Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00150 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
2 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D02014 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
3 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00522 💬 Candesartan [2] 58, 67 💬
4 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00522 💬 Candesartan cilexetil [1] 67 💬
5 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00626 💬 Candesartan cilexetil [1] 67 💬
6 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
7 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
8 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
9 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D11776 💬 Sparsentan [3] 66, 218, 222 💬
10 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00627 💬 Telmisartan [2] 66, 67 💬
11 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
12 Aldosterone synthesis and secretion 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00297 💬 Digitoxin [1] 299 💬
13 Aldosterone synthesis and secretion 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00298 💬 Digoxin [3]  8 , 46, 210 💬
14 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine [4] 13, 51, 67, 298 💬
15 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine [4] 13, 51, 67, 298 💬
16 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
17 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine [1] 67 💬
18 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem [3] 51, 58, 86 💬
19 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem [3] 51, 58, 86 💬
20 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
21 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine [1]  6  💬
22 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine [2] 70, 86 💬
23 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine [2] 70, 86 💬
24 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine [2] 50, 81 💬
25 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine [1] 90 💬
26 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline [2] 58, 272 💬
27 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline [2] 58, 272 💬
28 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine [1] 226 💬
29 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
30 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil [3] 96, 140, 167 💬
31 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil [3] 96, 140, 167 💬
32 Aldosterone synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 D01303 💬 Flunarizine [4] 58, 86, 149, 215 💬
33 Aldosterone synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 D07971 💬 Flunarizine [4] 58, 86, 149, 215 💬
34 Aldosterone synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 D00399 💬 Valproic acid [17]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331 💬
35 Aldosterone synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 D00538 💬 Zonisamide [1]  6  💬
36 Aldosterone synthesis and secretion 💬
 [1] CYP11B2 💬 D11061 💬 Osilodrostat [1] 75 💬
37 Aldosterone synthesis and secretion 💬
 [1] KCNJ5 💬 D00636 💬 Amiodarone [2] 28, 127 💬
38 Aldosterone synthesis and secretion 💬
 [1] KCNJ5 💬 D02910 💬 Amiodarone [2] 28, 127 💬
39 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [15]  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
40 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 D00284 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬
41 Aldosterone synthesis and secretion 💬
 [1] NPR1 💬 D04051 💬 Erythrityl tetranitrate [1] 46 💬
42 Aldosterone synthesis and secretion 💬
 [1] NPR1 💬 D05147 💬 Nesiritide [2] 46, 58 💬
43 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D00227 💬 Aminophylline [1] 63 💬
44 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D05429 💬 Aminophylline [1] 63 💬
45 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D07546 💬 Bucladesine [1] 246 💬
46 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D00528 💬 Caffeine [9]  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
47 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D01453 💬 Caffeine [9]  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
48 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D00718 💬 Flavoxate [1] 226 💬
49 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D07961 💬 Flavoxate [1] 226 💬
50 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D00371 💬 Theophylline [2] 236, 299 💬
51 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D01712 💬 Theophylline [2] 236, 299 💬
52 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D02017 💬 Theophylline [2] 236, 299 💬
53 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D06103 💬 Theophylline [2] 236, 299 💬
54 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D06104 💬 Theophylline [2] 236, 299 💬
55 Aldosterone synthesis and secretion 💬
 [1] PRKCE 💬 D09671 💬 Sotrastaurin [1] 97 💬