Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine [4] 13, 51, 67, 298 💬
2 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine [4] 13, 51, 67, 298 💬
3 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
4 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine [1] 67 💬
5 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem [3] 51, 58, 86 💬
6 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem [3] 51, 58, 86 💬
7 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
8 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine [1]  6  💬
9 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine [2] 70, 86 💬
10 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine [2] 70, 86 💬
11 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine [2] 50, 81 💬
12 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine [1] 90 💬
13 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline [2] 58, 272 💬
14 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline [2] 58, 272 💬
15 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine [1] 226 💬
16 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
17 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil [3] 96, 140, 167 💬
18 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil [3] 96, 140, 167 💬
19 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D11486 💬 Lonapegsomatropin [1] 78 💬
20 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
21 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
22 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D05394 💬 Pegvisomant [1] 78 💬
23 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D11194 💬 Somapacitan [1] 78 💬
24 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D02691 💬 Somatotropin [23]  2 ,  3 , 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299 💬
25 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D11193 💬 Somavaratan [1] 78 💬
26 Growth hormone synthesis, secretion and action 💬
 [1] GHRHR 💬 D08523 💬 Somatorelin [2] 13, 78 💬
27 Growth hormone synthesis, secretion and action 💬
 [1] GHRHR 💬 D06655 💬 Tesamorelin [2] 78, 265 💬
28 Growth hormone synthesis, secretion and action 💬
 [1] GHSR 💬 D10563 💬 Macimorelin [1] 78 💬
29 Growth hormone synthesis, secretion and action 💬
 [1] JAK2 💬 D10308 💬 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
30 Growth hormone synthesis, secretion and action 💬
 [1] JAK2 💬 D10653 💬 Peficitinib [1] 46 💬
31 Growth hormone synthesis, secretion and action 💬
 [1] JAK2 💬 D09959 💬 Ruxolitinib [1] 228 💬
32 Growth hormone synthesis, secretion and action 💬
 [1] JAK2 💬 D09970 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
33 Growth hormone synthesis, secretion and action 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
34 Growth hormone synthesis, secretion and action 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
35 Growth hormone synthesis, secretion and action 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
36 Growth hormone synthesis, secretion and action 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
37 Growth hormone synthesis, secretion and action 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
38 Growth hormone synthesis, secretion and action 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
39 Growth hormone synthesis, secretion and action 💬
 [1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
40 Growth hormone synthesis, secretion and action 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [41]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
41 Growth hormone synthesis, secretion and action 💬
 [1] MTOR 💬 D06068 💬 Temsirolimus [4] 13, 34, 89, 331 💬
42 Growth hormone synthesis, secretion and action 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
43 Growth hormone synthesis, secretion and action 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
44 Growth hormone synthesis, secretion and action 💬
 [1] RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
45 Growth hormone synthesis, secretion and action 💬
 [1] RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
46 Growth hormone synthesis, secretion and action 💬
 [4] SSTR1, SSTR2, SSTR3, SSTR5 💬 D10147 💬 Pasireotide [3] 67, 74, 75 💬
47 Growth hormone synthesis, secretion and action 💬
 [4] SSTR1, SSTR2, SSTR3, SSTR5 💬 D07431 💬 Somatostatin [2] 67, 78 💬
48 Growth hormone synthesis, secretion and action 💬
 [1] SSTR2 💬 D00442 💬 Octreotide [7] 67, 75, 84, 85, 89, 193, 227 💬
49 Growth hormone synthesis, secretion and action 💬
 [1] SSTR2 💬 D06495 💬 Octreotide [7] 67, 75, 84, 85, 89, 193, 227 💬