Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Leishmaniasis 💬
 [1] C3 💬 D11613 💬 Pegcetacoplan [3]  2 , 62, 222 💬
2 Leishmaniasis 💬
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 💬 D04318 💬 Glatiramer [4]  2 , 13, 96, 156 💬
3 Leishmaniasis 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [2] 49, 107 💬
4 Leishmaniasis 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
5 Leishmaniasis 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
6 Leishmaniasis 💬
 [4] IL10, IL1A, IL1B, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
7 Leishmaniasis 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
8 Leishmaniasis 💬
 [1] IL1A 💬 D11253 💬 Bermekimab [1] 51 💬
9 Leishmaniasis 💬
 [2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
10 Leishmaniasis 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
11 Leishmaniasis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
12 Leishmaniasis 💬
 [1] IL4 💬 D03117 💬 Binetrakin [1] 46 💬
13 Leishmaniasis 💬
 [1] ITGA4 💬 D10540 💬 Abrilumab [2] 96, 97 💬
14 Leishmaniasis 💬
 [1] ITGA4 💬 D06590 💬 Firategrast [1] 13 💬
15 Leishmaniasis 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
16 Leishmaniasis 💬
 [1] ITGA4 💬 D08083 💬 Vedolizumab [3] 94, 96, 97 💬
17 Leishmaniasis 💬
 [1] JAK1 💬 D10871 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
18 Leishmaniasis 💬
 [1] JAK1 💬 D10944 💬 Itacitinib [5] 46, 51, 60, 97, 228 💬
19 Leishmaniasis 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
20 Leishmaniasis 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
21 Leishmaniasis 💬
 [2] JAK1, JAK2 💬 D10653 💬 Peficitinib [1] 46 💬
22 Leishmaniasis 💬
 [2] JAK1, JAK2 💬 D09959 💬 Ruxolitinib [1] 228 💬
23 Leishmaniasis 💬
 [2] JAK1, JAK2 💬 D09970 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
24 Leishmaniasis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
25 Leishmaniasis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
26 Leishmaniasis 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
27 Leishmaniasis 💬
 [1] PTGS2 💬 D01545 💬 Aceclofenac [1] 46 💬
28 Leishmaniasis 💬
 [1] PTGS2 💬 D00217 💬 Acetaminophen [18]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337 💬
29 Leishmaniasis 💬
 [1] PTGS2 💬 D00109 💬 Acetylsalicylic acid [15] 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
30 Leishmaniasis 💬
 [1] PTGS2 💬 D00567 💬 Celecoxib [10]  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
31 Leishmaniasis 💬
 [1] PTGS2 💬 D00903 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
32 Leishmaniasis 💬
 [1] PTGS2 💬 D00904 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
33 Leishmaniasis 💬
 [1] PTGS2 💬 D07816 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
34 Leishmaniasis 💬
 [1] PTGS2 💬 D00130 💬 Diflunisal [1] 28 💬
35 Leishmaniasis 💬
 [1] PTGS2 💬 D00315 💬 Etodolac [1] 46 💬
36 Leishmaniasis 💬
 [1] PTGS2 💬 D03710 💬 Etoricoxib [2] 46, 271 💬
37 Leishmaniasis 💬
 [1] PTGS2 💬 D00330 💬 Flurbiprofen [3] 13, 21, 46 💬
38 Leishmaniasis 💬
 [1] PTGS2 💬 D01475 💬 Flurbiprofen [3] 13, 21, 46 💬
39 Leishmaniasis 💬
 [1] PTGS2 💬 D02290 💬 Flurbiprofen [3] 13, 21, 46 💬
40 Leishmaniasis 💬
 [1] PTGS2 💬 D00126 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬
41 Leishmaniasis 💬
 [1] PTGS2 💬 D01122 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬
42 Leishmaniasis 💬
 [1] PTGS2 💬 D04490 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬
43 Leishmaniasis 💬
 [1] PTGS2 💬 D06606 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬
44 Leishmaniasis 💬
 [1] PTGS2 💬 D00141 💬 Indomethacin [3] 225, 271, 298 💬
45 Leishmaniasis 💬
 [1] PTGS2 💬 D01565 💬 Indomethacin [3] 225, 271, 298 💬
46 Leishmaniasis 💬
 [1] PTGS2 💬 D02110 💬 Indomethacin [3] 225, 271, 298 💬
47 Leishmaniasis 💬
 [1] PTGS2 💬 D00132 💬 Ketoprofen [1] 46 💬
48 Leishmaniasis 💬
 [1] PTGS2 💬 D00813 💬 Ketorolac [2] 70, 226 💬
49 Leishmaniasis 💬
 [1] PTGS2 💬 D08104 💬 Ketorolac [2] 70, 226 💬
50 Leishmaniasis 💬
 [1] PTGS2 💬 D08149 💬 Loxoprofen [2] 46, 271 💬
51 Leishmaniasis 💬
 [1] PTGS2 💬 D03714 💬 Lumiracoxib [1] 46 💬
52 Leishmaniasis 💬
 [1] PTGS2 💬 D00969 💬 Meloxicam [4] 46, 49, 271, 296 💬
53 Leishmaniasis 💬
 [1] PTGS2 💬 D00118 💬 Naproxen [4] 13, 46, 107, 271 💬
54 Leishmaniasis 💬
 [1] PTGS2 💬 D01049 💬 Nimesulide [1] 46 💬
55 Leishmaniasis 💬
 [1] PTGS2 💬 D03716 💬 Parecoxib [2] 46, 271 💬
56 Leishmaniasis 💬
 [1] PTGS2 💬 D00568 💬 Rofecoxib [1] 46 💬
57 Leishmaniasis 💬
 [1] PTGS2 💬 D00428 💬 Salsalate [1]  5  💬
58 Leishmaniasis 💬
 [1] PTGS2 💬 D00120 💬 Sulindac [1] 206 💬
59 Leishmaniasis 💬
 [1] PTGS2 💬 D01183 💬 Tolfenamic acid [1]  5  💬
60 Leishmaniasis 💬
 [1] PTGS2 💬 D02709 💬 Valdecoxib [1] 46 💬
61 Leishmaniasis 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
62 Leishmaniasis 💬
 [3] TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab [4] 51, 85, 222, 274 💬
63 Leishmaniasis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
64 Leishmaniasis 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
65 Leishmaniasis 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
66 Leishmaniasis 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
67 Leishmaniasis 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
68 Leishmaniasis 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
69 Leishmaniasis 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
70 Leishmaniasis 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
71 Leishmaniasis 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
72 Leishmaniasis 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬