Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D00620 💬 Benazepril [4] 49, 57, 218, 224 💬
2 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D07499 💬 Benazepril [4] 49, 57, 218, 224 💬
3 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D00251 💬 Captopril [8]  6 , 17, 46, 86, 96, 97, 107, 271 💬
4 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D01069 💬 Cilazapril [1] 66 💬
5 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D07699 💬 Cilazapril [1] 66 💬
6 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D00621 💬 Enalapril [6] 19, 46, 66, 113, 210, 222 💬
7 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D07892 💬 Enalapril [6] 19, 46, 66, 113, 210, 222 💬
8 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D08068 💬 Imidapril [1] 67 💬
9 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D00362 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬
10 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D08131 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬
11 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D00623 💬 Moexipril [1] 93 💬
12 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D08225 💬 Moexipril [1] 93 💬
13 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D00624 💬 Perindopril [4] 58, 113, 167, 222 💬
14 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D03753 💬 Perindopril [4] 58, 113, 167, 222 💬
15 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D00459 💬 Quinapril [1] 19 💬
16 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D03752 💬 Quinapril [1] 19 💬
17 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 D00421 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬
18 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine [4] 13, 51, 67, 298 💬
19 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine [4] 13, 51, 67, 298 💬
20 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
21 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine [1] 67 💬
22 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem [3] 51, 58, 86 💬
23 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem [3] 51, 58, 86 💬
24 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
25 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine [1]  6  💬
26 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine [2] 70, 86 💬
27 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine [2] 70, 86 💬
28 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine [2] 50, 81 💬
29 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine [1] 90 💬
30 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline [2] 58, 272 💬
31 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline [2] 58, 272 💬
32 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine [1] 226 💬
33 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
34 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil [3] 96, 140, 167 💬
35 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil [3] 96, 140, 167 💬
36 Hypertrophic cardiomyopathy 💬
 [2] CACNA2D1, CACNA2D2 💬 D11203 💬 Mirogabalin [1] 70 💬
37 Hypertrophic cardiomyopathy 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 D00332 💬 Gabapentin [5]  6 , 13, 19, 70, 298 💬
38 Hypertrophic cardiomyopathy 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 D02716 💬 Pregabalin [5] 13, 36, 46, 70, 298 💬
39 Hypertrophic cardiomyopathy 💬
 [1] DMD 💬 D11988 💬 Casimersen [1] 113 💬
40 Hypertrophic cardiomyopathy 💬
 [1] DMD 💬 D10114 💬 Drisapersen [1] 113 💬
41 Hypertrophic cardiomyopathy 💬
 [1] DMD 💬 D09900 💬 Eteplirsen [1] 113 💬
42 Hypertrophic cardiomyopathy 💬
 [1] DMD 💬 D11707 💬 Golodirsen [1] 113 💬
43 Hypertrophic cardiomyopathy 💬
 [1] DMD 💬 D11528 💬 Viltolarsen [1] 113 💬
44 Hypertrophic cardiomyopathy 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
45 Hypertrophic cardiomyopathy 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
46 Hypertrophic cardiomyopathy 💬
 [2] IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
47 Hypertrophic cardiomyopathy 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
48 Hypertrophic cardiomyopathy 💬
 [1] ITGA4 💬 D06590 💬 Firategrast [1] 13 💬
49 Hypertrophic cardiomyopathy 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
50 Hypertrophic cardiomyopathy 💬
 [2] ITGA4, ITGB7 💬 D10540 💬 Abrilumab [2] 96, 97 💬
51 Hypertrophic cardiomyopathy 💬
 [2] ITGA4, ITGB7 💬 D08083 💬 Vedolizumab [3] 94, 96, 97 💬
52 Hypertrophic cardiomyopathy 💬
 [1] ITGB7 💬 D09901 💬 Etrolizumab [2] 96, 97 💬
53 Hypertrophic cardiomyopathy 💬
 [1] MYH7 💬 D12265 💬 Mavacamten [1] 58 💬
54 Hypertrophic cardiomyopathy 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [24]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
55 Hypertrophic cardiomyopathy 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [24]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
56 Hypertrophic cardiomyopathy 💬
 [3] TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab [4] 51, 85, 222, 274 💬
57 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
58 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
59 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
60 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
61 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
62 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
63 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
64 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
65 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬