Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Th1 and Th2 cell differentiation 💬
 [3] CD3D, CD3E, CD3G 💬 D05092 💬 Muromonab [3] 60, 96, 97 💬
2 Th1 and Th2 cell differentiation 💬
 [3] CD3D, CD3E, CD3G 💬 D08959 💬 Otelixizumab [1] 46 💬
3 Th1 and Th2 cell differentiation 💬
 [3] CD3D, CD3E, CD3G 💬 D06314 💬 Visilizumab [2] 96, 97 💬
4 Th1 and Th2 cell differentiation 💬
 [1] CD3E 💬 D11463 💬 Mosunetuzumab [1] 49 💬
5 Th1 and Th2 cell differentiation 💬
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 💬 D04318 💬 Glatiramer [4]  2 , 13, 96, 156 💬
6 Th1 and Th2 cell differentiation 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [2] 49, 107 💬
7 Th1 and Th2 cell differentiation 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
8 Th1 and Th2 cell differentiation 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
9 Th1 and Th2 cell differentiation 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
10 Th1 and Th2 cell differentiation 💬
 [1] IL13 💬 D08857 💬 Anrukinzumab [1] 97 💬
11 Th1 and Th2 cell differentiation 💬
 [1] IL13 💬 D09633 💬 Lebrikizumab [1] 85 💬
12 Th1 and Th2 cell differentiation 💬
 [1] IL13 💬 D09979 💬 Tralokinumab [2] 85, 97 💬
13 Th1 and Th2 cell differentiation 💬
 [1] IL2RA 💬 D03058 💬 Basiliximab [6]  2 , 50, 66, 97, 222, 228 💬
14 Th1 and Th2 cell differentiation 💬
 [1] IL2RA 💬 D03639 💬 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284 💬
15 Th1 and Th2 cell differentiation 💬
 [3] IL2RA, IL2RB, IL2RG 💬 D00748 💬 Aldesleukin [6]  2 , 35, 49, 65, 96, 97 💬
16 Th1 and Th2 cell differentiation 💬
 [1] IL4 💬 D03117 💬 Binetrakin [1] 46 💬
17 Th1 and Th2 cell differentiation 💬
 [1] IL4R 💬 D10354 💬 Dupilumab [4] 51, 98, 160, 162 💬
18 Th1 and Th2 cell differentiation 💬
 [1] IL5 💬 D04923 💬 Mepolizumab [4] 44, 45, 98, 162 💬
19 Th1 and Th2 cell differentiation 💬
 [1] IL5 💬 D08985 💬 Reslizumab [2] 44, 98 💬
20 Th1 and Th2 cell differentiation 💬
 [1] JAK1 💬 D10871 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
21 Th1 and Th2 cell differentiation 💬
 [1] JAK1 💬 D10944 💬 Itacitinib [5] 46, 51, 60, 97, 228 💬
22 Th1 and Th2 cell differentiation 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
23 Th1 and Th2 cell differentiation 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
24 Th1 and Th2 cell differentiation 💬
 [2] JAK1, JAK2 💬 D09959 💬 Ruxolitinib [1] 228 💬
25 Th1 and Th2 cell differentiation 💬
 [3] JAK1, JAK2, JAK3 💬 D10653 💬 Peficitinib [1] 46 💬
26 Th1 and Th2 cell differentiation 💬
 [4] JAK1, JAK2, JAK3, TYK2 💬 D09970 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
27 Th1 and Th2 cell differentiation 💬
 [1] LCK 💬 D03658 💬 Dasatinib [2] 51, 85 💬
28 Th1 and Th2 cell differentiation 💬
 [1] LCK 💬 D06414 💬 Dasatinib [2] 51, 85 💬
29 Th1 and Th2 cell differentiation 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
30 Th1 and Th2 cell differentiation 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
31 Th1 and Th2 cell differentiation 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
32 Th1 and Th2 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
33 Th1 and Th2 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
34 Th1 and Th2 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
35 Th1 and Th2 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
36 Th1 and Th2 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [1] 222 💬
37 Th1 and Th2 cell differentiation 💬
 [1] PRKCQ 💬 D09671 💬 Sotrastaurin [1] 97 💬
38 Th1 and Th2 cell differentiation 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
39 Th1 and Th2 cell differentiation 💬
 [1] TYK2 💬 D11817 💬 Deucravacitinib [2] 96, 97 💬