Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Allograft rejection 💬
 [1] CD40 💬 D11357 💬 Bleselumab [1] 222 💬
2 Allograft rejection 💬
 [1] CD40 💬 D11610 💬 Iscalimab [2] 49, 53 💬
3 Allograft rejection 💬
 [1] CD40 💬 D11597 💬 Ravagalimab [2] 53, 97 💬
4 Allograft rejection 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
5 Allograft rejection 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
6 Allograft rejection 💬
 [2] CD80, CD86 💬 D03222 💬 Belatacept [1] 46 💬
7 Allograft rejection 💬
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G 💬 D04318 💬 Glatiramer [4]  2 , 13, 96, 156 💬
8 Allograft rejection 💬
 [1] IFNG 💬 D11120 💬 Emapalumab [2] 49, 107 💬
9 Allograft rejection 💬
 [1] IFNG 💬 D04242 💬 Fontolizumab [1] 46 💬
10 Allograft rejection 💬
 [2] IL10, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
11 Allograft rejection 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
12 Allograft rejection 💬
 [1] IL4 💬 D03117 💬 Binetrakin [1] 46 💬
13 Allograft rejection 💬
 [1] IL5 💬 D04923 💬 Mepolizumab [4] 44, 45, 98, 162 💬
14 Allograft rejection 💬
 [1] IL5 💬 D08985 💬 Reslizumab [2] 44, 98 💬
15 Allograft rejection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
16 Allograft rejection 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
17 Allograft rejection 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
18 Allograft rejection 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
19 Allograft rejection 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
20 Allograft rejection 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
21 Allograft rejection 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
22 Allograft rejection 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
23 Allograft rejection 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
24 Allograft rejection 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬