Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D00620 💬 Benazepril [4] 49, 57, 218, 224 💬
2 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D07499 💬 Benazepril [4] 49, 57, 218, 224 💬
3 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D00251 💬 Captopril [8]  6 , 17, 46, 86, 96, 97, 107, 271 💬
4 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D01069 💬 Cilazapril [1] 66 💬
5 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D07699 💬 Cilazapril [1] 66 💬
6 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D00621 💬 Enalapril [6] 19, 46, 66, 113, 210, 222 💬
7 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D07892 💬 Enalapril [6] 19, 46, 66, 113, 210, 222 💬
8 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D08068 💬 Imidapril [1] 67 💬
9 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D00362 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬
10 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D08131 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬
11 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D00623 💬 Moexipril [1] 93 💬
12 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D08225 💬 Moexipril [1] 93 💬
13 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D00624 💬 Perindopril [4] 58, 113, 167, 222 💬
14 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D03753 💬 Perindopril [4] 58, 113, 167, 222 💬
15 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D00459 💬 Quinapril [1] 19 💬
16 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D03752 💬 Quinapril [1] 19 💬
17 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 D00421 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬
18 Coronavirus disease - COVID-19 💬
 [1] ADAM17 💬 D08859 💬 Apratastat [1] 46 💬
19 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00150 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
20 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D02014 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
21 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00522 💬 Candesartan [2] 58, 67 💬
22 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00522 💬 Candesartan cilexetil [1] 67 💬
23 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00626 💬 Candesartan cilexetil [1] 67 💬
24 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
25 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00357 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
26 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D08146 💬 Losartan [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
27 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D11776 💬 Sparsentan [3] 66, 218, 222 💬
28 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00627 💬 Telmisartan [2] 66, 67 💬
29 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
30 Coronavirus disease - COVID-19 💬
 [2] C1R, C1S 💬 D10845 💬 Conestat alfa [1] 61 💬
31 Coronavirus disease - COVID-19 💬
 [1] C1S 💬 D11530 💬 Sutimlimab [1] 61 💬
32 Coronavirus disease - COVID-19 💬
 [1] C3 💬 D11613 💬 Pegcetacoplan [3]  2 , 62, 222 💬
33 Coronavirus disease - COVID-19 💬
 [1] C5 💬 D11696 💬 Crovalimab [2] 62, 109 💬
34 Coronavirus disease - COVID-19 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
35 Coronavirus disease - COVID-19 💬
 [1] C5 💬 D11473 💬 Nomacopan [3] 62, 109, 162 💬
36 Coronavirus disease - COVID-19 💬
 [1] C5 💬 D11477 💬 Pozelimab [2] 11, 62 💬
37 Coronavirus disease - COVID-19 💬
 [1] C5 💬 D11054 💬 Ravulizumab [7]  2 , 11, 13, 50, 62, 66, 109 💬
38 Coronavirus disease - COVID-19 💬
 [1] C5 💬 D11838 💬 Vilobelimab [3] 43, 44, 269 💬
39 Coronavirus disease - COVID-19 💬
 [1] C5AR1 💬 D11093 💬 Avacopan [3] 43, 44, 222 💬
40 Coronavirus disease - COVID-19 💬
 [4] CCL2, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
41 Coronavirus disease - COVID-19 💬
 [1] CFB 💬 D12251 💬 Iptacopan [5] 61, 62, 66, 109, 222 💬
42 Coronavirus disease - COVID-19 💬
 [1] CFD 💬 D11641 💬 Danicopan [2] 62, 222 💬
43 Coronavirus disease - COVID-19 💬
 [1] CSF2 💬 D11343 💬 Otilimab [2] 46, 256 💬
44 Coronavirus disease - COVID-19 💬
 [1] EGFR 💬 D03455 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
45 Coronavirus disease - COVID-19 💬
 [1] EGFR 💬 D04023 💬 Erlotinib [1] 94 💬
46 Coronavirus disease - COVID-19 💬
 [1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
47 Coronavirus disease - COVID-19 💬
 [1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
48 Coronavirus disease - COVID-19 💬
 [1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
49 Coronavirus disease - COVID-19 💬
 [1] EGFR 💬 D04024 💬 Lapatinib [3] 34, 74, 75 💬
50 Coronavirus disease - COVID-19 💬
 [1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
51 Coronavirus disease - COVID-19 💬
 [1] EGFR 💬 D11772 💬 Tesevatinib [1] 67 💬
52 Coronavirus disease - COVID-19 💬
 [1] F2 💬 D09707 💬 Dabigatran [4] 51, 85, 91, 124 💬
53 Coronavirus disease - COVID-19 💬
 [1] F2 💬 D07144 💬 Dabigatran etexilate [1] 51 💬
54 Coronavirus disease - COVID-19 💬
 [1] F2 💬 D06410 💬 Thrombomodulin Alfa [1] 85 💬
55 Coronavirus disease - COVID-19 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab [1] 49 💬
56 Coronavirus disease - COVID-19 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab [1] 49 💬
57 Coronavirus disease - COVID-19 💬
 [2] IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab [2] 46, 49 💬
58 Coronavirus disease - COVID-19 💬
 [2] IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬
59 Coronavirus disease - COVID-19 💬
 [2] IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a [1] 56 💬
60 Coronavirus disease - COVID-19 💬
 [2] IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b [2] 25, 34 💬
61 Coronavirus disease - COVID-19 💬
 [2] IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬
62 Coronavirus disease - COVID-19 💬
 [2] IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b [1] 13 💬
63 Coronavirus disease - COVID-19 💬
 [2] IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a [1] 13 💬
64 Coronavirus disease - COVID-19 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
65 Coronavirus disease - COVID-19 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
66 Coronavirus disease - COVID-19 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
67 Coronavirus disease - COVID-19 💬
 [1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
68 Coronavirus disease - COVID-19 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
69 Coronavirus disease - COVID-19 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
70 Coronavirus disease - COVID-19 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
71 Coronavirus disease - COVID-19 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
72 Coronavirus disease - COVID-19 💬
 [1] IL6R 💬 D11079 💬 Satralizumab [2] 11, 13 💬
73 Coronavirus disease - COVID-19 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [21]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
74 Coronavirus disease - COVID-19 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
75 Coronavirus disease - COVID-19 💬
 [1] JAK1 💬 D10871 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬
76 Coronavirus disease - COVID-19 💬
 [1] JAK1 💬 D10944 💬 Itacitinib [5] 46, 51, 60, 97, 228 💬
77 Coronavirus disease - COVID-19 💬
 [1] JAK1 💬 D10653 💬 Peficitinib [1] 46 💬
78 Coronavirus disease - COVID-19 💬
 [1] JAK1 💬 D09959 💬 Ruxolitinib [1] 228 💬
79 Coronavirus disease - COVID-19 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬
80 Coronavirus disease - COVID-19 💬
 [2] JAK1, TYK2 💬 D09970 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
81 Coronavirus disease - COVID-19 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
82 Coronavirus disease - COVID-19 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
83 Coronavirus disease - COVID-19 💬
 [1] MASP2 💬 D11531 💬 Narsoplimab [4] 64, 66, 109, 222 💬
84 Coronavirus disease - COVID-19 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
85 Coronavirus disease - COVID-19 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
86 Coronavirus disease - COVID-19 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
87 Coronavirus disease - COVID-19 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
88 Coronavirus disease - COVID-19 💬
 [1] SYK 💬 D09347 💬 Fostamatinib [4] 46, 49, 61, 66 💬
89 Coronavirus disease - COVID-19 💬
 [1] TLR7 💬 D02500 💬 Imiquimod [2] 34, 51 💬
90 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
91 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
92 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
93 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
94 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
95 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
96 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
97 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
98 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
99 Coronavirus disease - COVID-19 💬
 [1] TYK2 💬 D11817 💬 Deucravacitinib [2] 96, 97 💬
100 Coronavirus disease - COVID-19 💬
 [1] VWF 💬 D11160 💬 Caplacizumab [1] 64 💬