 46, 70, 96 💬
30 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D02149 💬 Epinephrine [3] 46, 70, 96 💬
31 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D02268 💬 Ergoloid mesylate [2]  6 , 206 💬
32 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08064 💬 Ifenprodil [1] 85 💬
33 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00680 💬 Methylergometrine [3] 118, 280, 288 💬
34 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08207 💬 Methylergometrine [3] 118, 280, 288 💬
35 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D01307 💬 Midodrine [3]  6 , 17, 58 💬
36 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08220 💬 Midodrine [3]  6 , 17, 58 💬
37 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00076 💬 Norepinephrine [1] 22 💬
38 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D05206 💬 Norepinephrine [1] 22 💬
39 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00454 💬 Olanzapine [2]  2 ,  8  💬
40 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D06623 💬 Olanzapine [2]  2 ,  8  💬
41 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00511 💬 Phenylephrine [1] 22 💬
42 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08365 💬 Phenylephrine [1] 22 💬
43 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00485 💬 Pseudoephedrine [1] 17 💬
44 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D05648 💬 Pseudoephedrine [1] 17 💬
45 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D05649 💬 Pseudoephedrine [1] 17 💬
46 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08449 💬 Pseudoephedrine [1] 17 💬
47 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D00610 💬 Terazosin [1]  6  💬
48 Vascular smooth muscle contraction 💬
 [3] ADRA1A, ADRA1B, ADRA1D 💬 D08569 💬 Terazosin [1]  6  💬
49 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00150 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
50 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D02014 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
51 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00522 💬 Candesartan [2] 58, 67 💬
52 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00522 💬 Candesartan cilexetil [1] 67 💬
53 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00626 💬 Candesartan cilexetil [1] 67 💬
54 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
55 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
56 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
57 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00627 💬 Telmisartan [2] 66, 67 💬
58 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
59 Vascular smooth muscle contraction 💬
 [2] AGTR1, EDNRA 💬 D11776 💬 Sparsentan [3] 66, 218, 222 💬
60 Vascular smooth muscle contraction 💬
 [1] AVPR1A 💬 D01236 💬 Conivaptan [1] 86 💬
61 Vascular smooth muscle contraction 💬
 [1] AVPR1A 💬 D07748 💬 Conivaptan [1] 86 💬
62 Vascular smooth muscle contraction 💬
 [2] AVPR1A, AVPR1B 💬 D06672 💬 Terlipressin [1] 299 💬
63 Vascular smooth muscle contraction 💬
 [2] AVPR1A, AVPR1B 💬 D00101 💬 Vasopressin [1] 210 💬
64 Vascular smooth muscle contraction 💬
 [1] BRAF 💬 D10064 💬 Dabrafenib [1] 34 💬
65 Vascular smooth muscle contraction 💬
 [2] BRAF, RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
66 Vascular smooth muscle contraction 💬
 [2] BRAF, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
67 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine [4] 13, 51, 67, 298 💬
68 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine [4] 13, 51, 67, 298 💬
69 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
70 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine [1] 67 💬
71 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem [3] 51, 58, 86 💬
72 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem [3] 51, 58, 86 💬
73 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
74 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine [1]  6  💬
75 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine [2] 70, 86 💬
76 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine [2] 70, 86 💬
77 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine [2] 50, 81 💬
78 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine [1] 90 💬
79 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline [2] 58, 272 💬
80 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline [2] 58, 272 💬
81 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine [1] 226 💬
82 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
83 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil [3] 96, 140, 167 💬
84 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil [3] 96, 140, 167 💬
85 Vascular smooth muscle contraction 💬
 [1] CALCA 💬 D11055 💬 Fremanezumab [2] 124, 226 💬
86 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D07077 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬
87 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
88 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
89 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D10135 💬 Macitentan [5] 51, 85, 86, 88, 210 💬
90 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D07171 💬 Sitaxentan [1] 86 💬
91 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D07741 💬 Zibotentan [1] 51 💬
92 Vascular smooth muscle contraction 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 D00517 💬 Amyl Nitrite [1] 58 💬
93 Vascular smooth muscle contraction 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 D09572 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬
94 Vascular smooth muscle contraction 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
95 Vascular smooth muscle contraction 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
96 Vascular smooth muscle contraction 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
97 Vascular smooth muscle contraction 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
98 Vascular smooth muscle contraction 💬
 [1] NPR1 💬 D05147 💬 Nesiritide [2] 46, 58 💬
99 Vascular smooth muscle contraction 💬
 [2] NPR1, NPR2 💬 D04051 💬 Erythrityl tetranitrate [1] 46 💬
100 Vascular smooth muscle contraction 💬
 [1] NPR2 💬 D11190 💬 Vosoritide [1] 276 💬
101 Vascular smooth muscle contraction 💬
 [4] PRKCD, PRKCE, PRKCH, PRKCQ 💬 D09671 💬 Sotrastaurin [1] 97 💬
102 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 D02720 💬 Beraprost [1] 86 💬
103 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 D00106 💬 Epoprostenol [1] 86 💬
104 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 D01337 💬 Epoprostenol [1] 86 💬
105 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 D01385 💬 Ibudilast [2]  2 , 13 💬
106 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 D02721 💬 Iloprost [4] 51, 84, 85, 86 💬
107 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 D10725 💬 Ralinepag [1] 86 💬
108 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 D09994 💬 Selexipag [6] 47, 51, 70, 84, 86, 88 💬
109 Vascular smooth muscle contraction 💬
 [1] PTGIR 💬 D06213 💬 Treprostinil [6] 51, 84, 85, 86, 88, 210 💬
110 Vascular smooth muscle contraction 💬
 [2] ROCK1, ROCK2 💬 D07941 💬 Fasudil [4]  2 ,  5 ,  7 , 51 💬
111 Vascular smooth muscle contraction 💬
 [1] ROCK2 💬 D11815 💬 Belumosudil [1] 51 💬