Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 NOD-like receptor signaling pathway 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
2 NOD-like receptor signaling pathway 💬
 [1] CASR 💬 D03504 💬 Cinacalcet [2] 85, 238 💬
3 NOD-like receptor signaling pathway 💬
 [1] CASR 💬 D03505 💬 Cinacalcet [2] 85, 238 💬
4 NOD-like receptor signaling pathway 💬
 [4] CCL2, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
5 NOD-like receptor signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab [1] 49 💬
6 NOD-like receptor signaling pathway 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab [1] 49 💬
7 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab [2] 46, 49 💬
8 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬
9 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a [1] 56 💬
10 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b [2] 25, 34 💬
11 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬
12 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b [1] 13 💬
13 NOD-like receptor signaling pathway 💬
 [2] IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a [1] 13 💬
14 NOD-like receptor signaling pathway 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
15 NOD-like receptor signaling pathway 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
16 NOD-like receptor signaling pathway 💬
 [1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
17 NOD-like receptor signaling pathway 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
18 NOD-like receptor signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
19 NOD-like receptor signaling pathway 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
20 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
21 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 D10871 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
22 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 D10944 💬 Itacitinib [5] 46, 51, 60, 97, 228 💬
23 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 D10653 💬 Peficitinib [1] 46 💬
24 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 D09959 💬 Ruxolitinib [1] 228 💬
25 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
26 NOD-like receptor signaling pathway 💬
 [2] JAK1, TYK2 💬 D09970 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
27 NOD-like receptor signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
28 NOD-like receptor signaling pathway 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
29 NOD-like receptor signaling pathway 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
30 NOD-like receptor signaling pathway 💬
 [1] PRKCD 💬 D09671 💬 Sotrastaurin [1] 97 💬
31 NOD-like receptor signaling pathway 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
32 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
33 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
34 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
35 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
36 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
37 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
38 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
39 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
40 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
41 NOD-like receptor signaling pathway 💬
 [1] TYK2 💬 D11817 💬 Deucravacitinib [2] 96, 97 💬