Target Gene/Pathway Pathway / Gene

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Graft-versus-host disease 💬	[2] CD80, CD86 💬	D03203 💬	Abatacept	[26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271 ...
2	Graft-versus-host disease 💬	[2] CD80, CD86 💬	D03222 💬	Belatacept	[1] 46 💬
3	Graft-versus-host disease 💬	[20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2 ...	D04318 💬	Glatiramer	[4] 2 , 13, 96, 156 💬
4	Graft-versus-host disease 💬	[1] IFNG 💬	D11120 💬	Emapalumab	[2] 49, 107 💬
5	Graft-versus-host disease 💬	[1] IFNG 💬	D04242 💬	Fontolizumab	[1] 46 💬
6	Graft-versus-host disease 💬	[1] IL1A 💬	D11253 💬	Bermekimab	[1] 51 💬
7	Graft-versus-host disease 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
8	Graft-versus-host disease 💬	[4] IL1A, IL1B, IL6, TNF 💬	D01583 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
9	Graft-versus-host disease 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
10	Graft-versus-host disease 💬	[1] IL1B 💬	D09911 💬	Gevokizumab	[4] 41, 50, 56, 269 💬

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