Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Natural killer cell mediated cytotoxicity 💬
 [1] BRAF 💬 D10064 💬 Dabrafenib [1] 34 💬
2 Natural killer cell mediated cytotoxicity 💬
 [2] BRAF, RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
3 Natural killer cell mediated cytotoxicity 💬
 [2] BRAF, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
4 Natural killer cell mediated cytotoxicity 💬
 [1] CSF2 💬 D11343 💬 Otilimab [2] 46, 256 💬
5 Natural killer cell mediated cytotoxicity 💬
 [2] FYN, LCK 💬 D03658 💬 Dasatinib [2] 51, 85 💬
6 Natural killer cell mediated cytotoxicity 💬
 [2] FYN, LCK 💬 D06414 💬 Dasatinib [2] 51, 85 💬
7 Natural killer cell mediated cytotoxicity 💬
 [5] HLA-A, HLA-B, HLA-C, HLA-E, HLA-G 💬 D04318 💬 Glatiramer [4]  2 , 13, 96, 156 💬
8 Natural killer cell mediated cytotoxicity 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab [1] 49 💬
9 Natural killer cell mediated cytotoxicity 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab [1] 49 💬
10 Natural killer cell mediated cytotoxicity 💬
 [2] IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab [2] 46, 49 💬
11 Natural killer cell mediated cytotoxicity 💬
 [2] IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬
12 Natural killer cell mediated cytotoxicity 💬
 [2] IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a [1] 56 💬
13 Natural killer cell mediated cytotoxicity 💬
 [2] IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b [2] 25, 34 💬
14 Natural killer cell mediated cytotoxicity 💬
 [2] IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬
15 Natural killer cell mediated cytotoxicity 💬
 [2] IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b [1] 13 💬
16 Natural killer cell mediated cytotoxicity 💬
 [2] IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a [1] 13 💬
17 Natural killer cell mediated cytotoxicity 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [2] 49, 107 💬
18 Natural killer cell mediated cytotoxicity 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
19 Natural killer cell mediated cytotoxicity 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
20 Natural killer cell mediated cytotoxicity 💬
 [1] ITGAL 💬 D03959 💬 Efalizumab [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
21 Natural killer cell mediated cytotoxicity 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
22 Natural killer cell mediated cytotoxicity 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
23 Natural killer cell mediated cytotoxicity 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
24 Natural killer cell mediated cytotoxicity 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
25 Natural killer cell mediated cytotoxicity 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
26 Natural killer cell mediated cytotoxicity 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
27 Natural killer cell mediated cytotoxicity 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
28 Natural killer cell mediated cytotoxicity 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
29 Natural killer cell mediated cytotoxicity 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
30 Natural killer cell mediated cytotoxicity 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
31 Natural killer cell mediated cytotoxicity 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [1] 222 💬
32 Natural killer cell mediated cytotoxicity 💬
 [1] SYK 💬 D09347 💬 Fostamatinib [4] 46, 49, 61, 66 💬
33 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
34 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
35 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
36 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
37 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
38 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
39 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
40 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
41 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
42 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
43 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬