Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Chagas disease 💬
 [1] ACE 💬 D00620 💬 Benazepril [4] 49, 57, 218, 224 💬
2 Chagas disease 💬
 [1] ACE 💬 D07499 💬 Benazepril [4] 49, 57, 218, 224 💬
3 Chagas disease 💬
 [1] ACE 💬 D00251 💬 Captopril [8]  6 , 17, 46, 86, 96, 97, 107, 271 💬
4 Chagas disease 💬
 [1] ACE 💬 D01069 💬 Cilazapril [1] 66 💬
5 Chagas disease 💬
 [1] ACE 💬 D07699 💬 Cilazapril [1] 66 💬
6 Chagas disease 💬
 [1] ACE 💬 D00621 💬 Enalapril [6] 19, 46, 66, 113, 210, 222 💬
7 Chagas disease 💬
 [1] ACE 💬 D07892 💬 Enalapril [6] 19, 46, 66, 113, 210, 222 💬
8 Chagas disease 💬
 [1] ACE 💬 D08068 💬 Imidapril [1] 67 💬
9 Chagas disease 💬
 [1] ACE 💬 D00362 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬
10 Chagas disease 💬
 [1] ACE 💬 D08131 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬
11 Chagas disease 💬
 [1] ACE 💬 D00623 💬 Moexipril [1] 93 💬
12 Chagas disease 💬
 [1] ACE 💬 D08225 💬 Moexipril [1] 93 💬
13 Chagas disease 💬
 [1] ACE 💬 D00624 💬 Perindopril [4] 58, 113, 167, 222 💬
14 Chagas disease 💬
 [1] ACE 💬 D03753 💬 Perindopril [4] 58, 113, 167, 222 💬
15 Chagas disease 💬
 [1] ACE 💬 D00459 💬 Quinapril [1] 19 💬
16 Chagas disease 💬
 [1] ACE 💬 D03752 💬 Quinapril [1] 19 💬
17 Chagas disease 💬
 [1] ACE 💬 D00421 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬
18 Chagas disease 💬
 [1] C3 💬 D11613 💬 Pegcetacoplan [3]  2 , 62, 222 💬
19 Chagas disease 💬
 [5] CCL2, IL10, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
20 Chagas disease 💬
 [3] CD3D, CD3E, CD3G 💬 D05092 💬 Muromonab [3] 60, 96, 97 💬
21 Chagas disease 💬
 [3] CD3D, CD3E, CD3G 💬 D08959 💬 Otelixizumab [1] 46 💬
22 Chagas disease 💬
 [3] CD3D, CD3E, CD3G 💬 D06314 💬 Visilizumab [2] 96, 97 💬
23 Chagas disease 💬
 [1] CD3E 💬 D11463 💬 Mosunetuzumab [1] 49 💬
24 Chagas disease 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [2] 49, 107 💬
25 Chagas disease 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
26 Chagas disease 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
27 Chagas disease 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
28 Chagas disease 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
29 Chagas disease 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
30 Chagas disease 💬
 [1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
31 Chagas disease 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
32 Chagas disease 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
33 Chagas disease 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
34 Chagas disease 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
35 Chagas disease 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
36 Chagas disease 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
37 Chagas disease 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
38 Chagas disease 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
39 Chagas disease 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
40 Chagas disease 💬
 [3] TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab [4] 51, 85, 222, 274 💬
41 Chagas disease 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
42 Chagas disease 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
43 Chagas disease 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
44 Chagas disease 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
45 Chagas disease 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
46 Chagas disease 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
47 Chagas disease 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
48 Chagas disease 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
49 Chagas disease 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬